concept

LYC

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about LYC: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

12Connections
7Hypotheses
6Analyses
6Outgoing
0Incoming

No summary available yet. View on Wiki →

💡 Concept Info
NameLYC
Key Genes/ProteinsAKT, BECN1, MAP1LC3, PINK1, PRKN
Related Pathwaysautophagy
Linked Hypotheses8 hypotheses

Wiki Pages (1)

Knowledge base pages for this entity

akt-protein

protein · 1305 words

Pathway Diagram

flowchart TD
    N0["LYC"]
    N1["AKT"]
    N0 -->|"inhibits"| N1
    N2["autophagy"]
    N0 -->|"activates"| N2
    N3["Renal Fibrosis"]
    N0 -->|"treats"| N3
    N4["Mitophagy"]
    N0 -->|"activates"| N4
    N5["BECN1"]
    N0 -->|"contributes to"| N5
    N6["MAP1LC3"]
    N0 -->|"contributes to"| N6

    classDef gene fill:#1a3a2a,stroke:#4caf50,color:#e0e0e0
    classDef protein fill:#1a2a3a,stroke:#4fc3f7,color:#e0e0e0
    classDef disease fill:#3a1a1a,stroke:#ef5350,color:#e0e0e0
    classDef pathway fill:#2a1a3a,stroke:#ce93d8,color:#e0e0e0
    classDef mechanism fill:#2a2a1a,stroke:#ffd54f,color:#e0e0e0
    classDef drug fill:#1a2a2a,stroke:#26c6da,color:#e0e0e0
    classDef cell_type fill:#2a1a2a,stroke:#ab47bc,color:#e0e0e0
    classDef phenotype fill:#2a2a1a,stroke:#ffa726,color:#e0e0e0
    classDef process fill:#1a2a2a,stroke:#66bb6a,color:#e0e0e0
    classDef biological_process fill:#1a2a2a,stroke:#66bb6a,color:#e0e0e0
    classDef concept fill:#1a1a2a,stroke:#7986cb,color:#e0e0e0
    classDef entity fill:#1a2a3a,stroke:#4fc3f7,color:#e0e0e0
    classDef therapeutic fill:#1a2a2a,stroke:#26c6da,color:#e0e0e0
    classDef index fill:#1a1a2a,stroke:#7986cb,color:#e0e0e0
    class N0 concept
    class N1 protein
    class N2 pathway
    class N3 disease
    class N4 process
    class N5 gene
    class N6 gene

Outgoing (12)

TargetRelationTypeStr
AKTinhibitsprotein0.90
autophagyactivatespathway0.90
BECN1contributes_togene0.80
MAP1LC3contributes_togene0.80
PINK1regulatesgene0.70

Incoming (0)

SourceRelationTypeStr
No incoming edges

Targeting Hypotheses (7)

Hypotheses where this entity is a therapeutic target

HypothesisScoreDiseaseAnalysis
Dual-Phase Medium-Chain Triglyceride Intervention 0.506 neurodegeneration How do astrocyte-neuron metabolic intera
Endothelial Glycocalyx Regeneration via Syndecan-1 Upregulat 0.505 neurodegeneration Perivascular spaces and glymphatic clear
Glycosaminoglycan Template Disruption Approach 0.464 neurodegeneration Protein aggregation cross-seeding across
Glycine-Rich Domain Competitive Inhibition 0.429 neurodegeneration TDP-43 phase separation therapeutics for
Glial Glycocalyx Remodeling Therapy 0.415 neurodegeneration 4R-tau strain-specific spreading pattern
Metabolic Reprogramming via Microglial Glycolysis Inhibition 0.385 neurodegeneration Synaptic pruning by microglia in early A
Pharmacological Enhancement of APOE4 Glycosylation 0.366 neurodegeneration APOE4 structural biology and therapeutic

Mentioning Analyses (6)

Scientific analyses that reference this entity

Does TRT-induced erythrocytosis actually increase venous thromboembolism risk in

endocrinology | 2026-04-13 | 2 hypotheses Top: 0.572

Which specific metabolic pathways in APOE4 microglia are causally linked to dysf

neurodegeneration | 2026-04-11 | 0 hypotheses

Do tau-containing vesicles exhibit distinct surface glycosylation patterns compa

neurodegeneration | 2026-04-10 | 0 hypotheses

Do tau-containing vesicles exhibit unique surface glycosylation patterns that di

neurodegeneration | 2026-04-09 | 0 hypotheses

Quantitative proteomics of the aging synapse in early Alzheimer disease

neurodegeneration | 2026-04-04 | 0 hypotheses

Related Papers (20)

Scientific publications cited in analyses involving this entity

Title & PMIDAuthorsJournalYearCitations
Autophagy and ALS: mechanistic insights and therapeutic implications. [PMID:34057020] Chua JP, De Calbiac H, Kabashi E, Barmad Autophagy 2022 2
TDP-43 Pathology in Alzheimer's Disease. [PMID:34930382] Meneses A, Koga S, O'Leary J, Dickson DW Mol Neurodegener 2021 2
Protein transmission in neurodegenerative disease. [PMID:32203399] Peng C, Trojanowski JQ, Lee VM Nat Rev Neurol 2020 2
TDP-43 Triggers Mitochondrial DNA Release via mPTP to Activate cGAS/STING in ALS [PMID:33031745] Yu CH, Davidson S, Harapas CR, Hilton JB Cell 2020 2
Trehalose induces autophagy via lysosomal-mediated TFEB activation in models of [PMID:30335591] Rusmini P, Cortese K, Crippa V, Cristofa Autophagy 2019 2
Bergenin attenuates traumatic brain injury via inhibition of microglial PFKFB3-d [PMID:41520557] Sun B, Zhang A, Feng S, Jamali AW, Jia Z Int Immunopharmacol 2026 1
HK1 and HK2 Beyond Glycolysis: Mitochondrial Interactions and Dual Roles in Meta [PMID:41387352] Pesce NA, Seminara G, Giarrusso G, Tomas Adv Biol (Weinh) 2026 1
Glucose Metabolic Reprogramming in Microglia: Implications for Neurodegenerative [PMID:39987285] Fang M, Zhou Y, He K, Lu Y, Tao F, Huang Mol Neurobiol 2025 1
Deficiency of Microglial Hv1 Protects Against Lipopolysaccharide-Induced Neuroin [PMID:40911376] Sun L, Wang X, Guan S, Zhang P, Chen D, FASEB J 2025 1
The PI3K/Akt Pathway and Glucose Metabolism: A Dangerous Liaison in Cancer. [PMID:38904014] Fontana F, Giannitti G, Marchesi S, Limo Int J Biol Sci 2024 1
AST-120 alleviates renal ischemia-reperfusion injury by inhibiting HK2-mediated [PMID:39217289] Zhou J, Zhang J, Xu F, Gao H, Wang L, Zh Mol Med 2024 1
Endogenous stimuli-responsive separating microneedles to inhibit hypertrophic sc [PMID:38448448] Yang ZR, Suo H, Fan JW, Lv N, Du K, Ma T Nat Commun 2024 1
The extracellular matrix component perlecan/HSPG2 regulates radioresistance in p [PMID:39149513] Samaržija I, Lukiyanchuk V, Lončarić M, Front Cell Dev Biol 2024 1
NETs induce ferroptosis of endothelial cells in LPS-ALI through SDC-1/HS and dow [PMID:38677244] Fei Y, Huang X, Ning F, Qian T, Cui J, W Biomed Pharmacother 2024 1
Hexokinase 2-mediated gene expression via histone lactylation is required for he [PMID:37463576] Rho H, Terry AR, Chronis C, Hay N Cell Metab 2023 1
N protein of PEDV plays chess game with host proteins by selective autophagy. [PMID:36861818] Zhai X, Kong N, Zhang Y, Song Y, Qin W, Autophagy 2023 1
PIKFYVE inhibition mitigates disease in models of diverse forms of ALS. [PMID:36754049] Hung ST, Linares GR, Chang WH, Eoh Y, Kr Cell 2023 1
Genetic regulation of post-translational modification of two distinct proteins. [PMID:35332118] Landini A, Trbojević-Akmačić I, Navarro Nat Commun 2022 1
Divergent Golgi trafficking limits B cell-mediated IgG sialylation. [PMID:35726710] Glendenning LM, Zhou JY, Reynero KM, Cob J Leukoc Biol 2022 1
APRIL limits atherosclerosis by binding to heparan sulfate proteoglycans. [PMID:34433968] Tsiantoulas D, Eslami M, Obermayer G, Cl Nature 2021 1