protein

LC3PROTEIN

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about LC3PROTEIN: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

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Summary

LC3 belongs to the ATG8 family of proteins and undergoes post-translational modifications essential for its function.

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🔬 Protein Info

Gene Symbol	LC3PROTEIN
Full Name	Microtubule-Associated Protein 1 Light Chain 3
Function	is a fundamental protein in the autophagy pathway and serves as a key marker for autophagosome formation.
Primary Expression	various tissues - LC3B (MAP1LC3B) - the most studied isoform, commonly used as an autophagy marker - LC3C (MAP1LC3C) - more restricted express
Molecular Weight	~17 kDa
UniProt ID	Q9GZF4 (LC3A), Q9GZY8 (LC3B)
GeneCards	LC3PROTEIN
Human Protein Atlas	LC3PROTEIN
GABARAP and GATE-16	related proteins in the ATG8 family[@shpilka2021]
Associated Diseases	AD, Aging, ALI, Als, Alzheimer
Known Drugs/Compounds	ATTECs, CISPLATIN, dimethyl fumarate, licorice, nicotinamide, rapamycin
Interactions	6-OHDA, ABCA1, ABCD3, ABCG1, ABP, ACAT1
KG Connections	3247 knowledge graph edges
Databases	GeneCards NCBI Gene HPA STRING

🔮 Predicted Structure: LC3PROTEIN — AlphaFold Q9GZF4 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (1)

Knowledge base pages for this entity

Canonical Page

LC3 (Microtubule-Associated Protein 1 Light Chain 3)

protein · 724 words

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Pathway Diagram

graph TD
    LC3PROTEIN["LC3PROTEIN"]
    neurodegeneration["neurodegeneration"]
    LC3PROTEIN -->|"implicated_in"| neurodegeneration
    style LC3PROTEIN fill:#4a1a6b,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0

Outgoing (0)

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Incoming (0)

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Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

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Mentioning Analyses (0)

Scientific analyses that reference this entity

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Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
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Debates (0)

Multi-agent debates referencing this entity

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Related Research

Hypotheses and analyses mentioning LC3PROTEIN in their description or question text

No additional research found