gene

KANSL1

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about KANSL1: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

21Connections
0Hypotheses
0Analyses
12Outgoing
9Incoming

Summary

Page for KANSL1 — KAT8 Regulatory NSL Complex Subunit 1

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🧬 Gene Info
Gene SymbolKANSL1
Full NameKAT8 Regulatory NSL Complex Subunit 1
AliasesKIAA1267, MSL1v1
Chromosome17q21.31
FunctionThe complex acetylates histone H4K16, a modification critical for chromatin decompaction and transcriptional activation[@cai2010].
Primary Expressionthe adult brain with highest levels in the cortex (particularly frontal and temporal lobes)
Molecular Weight121 kDa
Amino Acids105 aa
Exons16
PathwaysMitophagy
UniProt IDQ7Z3B3
NCBI Gene ID284058
Ensembl IDENSG00000120071
OMIM612452
GeneCardsKANSL1
Human Protein AtlasKANSL1
Associated DiseasesAlzheimer's disease, Neurodegeneration, Parkinson
InteractionsMAPT, APOE
KG Connections21 knowledge graph edges
DatabasesGeneCardsHPASTRING
🔮 Predicted Structure: KANSL1 — AlphaFold Q7Z3B3 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (5)

Knowledge base pages for this entity

Canonical Page

KANSL1 — KAT8 Regulatory NSL Complex Subunit 1

gene · 961 words

PSP vs CBS Phenotypic Divergence: Mechanistic Comparison

mechanism · 2338 words

KANSL1 Protein

protein · 628 words

Proteins

index · 296 words

Genes

index · 271 words

Pathway Diagram

graph TD
    KANSL1["<b>KANSL1</b>"]
    Parkinson{"Parkinson"}
    KANSL1 -->|"associated with"| Parkinson
    Neurodegeneration{"Neurodegeneration"}
    KANSL1 -->|"implicated in"| Neurodegeneration
    Heart_Failure{"Heart Failure"}
    KANSL1 -->|"regulates"| Heart_Failure
    PARKINSON["PARKINSON"]
    KANSL1 -->|"associated with"| PARKINSON
    KAT8["KAT8"]
    KANSL1 -->|"regulates"| KAT8
    GENES["GENES"]
    KANSL1 -->|"implicated in"| GENES
    MAPT["MAPT"]
    KANSL1 -->|"associated with"| MAPT
    Mitophagy(["Mitophagy"])
    KANSL1 -->|"regulates"| Mitophagy
    AUTOPHAGY["AUTOPHAGY"]
    KANSL1 -->|"associated with"| AUTOPHAGY
    Autophagy(["Autophagy"])
    KANSL1 -->|"associated with"| Autophagy
    neurodegeneration["neurodegeneration"]
    KANSL1 -->|"implicated in"| neurodegeneration
    PINK1["PINK1"]
    PINK1 -->|"regulates"| KANSL1
    MITOPHAGY["MITOPHAGY"]
    MITOPHAGY -->|"regulates"| KANSL1
    NEURODEGENERATION["NEURODEGENERATION"]
    NEURODEGENERATION -->|"implicated in"| KANSL1
    PARKINSON_S_DISEASE["PARKINSON'S DISEASE"]
    PARKINSON_S_DISEASE -->|"associated with"| KANSL1
    KAT8 -->|"regulates"| KANSL1
    AND["AND"]
    AND -->|"regulates"| KANSL1
    LYSOSOME["LYSOSOME"]
    LYSOSOME -->|"regulates"| KANSL1
    STX17["STX17"]
    STX17 -->|"regulates"| KANSL1
    style KANSL1 fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0

Outgoing (12)

TargetRelationTypeStr
Alzheimer's diseaseassociated_withdisease0.70
Parkinsonassociated_withdisease0.65
Neurodegenerationimplicated_indisease0.65
Heart Failureregulatesdisease0.65
KAT8regulatesgene0.60

Incoming (9)

SourceRelationTypeStr
PINK1regulatesgene0.60
KAT8regulatesgene0.60
STX17regulatesgene0.60
APOEinteracts_withgene0.60
MITOPHAGYregulatesgene0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

HypothesisScoreDiseaseAnalysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMIDAuthorsJournalYearCitations
No papers found