Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about KANSL1: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
| Gene Symbol | KANSL1 |
| Full Name | KAT8 Regulatory NSL Complex Subunit 1 |
| Aliases | KIAA1267, MSL1v1 |
| Chromosome | 17q21.31 |
| Function | The complex acetylates histone H4K16, a modification critical for chromatin decompaction and transcriptional activation[@cai2010]. |
| Primary Expression | the adult brain with highest levels in the cortex (particularly frontal and temporal lobes) |
| Molecular Weight | 121 kDa |
| Amino Acids | 105 aa |
| Exons | 16 |
| Pathways | Mitophagy |
| UniProt ID | Q7Z3B3 |
| NCBI Gene ID | 284058 |
| Ensembl ID | ENSG00000120071 |
| OMIM | 612452 |
| GeneCards | KANSL1 |
| Human Protein Atlas | KANSL1 |
| Associated Diseases | Alzheimer's disease, Neurodegeneration, Parkinson |
| Interactions | MAPT, APOE |
| KG Connections | 21 knowledge graph edges |
| Databases | GeneCardsHPASTRING |
Knowledge base pages for this entity
graph TD
KANSL1["<b>KANSL1</b>"]
Parkinson{"Parkinson"}
KANSL1 -->|"associated with"| Parkinson
Neurodegeneration{"Neurodegeneration"}
KANSL1 -->|"implicated in"| Neurodegeneration
Heart_Failure{"Heart Failure"}
KANSL1 -->|"regulates"| Heart_Failure
PARKINSON["PARKINSON"]
KANSL1 -->|"associated with"| PARKINSON
KAT8["KAT8"]
KANSL1 -->|"regulates"| KAT8
GENES["GENES"]
KANSL1 -->|"implicated in"| GENES
MAPT["MAPT"]
KANSL1 -->|"associated with"| MAPT
Mitophagy(["Mitophagy"])
KANSL1 -->|"regulates"| Mitophagy
AUTOPHAGY["AUTOPHAGY"]
KANSL1 -->|"associated with"| AUTOPHAGY
Autophagy(["Autophagy"])
KANSL1 -->|"associated with"| Autophagy
neurodegeneration["neurodegeneration"]
KANSL1 -->|"implicated in"| neurodegeneration
PINK1["PINK1"]
PINK1 -->|"regulates"| KANSL1
MITOPHAGY["MITOPHAGY"]
MITOPHAGY -->|"regulates"| KANSL1
NEURODEGENERATION["NEURODEGENERATION"]
NEURODEGENERATION -->|"implicated in"| KANSL1
PARKINSON_S_DISEASE["PARKINSON'S DISEASE"]
PARKINSON_S_DISEASE -->|"associated with"| KANSL1
KAT8 -->|"regulates"| KANSL1
AND["AND"]
AND -->|"regulates"| KANSL1
LYSOSOME["LYSOSOME"]
LYSOSOME -->|"regulates"| KANSL1
STX17["STX17"]
STX17 -->|"regulates"| KANSL1
style KANSL1 fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0| Target | Relation | Type | Str |
|---|---|---|---|
| Alzheimer's disease | associated_with | disease | 0.70 |
| Parkinson | associated_with | disease | 0.65 |
| Neurodegeneration | implicated_in | disease | 0.65 |
| Heart Failure | regulates | disease | 0.65 |
| KAT8 | regulates | gene | 0.60 |
| MAPT | associated_with | gene | 0.60 |
| MAPT | interacts_with | gene | 0.60 |
| PARKINSON | associated_with | gene | 0.60 |
| GENES | implicated_in | gene | 0.60 |
| Mitophagy | regulates | pathway | 0.60 |
| AUTOPHAGY | associated_with | gene | 0.60 |
| Autophagy | associated_with | pathway | 0.60 |
| Source | Relation | Type | Str |
|---|---|---|---|
| PINK1 | regulates | gene | 0.60 |
| KAT8 | regulates | gene | 0.60 |
| STX17 | regulates | gene | 0.60 |
| APOE | interacts_with | gene | 0.60 |
| MITOPHAGY | regulates | gene | 0.60 |
| NEURODEGENERATION | implicated_in | gene | 0.60 |
| PARKINSON'S DISEASE | associated_with | gene | 0.60 |
| AND | regulates | gene | 0.60 |
| LYSOSOME | regulates | gene | 0.60 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| No targeting hypotheses | |||
Scientific analyses that reference this entity
No analyses mention this entity
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||