Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about KIF3B: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
Comprehensive coverage of KIF3B in axonal transport, neuronal development, ciliogenesis, and implications for Alzheimer's disease, Parkinson's disease, Joubert syndrome, and other neurodegenerative disorders.
| Gene Symbol | KIF3B |
| Full Name | Kinesin Family Member 3B |
| Chromosome | 20q11.21 |
| Function | KIF3B (Kinesin Family Member 3B) is the beta subunit of the heterotrimeric KIF3 motor complex, which also includes KIF3A and KAP3 |
| Amino Acids | 721 aa |
| Gene Type | Protein coding |
| UniProt ID | P49404 |
| NCBI Gene ID | 9377 |
| Ensembl ID | ENSG00000101955 |
| OMIM | 604530 |
| GeneCards | KIF3B |
| Human Protein Atlas | KIF3B |
| Associated Diseases | Alzheimer's disease, Parkinson's disease |
| KG Connections | 12 knowledge graph edges |
| Databases | GeneCardsHPASTRING |
Knowledge base pages for this entity
graph TD
KIF3B["<b>KIF3B</b>"]
Als{"Als"}
KIF3B -->|"expressed in"| Als
Ms{"Ms"}
KIF3B -->|"inhibits"| Ms
Neurodegeneration{"Neurodegeneration"}
KIF3B -->|"expressed in"| Neurodegeneration
APOPTOSIS["APOPTOSIS"]
KIF3B -->|"expressed in"| APOPTOSIS
OXIDATIVE_STRESS["OXIDATIVE STRESS"]
KIF3B -->|"expressed in"| OXIDATIVE_STRESS
Apoptosis(["Apoptosis"])
KIF3B -->|"expressed in"| Apoptosis
Oxidative_Stress(["Oxidative Stress"])
KIF3B -->|"expressed in"| Oxidative_Stress
neurodegeneration["neurodegeneration"]
KIF3B -->|"implicated in"| neurodegeneration
ICAM1["ICAM1"]
ICAM1 -->|"expressed in"| KIF3B
NEURODEGENERATION["NEURODEGENERATION"]
NEURODEGENERATION -->|"expressed in"| KIF3B
BAG1["BAG1"]
BAG1 -->|"expressed in"| KIF3B
ASTROCYTES["ASTROCYTES"]
ASTROCYTES -->|"expressed in"| KIF3B
SOD1["SOD1"]
SOD1 -->|"expressed in"| KIF3B
style KIF3B fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0| Target | Relation | Type | Str |
|---|---|---|---|
| Als | expressed_in | disease | 0.65 |
| Ms | inhibits | disease | 0.65 |
| Neurodegeneration | expressed_in | disease | 0.65 |
| APOPTOSIS | expressed_in | gene | 0.60 |
| OXIDATIVE STRESS | expressed_in | gene | 0.60 |
| Apoptosis | expressed_in | pathway | 0.60 |
| Oxidative Stress | expressed_in | pathway | 0.60 |
| Source | Relation | Type | Str |
|---|---|---|---|
| ICAM1 | expressed_in | gene | 0.60 |
| BAG1 | expressed_in | gene | 0.60 |
| SOD1 | expressed_in | gene | 0.60 |
| NEURODEGENERATION | expressed_in | gene | 0.60 |
| ASTROCYTES | expressed_in | gene | 0.60 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| No targeting hypotheses | |||
Scientific analyses that reference this entity
No analyses mention this entity
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||