Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about LYSOSOMES: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
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| Name | LYSOSOMES |
| Key Genes/Proteins | C9ORF72 |
Knowledge base pages for this entity
graph TD
LYSOSOMES["LYSOSOMES"]
LYSOSOMES -->|"regulates"| Autophagy["Autophagy"]
LYSOSOMES -->|"involved_in"| Endocytosis["Endocytosis"]
LYSOSOMES -->|"involved_in"| Lysosomal_Storage_Disorders["Lysosomal Storage Disorders"]
LYSOSOMES -->|"causes"| Lysosomal_Storage_Diseases["Lysosomal Storage Diseases"]
LYSOSOMES -->|"causes"| Neurodegeneration["Neurodegeneration"]
LYSOSOMES -->|"involved_in"| Amyloid_Beta["Amyloid Beta"]
LYSOSOMES -->|"involved_in"| Nutrient_Sensing["Nutrient Sensing"]
TMEM192["TMEM192"] -->|"expressed in"| LYSOSOMES
Autophagy -->|"involved_in"| LYSOSOMES
Endocytosis -->|"involved_in"| LYSOSOMES
Lysosome_Quality_Control["Lysosome Quality Control"] -->|"regulates"| LYSOSOMES
Autophagosomes["Autophagosomes"] -->|"interacts"| LYSOSOMES
Phosphatidylinositol_3_Phospha["Phosphatidylinositol 3-Phosphate"] -->|"regulates"| LYSOSOMES
Lysosome_Membrane_Protein_Regu["Lysosome Membrane Protein Regulation"] -->|"regulates"| LYSOSOMES
Lysosome_Membrane_Protein_Degr["Lysosome Membrane Protein Degradation"] -->|"involved_in"| LYSOSOMES| Target | Relation | Type | Str |
|---|---|---|---|
| Autophagy | regulates | process | 0.95 |
| Endocytosis | involved_in | process | 0.95 |
| Autophagy | involved_in | process | 0.95 |
| Lysosomal Storage Disorders | involved_in | disease | 0.90 |
| Hematoma clearance | involved_in | process | 0.90 |
| Lysosomal Storage Diseases | causes | disease | 0.90 |
| Neurodegeneration | causes | disease | 0.90 |
| Neurodegeneration | involved_in | disease | 0.90 |
| Cancer | involved_in | disease | 0.90 |
| Autophagy | mediates | process | 0.90 |
| Parkinson'S Disease | involved_in | disease | 0.88 |
| Nutrient Sensing | involved_in | process | 0.85 |
| Phagosome | interacts_with | cell_type | 0.85 |
| Signal Transduction | involved_in | process | 0.85 |
| Amyloid Beta | involved_in | protein | 0.85 |
| Neurodegeneration | associated_with | process | 0.85 |
| Ferroptosis | regulates | process | 0.85 |
| Cancer | associated_with | disease | 0.80 |
| DAT | degrades | protein | 0.80 |
| autophagy | regulates | process | 0.70 |
| Source | Relation | Type | Str |
|---|---|---|---|
| C9ORF72 | regulates | gene | 0.64 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| No targeting hypotheses | |||
Scientific analyses that reference this entity
No analyses mention this entity
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||