gene

IRF1

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about IRF1: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

265Connections

0Hypotheses

0Analyses

50Outgoing

50Incoming

Summary

Page for IRF1 Gene - Interferon Regulatory Factor 1

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🧬 Gene Info

Gene Symbol	IRF1
Full Name	Interferon Regulatory Factor 1
Aliases	Page for IRF1 Gene, Page for IRF1 Protein
Chromosome	5q31.1
Protein Type	Transcription Factor
Function	is a transcription factor encoded by the IRF1 gene located on chromosome 5q31.
Molecular Weight	36 kDa
Amino Acids	325 aa
Pathways	Autophagy, Cell Cycle, Complement, Immune Response, Immunotherapy
UniProt ID	P04855
NCBI Gene ID	3659
Ensembl ID	ENSG00000125347
OMIM	147575
GeneCards	IRF1
Human Protein Atlas	IRF1
Associated Diseases	ALS, Inflammation, Ms, Neuroinflammation
Interactions	CIITA, ATG5, CD8, NPM1, CALCOCO2, NDP52
KG Connections	265 knowledge graph edges
Databases	GeneCards HPA STRING

🔮 Predicted Structure: IRF1 — AlphaFold P04855 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (21)

Knowledge base pages for this entity

Canonical Page

Pathway Diagram

graph TD
    IRF1["IRF1"]
    IRF1 -->|"activates"| Cancer["Cancer"]
    IRF1 -->|"activates"| Ms["Ms"]
    IRF1 -->|"activates"| Tumor["Tumor"]
    IRF1 -->|"inhibits"| Als["Als"]
    IRF1 -->|"regulates"| Leukemia["Leukemia"]
    IRF1 -->|"regulates"| Lymphoma["Lymphoma"]
    NPM1["NPM1"] -->|"activates"| IRF1
    NLRC5["NLRC5"] -->|"activates"| IRF1
    CD8["CD8"] -->|"activates"| IRF1
    NDP52["NDP52"] -->|"inhibits"| IRF1
    CALCOCO2["CALCOCO2"] -->|"inhibits"| IRF1
    ATG5["ATG5"] -->|"inhibits"| IRF1
    ATG3["ATG3"] -->|"regulates"| IRF1
    CIITA["CIITA"] -->|"activates"| IRF1
    NFKB["NFKB"] -->|"inhibits"| IRF1
    UBIQUITIN["UBIQUITIN"] -->|"inhibits"| IRF1

Outgoing (136)

Target	Relation	Type	Str
ZBP1	regulates	protein	0.90
BST2	upregulates	protein	0.90
Cancer	activates	disease	0.85
Inflammation	activates	disease	0.85
NLRC5	binds	gene	0.80
CIITA	binds	gene	0.80
Type I Interferon-Like Gene Signature	mediates	phenotype	0.80
Tumor	activates	disease	0.75
Lymphoma	activates	disease	0.75
Alzheimer	regulates	disease	0.75
Autophagy	activates	pathway	0.70
Immune Response	regulates	pathway	0.70
Ms	activates	disease	0.65
Als	inhibits	disease	0.65
Leukemia	regulates	disease	0.65
Als	regulates	disease	0.65
Tumor	regulates	disease	0.65
Lymphoma	regulates	disease	0.65
Ms	regulates	disease	0.65
Als	associated_with	disease	0.65
Ms	associated_with	disease	0.65
Neuroinflammation	associated_with	disease	0.65
Inflammation	associated_with	disease	0.65
Als	expressed_in	disease	0.65
Aging	activates	disease	0.65
Als	biomarker_for	disease	0.65
Ms	biomarker_for	disease	0.65
Ischemia	biomarker_for	disease	0.65
Inflammation	regulates	disease	0.65
Neurodegeneration	regulates	disease	0.65
Ms	interacts_with	disease	0.65
Neuroinflammation	regulates	disease	0.65
ALS	inhibits	disease	0.65
Autoimmune	activates	disease	0.65
Infection	activates	disease	0.65
Als	activates	disease	0.65
BST2	activates	protein	0.64
CIITA	activates	gene	0.60
ATG5	inhibits	gene	0.60
CD8	activates	gene	0.60
NPM1	activates	gene	0.60
CALCOCO2	inhibits	gene	0.60
NDP52	inhibits	gene	0.60
TNF	activates	gene	0.60
STAT1	activates	gene	0.60
RB1CC1	regulates	gene	0.60
TNFR1	activates	gene	0.60
CD19	regulates	gene	0.60
BECN1	regulates	gene	0.60
NLRC5	activates	gene	0.60

Incoming (129)

Source	Relation	Type	Str
NPM1	associated_with	protein	0.90
TNF-α	upstream_of	protein	0.90
NPM1	interacts_with	protein	0.85
INFLAMMATION	activates	gene	0.80
CD8	activates	gene	0.70
STAT3	activates	gene	0.70
CANCER	activates	gene	0.70
AUTOPHAGY	activates	gene	0.70
ALZHEIMER'S DISEASE	regulates	gene	0.70
GENES	regulates	gene	0.70
NPM1	activates	gene	0.60
NLRC5	activates	gene	0.60
NDP52	inhibits	gene	0.60
CALCOCO2	inhibits	gene	0.60
ATG5	inhibits	gene	0.60
ATG3	regulates	gene	0.60
CIITA	activates	gene	0.60
MAP1LC3B	associated_with	gene	0.60
UBIQUITIN	inhibits	gene	0.60
PIK3C3	inhibits	gene	0.60
STAT3	inhibits	gene	0.60
JAK3	inhibits	gene	0.60
CD19	regulates	gene	0.60
TNF	activates	gene	0.60
BECN1	regulates	gene	0.60
RB1CC1	regulates	gene	0.60
STAT1	activates	gene	0.60
TNFR1	activates	gene	0.60
HSPA1B	associated_with	gene	0.60
SERPINE1	associated_with	gene	0.60
HSPA1A	associated_with	gene	0.60
TNFAIP3	associated_with	gene	0.60
CEBPB	associated_with	gene	0.60
CD4	regulates	gene	0.60
REL	associated_with	gene	0.60
CD8	regulates	gene	0.60
STAT3	associated_with	gene	0.60
MFN1	activates	gene	0.60
PARKIN	activates	gene	0.60
ISG15	activates	gene	0.60
BIN1	regulates	gene	0.60
LOX	regulates	gene	0.60
IL1B	interacts_with	gene	0.60
SOD2	interacts_with	gene	0.60
MARCKS	associated_with	gene	0.60
LAMP1	interacts_with	gene	0.60
MBP	interacts_with	gene	0.60
LAMP2	interacts_with	gene	0.60
S100A9	associated_with	gene	0.60
EP300	regulates	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

IRF1

Understanding Entity Pages

Summary

Wiki Pages (21)

IRF1 Gene - Interferon Regulatory Factor 1

NPM1 Gene

nlrc5-protein

S100 Protein Signaling Pathway in Neurodegeneration

Tuberomammillary Nucleus in Sleep-Wake

MYH2 Gene

PSMB9 Protein

PSMB8

HMGB1 — High Mobility Group Box 1

ADCY9 Gene

LITAF — Lipopolysaccharide-Induced Tumor Necrosis Factor Factor

STAT1 Protein

STAT2 Protein

Class II Major Histocompatibility Complex Transactivator

CALM2 Gene

IRF1 Protein - Interferon Regulatory Factor 1

PPP5C Protein

Calmodulin 2 (CALM2)

IFNG Gene