concept

KLHL22

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about KLHL22: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

32Connections

0Hypotheses

0Analyses

21Outgoing

10Incoming

No summary available yet. View on Wiki →

💡 Concept Info

Name	KLHL22
Key Genes/Proteins	DEPDC5, MTORC1, NPRL2, NPRL3, CANCER
Related Diseases	Ageing, Breast Cancer, Tumor, Cancer, ALS
Related Pathways	Mtor

Pathway Diagram

graph TD
    KLHL22["KLHL22"]
    KLHL22 -->|"degrades"| DEPDC5["DEPDC5"]
    KLHL22 -->|"activates"| MTORC1["MTORC1"]
    KLHL22 -.biomarker for.-> Breast_Cancer["Breast Cancer"]
    KLHL22 -->|"activates"| Tumor["Tumor"]
    KLHL22 -->|"inhibits"| Cancer["Cancer"]
    KLHL22 -->|"activates"| ALS["ALS"]
    KLHL22 -->|"activates"| Als["Als"]
    LYSOSOME["LYSOSOME"] -->|"activates"| KLHL22
    CUL3["CUL3"] -->|"activates"| KLHL22
    DEPDC5 -->|"activates"| KLHL22
    UBIQUITIN["UBIQUITIN"] -->|"activates"| KLHL22
    AND["AND"] -->|"activates"| KLHL22
    MTORC1 -->|"activates"| KLHL22
    CANCER["CANCER"] -->|"inhibits"| KLHL22
    NPRL3["NPRL3"] -->|"activates"| KLHL22

Outgoing (22)

Target	Relation	Type	Str
DEPDC5	degrades	protein	0.95
MTORC1	activates	protein	0.95
Tumorigenesis	associated_with	process	0.90
Ageing	associated_with	disease	0.85
Breast Cancer	associated_with	disease	0.85
Breast Cancer	targets	disease	0.80
Tumor	activates	disease	0.65
Cancer	inhibits	disease	0.65
ALS	activates	disease	0.65
Als	activates	disease	0.65
Cancer	therapeutic_target	disease	0.65
NPRL2	activates	gene	0.60
NPRL3	activates	gene	0.60
CANCER	inhibits	gene	0.60
Mtor	activates	pathway	0.60
UBIQUITIN	activates	gene	0.60
DEPDC5	activates	gene	0.60
AND	activates	gene	0.60
LYSOSOME	activates	gene	0.60
ubiquitin-proteasome	participates_in	pathway	0.60
autophagy pathway	participates_in	pathway	0.60

Incoming (10)

Source	Relation	Type	Str
LYSOSOME	activates	gene	0.60
CUL3	activates	gene	0.60
DEPDC5	activates	gene	0.60
UBIQUITIN	activates	gene	0.60
AND	activates	gene	0.60
MTORC1	activates	gene	0.60
CANCER	inhibits	gene	0.60
NPRL3	activates	gene	0.60
NPRL2	activates	gene	0.60
DEPDC5	associated_with	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found