protein

JAK3PROTEIN

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about JAK3PROTEIN: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

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Summary

Janus Kinase 3 is a Janus kinase family member. The protein contains the characteristic domain structure including domain descriptions. The molecular weight is approximately 125 kDa, and the protein localizes to Cytoplasm.

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🔬 Protein Info

Gene Symbol	JAK3PROTEIN
Chromosome	19p13.11
Protein Family	Janus kinase family
Protein Type	Kinase
Function	is a Janus kinase family member.
Primary Expression	lymphoid cells and is essential for signaling by γc-family cytokines (IL-2, IL-4, IL-7, IL-9, IL-15, IL-21)
Subcellular Localization	Cytoplasm
Molecular Weight	125 kDa
UniProt ID	P52333
GeneCards	JAK3PROTEIN
Human Protein Atlas	JAK3PROTEIN
Protein Name	Janus Kinase 3
Gene	JAK3
PDB IDs	1JAK, 3LXK, 5WPX
Associated Diseases	Inflammation, Ms, Neuroinflammation
Interactions	IRF1, GBM, STAT3, TYK2, JAK, PIK3C3
KG Connections	79 knowledge graph edges
Databases	GeneCards NCBI Gene HPA STRING

Wiki Pages (1)

Knowledge base pages for this entity

Canonical Page

Janus Kinase 3

protein · 625 words

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Pathway Diagram

graph TD
    JAK3PROTEIN["JAK3PROTEIN"]
    neurodegeneration["neurodegeneration"]
    JAK3PROTEIN -->|"implicated_in"| neurodegeneration
    style JAK3PROTEIN fill:#4a1a6b,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0

Outgoing (0)

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Incoming (0)

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Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found