CUL3

Understanding Entity Pages

This page aggregates everything SciDEX knows about CUL3: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

Summary

CUL3 is a gene implicated in neurodegeneration research. Key relationships include: activates, interacts with, expressed in. Associated with ALS, Aging, Als. Connected to 151 entities in the SciDEX knowledge graph.

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graph TD
    CUL3["CUL3<br/>Cullin 3 E3 Ligase"] -->|"regulates"| KEAP1["KEAP1"]
    CUL3 -->|"regulates"| NRF2["NRF2 Pathway"]
    CUL3 -->|"regulates"| Akt["AKT Signaling"]
    CUL3 -->|"activates"| BACH1["BACH1"]
    CUL3 -->|"regulates"| FYN["FYN Kinase"]
    CUL3 -->|"activates"| MTOR["mTOR Pathway"]
    CUL3 -->|"activates"| DEPDC5["DEPDC5"]
    CUL3 -->|"activates"| NPRL2["NPRL2"]

    CUL3 -->|"inhibits"| BECN1["BECN1/Autophagy"]
    CUL3 -->|"activates"| Apoptosis["Apoptosis"]

    AKT2["AKT"] -->|"activates"| CUL3
    BACH1 -->|"activates"| CUL3

    CUL3 -->|"regulates"| Cancer["Cancer"]
    CUL3 -->|"regulates"| ALS["ALS"]
    CUL3 -->|"associated with"| Methylation["DNA Methylation"]

    style CUL3 fill:#e74c3c,stroke:#c0392b,color:#e0e0e0
    style KEAP1 fill:#3498db,stroke:#2980b9,color:#e0e0e0
    style NRF2 fill:#3498db,stroke:#2980b9,color:#e0e0e0
    style MTOR fill:#2ecc71,stroke:#27ae60,color:#e0e0e0
    style Cancer fill:#9b59b6,stroke:#8e44ad,color:#e0e0e0