gene

STX17

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about STX17: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

1121Connections

1Hypotheses

1Analyses

50Outgoing

50Incoming

Summary

STX17 is a gene implicated in neurodegeneration research. Key relationships include: associated with, interacts with, inhibits. Associated with ALS, Aging, Als. Connected to 545 entities in the SciDEX knowledge graph.

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🧬 Gene Info

Gene Symbol	STX17
Full Name	Syntaxin 17
Chromosome	9q31.3
Protein Type	Structural Protein
Target Class	Structural Protein
Function	STX17-targeting drugs would enhance or modulate autophagosome-lysosome fusion by facilitating SNARE complex assembly, thereby improving autophagic clearance of misfolded proteins and damaged organe...
Mechanism of Action	STX17-targeting drugs would enhance or modulate autophagosome-lysosome fusion by facilitating SNARE complex assembly, thereby improving autophagic clearance of misfolded proteins and damaged organelles. This mechanism is particularly relevant for neurodegenerative diseases characterized by protein aggregation.
Druggability	Medium (0.46)
Clinical Stage	Phase II
Pathways	Apoptosis, Autophagy, Cell Cycle, Lysosomal Degradation, Mitophagy
UniProt ID	Q9NYQ6
NCBI Gene ID	55276
Ensembl ID	ENSG00000143891
OMIM	612598
GeneCards	STX17
Human Protein Atlas	STX17
Associated Diseases	ALS, Aging, Alzheimer's disease, Cardiac, Ftd
Known Drugs/Compounds	donanemab, lecanemab, rapamycin
Interactions	ATG5, SQSTM1, NOS3, STING1, GLP1R, SREBF1
SciDEX Target	View Target Profile (8 clinical trials)
SciDEX Hypotheses	Autophagosome Maturation Checkpoint Control
KG Connections	1121 knowledge graph edges
Databases	GeneCards HPA STRING

🔮 Predicted Structure: STX17 — AlphaFold E9PQU9 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (21)

Knowledge base pages for this entity

Canonical Page

Pathway Diagram

graph TD
    STX17["STX17"] -->|"associated"| Glioblastoma["Glioblastoma"]
    STX17["STX17"] -->|"associated"| Tumor["Tumor"]
    STX17["STX17"] -->|"associated"| Parkinson["Parkinson"]
    STX17["STX17"] -->|"associated"| Ms["Ms"]
    STX17["STX17"] -->|"regulates"| Als["Als"]
    STX17["STX17"] -->|"interacts"| Aging["Aging"]
    VAMP8["VAMP8"] -->|"associated"| STX17["STX17"]
    LAMP2["LAMP2"] -->|"associated"| STX17["STX17"]
    GBM["GBM"] -->|"associated"| STX17["STX17"]
    LC3["LC3"] -->|"associated"| STX17["STX17"]
    style STX17 fill:#4a1a6b,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0

Outgoing (628)

Target	Relation	Type	Str
Autophagosome-Lysosome Fusion	mediates	process	0.95
ATG14	binds	protein	0.90
ER-Mitochondria Contact Site	associated_with	mechanism	0.90
Endoplasmic Reticulum Membrane Recruitment	mediates	process	0.90
Replicative Vacuole Formation	contributes_to	process	0.89
Autophagosome Formation	involved_in	process	0.85
Mitophagy	involved_in	process	0.85
Autophagy	involved_in	process	0.85
VAMP8	interacts_with	protein	0.80
Autophagosome-Lysosome Fusion	involved_in	process	0.80
ULK1	co_mentioned_with	gene	0.80
autophagy pathway	participates_in	pathway	0.80
ubiquitin-proteasome	participates_in	pathway	0.80
neural stem cells	activates	cell_type	0.80
STX17_protein	encodes	protein	0.80
Autophagy	regulates	pathway	0.80
Tumor	associated_with	disease	0.75
autophagosome-lysosome fusion	regulates	process	0.70
VAMP8	inhibits	gene	0.70
TFEB	regulates	gene	0.70
TP53	regulates	gene	0.70
Autophagy	activates	pathway	0.70
AUTOPHAGY	regulates	gene	0.70
neural stem cells	regulates	cell_type	0.70
Glioblastoma	associated_with	disease	0.65
Parkinson	associated_with	disease	0.65
Ms	associated_with	disease	0.65
Als	regulates	disease	0.65
Aging	interacts_with	disease	0.65
Als	interacts_with	disease	0.65
Neurodegeneration	therapeutic_target	disease	0.65
Aging	therapeutic_target	disease	0.65
Ms	regulates	disease	0.65
Als	therapeutic_target	disease	0.65
Cancer	regulates	disease	0.65
Tumor	regulates	disease	0.65
Tumor	interacts_with	disease	0.65
Hepatitis	interacts_with	disease	0.65
Parkinson	inhibits	disease	0.65
Als	associated_with	disease	0.65
Als	activates	disease	0.65
Ms	activates	disease	0.65
Carcinoma	activates	disease	0.65
Cancer	activates	disease	0.65
Aging	regulates	disease	0.65
Carcinoma	inhibits	disease	0.65
Ms	therapeutic_target	disease	0.65
Cardiac	associated_with	disease	0.65
Obesity	activates	disease	0.65
Inflammation	inhibits	disease	0.65

Incoming (493)

Source	Relation	Type	Str
zinc	inhibits	protein	0.90
h-5e68b4ad	targets_gene	hypothesis	0.90
Zinc	interacts_with	compound	0.85
SIDE	phosphorylates	protein	0.85
Acetylation	modulates	process	0.85
zinc influx	inhibits	phenotype	0.80
h-5e68b4ad	targets	hypothesis	0.80
MTOR	regulates	gene	0.80
MAP1LC3	regulates	gene	0.80
ATG	activates	gene	0.80
MAP1LC3	activates	gene	0.80
ATG	regulates	gene	0.80
RUBCNL	activates	gene	0.80
rapamycin	targets	drug	0.80
VAMP8	associated_with	gene	0.70
LC3	associated_with	gene	0.70
ULK1	associated_with	gene	0.70
SQSTM1	associated_with	gene	0.70
P62	associated_with	gene	0.70
SNAP29	associated_with	gene	0.70
TNF	associated_with	gene	0.70
LAMP1	associated_with	gene	0.70
RB1	activates	gene	0.70
GAPDH	regulates	gene	0.70
RB1	regulates	gene	0.70
SIRT1	regulates	gene	0.70
RB1CC1	regulates	gene	0.70
SNAP29	implicated_in	gene	0.70
CANCER	regulates	gene	0.70
CREB	activates	gene	0.70
AMPK	regulates	gene	0.70
CREB	regulates	gene	0.70
RAS	activates	gene	0.70
RAS	regulates	gene	0.70
MTORC1	activates	gene	0.70
MTORC1	regulates	gene	0.70
LAMP2	associated_with	gene	0.60
GBM	associated_with	gene	0.60
EPG5	associated_with	gene	0.60
OPTN	associated_with	gene	0.60
CALCOCO2	associated_with	gene	0.60
HSPA8	associated_with	gene	0.60
GABARAP	associated_with	gene	0.60
RTN3	associated_with	gene	0.60
DNM1L	associated_with	gene	0.60
MTOR	associated_with	gene	0.60
RAB2A	associated_with	gene	0.60
VAMP7	associated_with	gene	0.60
ATG14	interacts_with	gene	0.60
ELAVL2	therapeutic_target	gene	0.60

Targeting Hypotheses (1)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
Autophagosome Maturation Checkpoint Control	0.494	neurodegeneration	Autophagy-lysosome pathway convergence a

Mentioning Analyses (1)

Scientific analyses that reference this entity

Autophagy-lysosome pathway convergence across neurodegenerative diseases

neurodegeneration | 2026-04-01 | 7 hypotheses Top: 0.665

Related Papers (16)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
Systemic Neurodegeneration and Brain Aging: Multi-Omics Disintegration, Proteost [PMID:40868276]	Voicu V, Toader C, Șerban M, Covache-Bus	Biomedicines	2025	1
Acetylation in the regulation of autophagy. [PMID:35435793]	Xu Y, Wan W	Autophagy	2023	1
New insights regarding SNARE proteins in autophagosome-lysosome fusion. [PMID:32924745]	Tian X, Teng J, Chen J	Autophagy	2021	1
Autophagosomes form at ER-mitochondria contact sites. [PMID:23455425]	Hamasaki M, Furuta N, Matsuda A, Nezu A,	Nature	2013	1
SNX16 functions as a nutrient-sensitive regulator of autophagosomal components r [PMID:41593027]	Que H, Rong Y	Autophagy	2026	0
Downhill Running Blocks the Mitophagic Flux and Autophagosome-Lysosome Fusion in [PMID:41630123]	Deng H, Zheng S, Li M, Zhang D, Yang T,	Medicine and science in sports	2026	0
Rapid optogenetic manipulation of autophagy reveals that the nuclear pore comple [PMID:41676542]	Mondal P, Cyril A, Parham L, Mamriev D,	bioRxiv : the preprint server	2026	0
NK cell-derived GZMB (granzyme B) suppresses glioblastoma radioresistance by blo [PMID:41378763]	Yan J, Feng R, Qin Q, Shen G, Tian M, Li	Autophagy	2026	0
Unconventional secretion of PARK7 requires lysosomal delivery via chaperone-medi [PMID:40327696]	["Dash B", "Urano Y", "Mita Y", "Ashida	Proceedings of the National Ac	2025	0
CD147 promotes NSCLC metastasis by inducing secretory autophagy-dependent exosom [PMID:41413248]	Yang J, Liao C, Liang X, Ke Y, Sun Y, Hu	Cell death and differentiation	2025	0
Exosomes as nanocarriers for brain-targeted delivery of therapeutic nucleic acid [PMID:40533746]	["Sanadgol N", "Abedi M", "Hashemzaei M"	Journal of nanobiotechnology	2025	0
C9orf72 ALS-FTD: recent evidence for dysregulation of the autophagy-lysosome pat [PMID:33632058]	["Beckers J", "Tharkeshwar A", "Van Damm	Autophagy	2021	0
Automated Software System to Promote Anticoagulation and Reduce Stroke Risk: Clu [PMID:28119433]	["Holt T", "Dalton A", "Marshall T", "Fa	Stroke	2017	0
Evolutionarily conserved role and physiological relevance of a STX17/Syx17 (synt [PMID:24113031]	["Heged\u0171s K", "Tak\u00e1ts S", "Kov	Autophagy	2013	0
Eukaryotic stress granules are cleared by autophagy and Cdc48/VCP function. [PMID:23791177]	["Buchan J", "Kolaitis R", "Taylor J", "	Cell	2013	0
Actinic lichen nitidus. [PMID:25386247]	["Blalock T", "Kannan S", "Davis L"]	Dermatology reports	2010	0

STX17

Understanding Entity Pages

Summary

Wiki Pages (21)

STX17 Gene

Autophagy Mechanisms

Mitophagy Pathway in Neurodegeneration

Autophagy-Lysosomal Impairment Across Neurodegenerative Diseases

autophagy-lysosomal-alzheimers

Autophagy-Lysosomal Pathway in Parkinson's Disease

EPG5 Gene - Ectopic P-Granules 5 Autophagy Tutor

autophagy-lysosome-dysfunction

Endolysosomal Trafficking Defects in Neurodegeneration

Section 189: Advanced Autophagy-Endolysosomal Pathway Therapy in CBS/PSP

zinc-homeostasis-neurodegeneration

Mitochondria-Lysosome Contact Site (MLCS) Dysfunction Hypothesis in Parkinson's Disease

Autophagy-Lysosomal Pathway

Membrane Trafficking Pathway Dysfunction in Neurodegeneration

RAB39B Endosomal-Lysosomal Dysfunction PD Causal Chain

Mitophagy

Autophagy Types in Neurodegeneration

autophagy-lysosomal-ad

autophagy

Autophagy-Impaired Neurons