Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about lissencephaly: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
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| Associated Genes | REELIN |
| KG Connections | 15 knowledge graph edges |
| Databases | OMIMOrphanetClinicalTrialsPubMed |
Knowledge base pages for this entity
graph TD
LISSENCEPHALY["LISSENCEPHALY"]
LISSENCEPHALY -->|"interacts"| SCHIZOPHRENIA["SCHIZOPHRENIA"]
LISSENCEPHALY -->|"mediates"| REELIN["REELIN"]
LISSENCEPHALY -->|"causes"| Neuron["Neuron"]
LISSENCEPHALY -->|"causes"| NEURONS["NEURONS"]
LISSENCEPHALY -->|"interacts"| ALZHEIMER["ALZHEIMER"]
REELIN -->|"interacts"| LISSENCEPHALY
AUTISM["AUTISM"] -->|"interacts"| LISSENCEPHALY
DEPRESSION["DEPRESSION"] -->|"interacts"| LISSENCEPHALY
EPILEPSY["EPILEPSY"] -->|"interacts"| LISSENCEPHALY| Target | Relation | Type | Str |
|---|---|---|---|
| REELIN | associated_with | protein | 0.50 |
| REELIN | interacts_with | protein | 0.50 |
| Neuron | causes | cell_type | 0.50 |
| NEURONS | causes | concept | 0.50 |
| SCHIZOPHRENIA | interacts_with | disease | 0.50 |
| ALZHEIMER | interacts_with | gene | 0.50 |
| Alzheimer'S Disease | interacts_with | disease | 0.50 |
| disease | interacts_with | disease | 0.50 |
| Bipolar | interacts_with | disease | 0.50 |
| ALZHEIMER'S | interacts_with | concept | 0.50 |
| Source | Relation | Type | Str |
|---|---|---|---|
| REELIN | implicated_in | protein | 0.80 |
| Reelin Signaling Pathway | associated_with | pathway | 0.80 |
| AUTISM | interacts_with | disease | 0.50 |
| DEPRESSION | interacts_with | disease | 0.50 |
| EPILEPSY | interacts_with | gene | 0.50 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| No targeting hypotheses | |||
Scientific analyses that reference this entity
No analyses mention this entity
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||