concept

LATE-ONSET ALZHEIMER'S DISEASE

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about LATE-ONSET ALZHEIMER'S DISEASE: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

29Connections

0Hypotheses

0Analyses

1Outgoing

28Incoming

No summary available yet. View on Wiki →

💡 Concept Info

Name	LATE-ONSET ALZHEIMER'S DISEASE

Wiki Pages (20)

Knowledge base pages for this entity

Pathway Diagram

graph TD
    LATE_ONSET_ALZHEIMER_S_DISEASE["LATE-ONSET ALZHEIMER'S DISEASE"]
    LATE_ONSET_ALZHEIMER_S_DISEASE -->|"causes"| Molecular_Interaction_Structur["Molecular Interaction Structure"]
    APOE4["APOE4"] -->|"risk_factor_for"| LATE_ONSET_ALZHEIMER_S_DISEASE
    BIN1["BIN1"] -->|"risk_factor_for"| LATE_ONSET_ALZHEIMER_S_DISEASE
    APOE["APOE"] -->|"risk_factor_for"| LATE_ONSET_ALZHEIMER_S_DISEASE
    TREM2["TREM2"] -->|"risk_factor_for"| LATE_ONSET_ALZHEIMER_S_DISEASE
    Decreased_Lipidated_ApoE_LDLR_["Decreased Lipidated ApoE-LDLR Interaction"] -.protects against.-> LATE_ONSET_ALZHEIMER_S_DISEASE
    R47H["R47H"] -->|"risk_factor_for"| LATE_ONSET_ALZHEIMER_S_DISEASE

Outgoing (1)

Target	Relation	Type	Str
Molecular Interaction Structure	causes	mechanism	0.83

Incoming (28)

Source	Relation	Type	Str
APOE4	risk_factor_for	gene	0.98
APOE4	risk_factor_for	protein	0.95
BIN1	risk_factor_for	gene	0.95
APOE	risk_factor_for	gene	0.95
TREM2	risk_factor_for	gene	0.95
TYROBP	associated_with	gene	0.95
APOE	risk_factor_for	gene	0.95
BIN1	risk_factor_for	gene	0.95
APOE	risk_factor_for	gene	0.95
Astrocytic Bioenergetic Failure	causes	mechanism	0.95
INPP5D	risk_factor_for	gene	0.93
Immune and Microglia Module	associated_with	pathway	0.92
Decreased Lipidated ApoE-LDLR Interaction	protects_against	mechanism	0.92
Neuroinflammation	contributes_to	process	0.92
R47H	risk_factor_for	biomarker	0.90
Decreased Lipidated Apoe-Ldlr Interactions	protects_against	mechanism	0.90
APOE4	associated_with	protein	0.90
TREM2	risk_factor_for	gene	0.90
TREM2	risk_factor_for	gene	0.90
Gene-Regulatory Networks	associated_with	pathway	0.88
UNC5C	associated_with	gene	0.85
LRP1	associated_with	gene	0.85
Inflammatory Pathway	involved_in	pathway	0.85
COMPLEMENT GENES	risk_factor_for	gene	0.85
Microglial Pathway	involved_in	pathway	0.80
genetic risk loci	associated_with	gene	0.70
CR1	therapeutic_target	gene	0.60
INPP5D	biomarker_for	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

LATE-ONSET ALZHEIMER'S DISEASE

Understanding Entity Pages

Wiki Pages (20)

Microglial Cells — Cell Type Hierarchy

Tauopathies

RNA Therapeutics for Neurodegeneration Investment Landscape

Braak Staging and Tau Propagation Pathway

Autophagy-Lysosomal Impairment Across Neurodegenerative Diseases

genetics

Glymphatic System Dysfunction in Neurodegeneration

CR1 Gene — Complement Component 1q Receptor

PSEN2 — Presenilin 2

al002-trem2-agonist-alzheimers

MS4A4A Gene — Membrane-Spanning 4-Domains A4A

Endolysosomal Trafficking Defects in Neurodegeneration

Astrocyte-Neuron Metabolic Coupling Pathway

BIN1 — Bridging Integrator 1

trem2-therapeutics

SORL1 Protein

SORL1 Gene

CD33 — Cluster of Differentiation 33