Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about GENETIC RISK LOCI: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
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| Name | GENETIC RISK LOCI |
| Key Genes/Proteins | TREM2, IL6 |
| Related Diseases | Alzheimer, Dementia, Ms, Inflammation, Breast Cancer |
Knowledge base pages for this entity
graph TD
GENETIC_RISK_LOCI["GENETIC RISK LOCI"]
GENETIC_RISK_LOCI -->|"target for"| Dementia["Dementia"]
GENETIC_RISK_LOCI -->|"target for"| Inflammation["Inflammation"]
GENETIC_RISK_LOCI -.biomarker for.-> Breast_Cancer["Breast Cancer"]
GENETIC_RISK_LOCI -.biomarker for.-> Cancer["Cancer"]
GENETIC_RISK_LOCI -->|"regulates"| Alzheimer["Alzheimer"]
GENETIC_RISK_LOCI -->|"regulates"| Neuroinflammation["Neuroinflammation"]
GENETIC_RISK_LOCI -->|"regulates"| Amyotrophic_Lateral_Sclerosis["Amyotrophic Lateral Sclerosis"]
GENETIC_RISK_LOCI -->|"regulates"| Aging["Aging"]
GUCY1B1["GUCY1B1"] -->|"regulates"| GENETIC_RISK_LOCI
NFKBIA["NFKBIA"] -->|"regulates"| GENETIC_RISK_LOCI
GASDERMIN["GASDERMIN"] -->|"regulates"| GENETIC_RISK_LOCI
NEUROINFLAMMATION["NEUROINFLAMMATION"] -->|"regulates"| GENETIC_RISK_LOCI| Target | Relation | Type | Str |
|---|---|---|---|
| Alzheimer | associated_with | disease | 0.75 |
| Dementia | associated_with | disease | 0.65 |
| Ms | associated_with | disease | 0.65 |
| Dementia | therapeutic_target | disease | 0.65 |
| Inflammation | therapeutic_target | disease | 0.65 |
| Breast Cancer | biomarker_for | disease | 0.65 |
| Cancer | biomarker_for | disease | 0.65 |
| Als | associated_with | disease | 0.65 |
| Alzheimer | regulates | disease | 0.65 |
| Neuroinflammation | regulates | disease | 0.65 |
| Amyotrophic Lateral Sclerosis | regulates | disease | 0.65 |
| Aging | regulates | disease | 0.65 |
| Inflammation | regulates | disease | 0.65 |
| TREM2 | associated_with | gene | 0.60 |
| IL6 | associated_with | gene | 0.60 |
| ZCWPW1 | associated_with | gene | 0.60 |
| AD RISK LOCI | associated_with | gene | 0.60 |
| ALZHEIMER'S DISEASE | associated_with | gene | 0.60 |
| CTSH | associated_with | gene | 0.60 |
| PILRB | associated_with | gene | 0.60 |
| GBA | associated_with | gene | 0.60 |
| CR1 | associated_with | gene | 0.60 |
| ALZHEIMER | associated_with | gene | 0.60 |
| INFLAMMATION | therapeutic_target | gene | 0.60 |
| APOE | therapeutic_target | gene | 0.60 |
| DEMENTIA | therapeutic_target | gene | 0.60 |
| Immune Response | therapeutic_target | pathway | 0.60 |
| CANCER | biomarker_for | gene | 0.60 |
| GENES | associated_with | gene | 0.60 |
| ALZHEIMER | regulates | gene | 0.60 |
| MEF2C | regulates | gene | 0.60 |
| RBFOX2 | regulates | gene | 0.60 |
| RNA | regulates | gene | 0.60 |
| AND | regulates | gene | 0.60 |
| ALZHEIMER'S DISEASE | regulates | gene | 0.60 |
| AMYLOID | regulates | gene | 0.60 |
| TAU | regulates | gene | 0.60 |
| Amyloid | regulates | pathway | 0.60 |
| CYTOKINES | regulates | gene | 0.60 |
| ZBP1 | regulates | gene | 0.60 |
| ROS | regulates | gene | 0.60 |
| MICROGLIA | expressed_in | gene | 0.60 |
| AGING | regulates | gene | 0.60 |
| RIPK1 | regulates | gene | 0.60 |
| TDP-43 | regulates | gene | 0.60 |
| NLRP3 | regulates | gene | 0.60 |
| PROINFLAMMATORY CYTOKINES | regulates | gene | 0.60 |
| INPP5D | regulates | gene | 0.60 |
| GENES | expressed_in | gene | 0.60 |
| AMYOTROPHIC LATERAL SCLEROSIS | regulates | gene | 0.60 |
| Source | Relation | Type | Str |
|---|---|---|---|
| CR2 | associated_with | gene | 0.60 |
| ALZHEIMER DISEASE | associated_with | gene | 0.60 |
| GUCY1B1 | regulates | gene | 0.60 |
| NFKBIA | regulates | gene | 0.60 |
| GASDERMIN | regulates | gene | 0.60 |
| NEUROINFLAMMATION | regulates | gene | 0.60 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| No targeting hypotheses | |||
Scientific analyses that reference this entity
No analyses mention this entity
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||