gene

KIF3B

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about KIF3B: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

12Connections
0Hypotheses
0Analyses
7Outgoing
5Incoming

Summary

Comprehensive coverage of KIF3B in axonal transport, neuronal development, ciliogenesis, and implications for Alzheimer's disease, Parkinson's disease, Joubert syndrome, and other neurodegenerative disorders.

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🧬 Gene Info
Gene SymbolKIF3B
Full NameKinesin Family Member 3B
Chromosome20q11.21
FunctionKIF3B (Kinesin Family Member 3B) is the beta subunit of the heterotrimeric KIF3 motor complex, which also includes KIF3A and KAP3
Amino Acids721 aa
Gene TypeProtein coding
UniProt IDP49404
NCBI Gene ID9377
Ensembl IDENSG00000101955
OMIM604530
GeneCardsKIF3B
Human Protein AtlasKIF3B
Associated DiseasesAlzheimer's disease, Parkinson's disease
KG Connections12 knowledge graph edges
DatabasesGeneCardsHPASTRING
🔮 Predicted Structure: KIF3B — AlphaFold P49404 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (6)

Knowledge base pages for this entity

Canonical Page

KIF3B — Kinesin Family Member 3B

gene · 2177 words

KIF3A — Kinesin Family Member 3A

gene · 2701 words

KIF3C — Kinesin Family Member 3C

gene · 944 words

BAG1 Gene

gene · 648 words

KIF3C Protein

protein · 635 words

Genes

index · 271 words

Pathway Diagram

graph TD
    KIF3B["<b>KIF3B</b>"]
    Als{"Als"}
    KIF3B -->|"expressed in"| Als
    Ms{"Ms"}
    KIF3B -->|"inhibits"| Ms
    Neurodegeneration{"Neurodegeneration"}
    KIF3B -->|"expressed in"| Neurodegeneration
    APOPTOSIS["APOPTOSIS"]
    KIF3B -->|"expressed in"| APOPTOSIS
    OXIDATIVE_STRESS["OXIDATIVE STRESS"]
    KIF3B -->|"expressed in"| OXIDATIVE_STRESS
    Apoptosis(["Apoptosis"])
    KIF3B -->|"expressed in"| Apoptosis
    Oxidative_Stress(["Oxidative Stress"])
    KIF3B -->|"expressed in"| Oxidative_Stress
    neurodegeneration["neurodegeneration"]
    KIF3B -->|"implicated in"| neurodegeneration
    ICAM1["ICAM1"]
    ICAM1 -->|"expressed in"| KIF3B
    NEURODEGENERATION["NEURODEGENERATION"]
    NEURODEGENERATION -->|"expressed in"| KIF3B
    BAG1["BAG1"]
    BAG1 -->|"expressed in"| KIF3B
    ASTROCYTES["ASTROCYTES"]
    ASTROCYTES -->|"expressed in"| KIF3B
    SOD1["SOD1"]
    SOD1 -->|"expressed in"| KIF3B
    style KIF3B fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0

Outgoing (7)

TargetRelationTypeStr
Alsexpressed_indisease0.65
Msinhibitsdisease0.65
Neurodegenerationexpressed_indisease0.65
APOPTOSISexpressed_ingene0.60
OXIDATIVE STRESSexpressed_ingene0.60

Incoming (5)

SourceRelationTypeStr
ICAM1expressed_ingene0.60
BAG1expressed_ingene0.60
SOD1expressed_ingene0.60
NEURODEGENERATIONexpressed_ingene0.60
ASTROCYTESexpressed_ingene0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

HypothesisScoreDiseaseAnalysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMIDAuthorsJournalYearCitations
No papers found