disease

AUTISM

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about AUTISM: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

939Connections

0Hypotheses

1Analyses

50Outgoing

42Incoming

No summary available yet. View on Wiki →

Disease Info

Associated Genes	REELIN, PVALB, CLOCK, MTNR1A, MTNR1B, SST
Therapeutic Agents	MELATONIN
KG Connections	254 knowledge graph edges
Databases	OMIM Orphanet ClinicalTrials PubMed

Wiki Pages (20)

Knowledge base pages for this entity

AAV Gene Therapy for Neurodevelopmental Epilepsy — Competitive Landscape & Delivery Alternatives

therapeutic · 15567 words

→

Pathway Diagram

graph TD
    AUTISM["AUTISM"] -->|"expressed in"| BDNF["BDNF"]
    style BDNF fill:#1a2a3a,stroke:#ce93d8,stroke-width:1px,color:#e0e0e0
    AUTISM["AUTISM"] -->|"expressed in"| WNT["WNT"]
    style WNT fill:#1a2a3a,stroke:#ce93d8,stroke-width:1px,color:#e0e0e0
    AUTISM["AUTISM"] -->|"regulates"| LEWY_BODY["LEWY BODY"]
    style LEWY_BODY fill:#1a2a3a,stroke:#ef5350,stroke-width:1px,color:#e0e0e0
    AUTISM["AUTISM"] -->|"causes"| MICROGLIA["MICROGLIA"]
    style MICROGLIA fill:#1a2a3a,stroke:#4fc3f7,stroke-width:1px,color:#e0e0e0
    AUTISM["AUTISM"] -->|"causes"| SYNAPTIC_PLASTICITY["SYNAPTIC PLASTICITY"]
    style SYNAPTIC_PLASTICITY fill:#1a2a3a,stroke:#ffd54f,stroke-width:1px,color:#e0e0e0
    AUTISM["AUTISM"] -->|"associated"| MITOCHONDRIAL_DYSFUNCTION["MITOCHONDRIAL DYSFUNCTION"]
    style MITOCHONDRIAL_DYSFUNCTION fill:#1a2a3a,stroke:#ffd54f,stroke-width:1px,color:#e0e0e0
    AUTISM["AUTISM"] -->|"interacts"| DEPRESSION["DEPRESSION"]
    style DEPRESSION fill:#1a2a3a,stroke:#4fc3f7,stroke-width:1px,color:#e0e0e0
    RELN["RELN"] -->|"implicated in"| AUTISM["AUTISM"]
    style RELN fill:#1a2a3a,stroke:#4fc3f7,stroke-width:1px,color:#e0e0e0
    ALZHEIMER_S["ALZHEIMER'S"] -->|"associated"| AUTISM["AUTISM"]
    style ALZHEIMER_S fill:#1a2a3a,stroke:#ef5350,stroke-width:1px,color:#e0e0e0
    REELIN["REELIN"] -->|"interacts"| AUTISM["AUTISM"]
    style REELIN fill:#1a2a3a,stroke:#4fc3f7,stroke-width:1px,color:#e0e0e0
    ALS["ALS"] -->|"associated"| AUTISM["AUTISM"]
    style ALS fill:#1a2a3a,stroke:#4fc3f7,stroke-width:1px,color:#e0e0e0
    ALZHEIMER["ALZHEIMER"] -->|"co discussed"| AUTISM["AUTISM"]
    style ALZHEIMER fill:#1a2a3a,stroke:#ef5350,stroke-width:1px,color:#e0e0e0
    style AUTISM fill:#ef5350,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0,font-weight:bold

Outgoing (381)

Target	Relation	Type	Str
BDNF	expressed_in	gene	0.65
WNT	expressed_in	gene	0.65
LEWY BODY	regulates	disease	0.65
TRAUMATIC BRAIN INJURY	associated_with	disease	0.65
LEWY BODY DISEASE	regulates	disease	0.65
INTERNEURON	expressed_in	cell_type	0.65
NEURON	expressed_in	cell_type	0.65
NEURONS	expressed_in	cell_type	0.65
TAU	protects_against	gene	0.65
TAU	promotes	gene	0.65
NEURONS	associated_with	cell_type	0.65
SIRT1	activates	gene	0.65
MICROGLIA	causes	cell_type	0.60
DEPRESSION	interacts_with	entity	0.60
EPILEPSY	interacts_with	entity	0.60
LISSENCEPHALY	interacts_with	entity	0.60
SCHIZOPHRENIA	interacts_with	entity	0.60
DEPRESSION	mediates	entity	0.60
EPILEPSY	mediates	entity	0.60
LISSENCEPHALY	mediates	entity	0.60
REELIN	mediates	entity	0.60
SCHIZOPHRENIA	mediates	entity	0.60
DEPRESSION	upregulates	entity	0.60
SCHIZOPHRENIA	upregulates	entity	0.60
DEPRESSION	causes	entity	0.60
SCHIZOPHRENIA	associated_with	entity	0.60
EPILEPSY	inhibits	entity	0.60
HAND	inhibits	entity	0.60
MTOR	inhibits	entity	0.60
NEURODEGENERATION	inhibits	entity	0.60
SCHIZOPHRENIA	inhibits	entity	0.60
CNTNAP4	associated_with	entity	0.60
DEPRESSION	associated_with	entity	0.60
EPILEPSY	associated_with	entity	0.60
MSA	associated_with	entity	0.60
NEURODEGENERATION	associated_with	entity	0.60
EPILEPSY	regulates	entity	0.60
INTERNEURON	contributes_to	cell_type	0.60
INTERNEURONS	contributes_to	cell_type	0.60
NEURONS	contributes_to	cell_type	0.60
T CELL	regulates	cell_type	0.60
T CELLS	regulates	cell_type	0.60
MAPK	promotes	gene	0.60
GBA	associated_with	gene	0.60
TUMOR	contributes_to	disease	0.60
EPILEPSY	causes	disease	0.60
SYN1	causes	gene	0.60
INTERNEURONS	depleted_in	cell_type	0.55
lissencephaly	interacts_with	disease	0.50
REELIN	interacts_with	protein	0.50

Incoming (558)

Source	Relation	Type	Str
RELN	implicated_in	entity	0.85
REELIN	implicated_in	protein	0.80
ALZHEIMER'S DISEASE	interacts_with	disease	0.75
TAU	treats	protein	0.65
TAU	targets	protein	0.65
MELATONIN	treats	drug	0.65
MELATONIN	activates	drug	0.65
NEURONS	causes	cell_type	0.65
NEURON	degrades	cell_type	0.65
ALZHEIMER'S	associated_with	disease	0.60
REELIN	interacts_with	entity	0.60
ALS	associated_with	entity	0.60
BDNF	expression	gene	0.60
NLGN1	expression	gene	0.60
CACNA1G	regulates	gene	0.60
PVALB	associated_with	gene	0.60
CLOCK	associated_with	gene	0.60
CLOCK	has_variant	gene	0.60
MTNR1A	associated_with	gene	0.60
MTNR1B	associated_with	gene	0.60
SST	inhibits	gene	0.60
SST	associated_with	gene	0.60
NLRP3	inhibits	gene	0.60
BMAL1	inhibits	gene	0.60
CLOCK	inhibits	gene	0.60
CORTEX	implicated_in	brain_region	0.55
NEURON	implicated_in	cell_type	0.55
HIPPOCAMPUS	implicated_in	brain_region	0.55
MELATONIN	associated_with	drug	0.50
ALZHEIMER'S DISEASE	implicated_in	disease	0.45
ANTERIOR CINGULATE	associated_with	brain_region	0.45
NLRP3 INFLAMMASOME	associated_with	pathway	0.45
CHOROID PLEXUS	associated_with	brain_region	0.45
ALZHEIMER	co_discussed	disease	0.40
ALZHEIMER'S	co_discussed	disease	0.40
ALZHEIMER'S DISEASE	co_discussed	disease	0.40
ANXIETY	co_discussed	disease	0.40
ALS	co_discussed	disease	0.40
AMYOTROPHIC LATERAL SCLEROSIS	co_discussed	disease	0.40
ASTROCYTES	regulates	cell_type	0.35
ASTROCYTES	inhibits	cell_type	0.35
AGING	interacts_with	process	0.30

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (1)

Scientific analyses that reference this entity

How does SYNGAP1, a 'synaptic' protein, function in pre-synaptic radial glia cel

neurodevelopment | 2026-04-15 | 1 hypotheses Top: 0.576

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

AUTISM

Understanding Entity Pages

Wiki Pages (20)

AAV Gene Therapy for Neurodevelopmental Epilepsy — Competitive Landscape & Delivery Alternatives

GRIA3 Gene

Microglial Cells — Cell Type Hierarchy

CNTN5 — Contactin 5

Autophagy Mechanisms

ncam2

CNTN6 — Contactin 6

CNTN4 — Contactin 4

Sulforaphane and Nrf2 Activation for Neuroprotection

nf1-protein

CNTN3 — Contactin 3

ZDHHC13 — Zinc Finger DHHC-Type Containing 13

MACF1 — Microtubule-actin crosslinking factor 1

Angelman Syndrome

NPAS3 Gene

Synaptic Dysfunction in Neurodegeneration

Kv7.3 Potassium Channel

DDX3X Gene

Peroxisomal Dysfunction