protein

LAMP1

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about LAMP1: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

1477Connections

1Hypotheses

6Analyses

50Outgoing

50Incoming

Summary

Detailed page for LAMP1 Protein, a major lysosomal membrane glycoprotein involved in autophagy and neurodegenerative diseases

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🔬 Protein Info

Gene Symbol	LAMP1
Full Name	Lysosomal Associated Membrane Protein 1
Chromosome	13q34
Protein Family	LAMP family
Protein Type	Structural Protein
Target Class	Structural Protein
Function	Protects lysosomal membrane proteins from proteolytic degradation
Mechanism of Action	Direct LAMP1 modulators enhance lysosomal membrane trafficking and autophagy flux, while indirect pathway drugs alter lysosomal pH and autophagosome-lysosome fusion dynamics to modulate LAMP1-mediated cellular clearance mechanisms.
Primary Expression	Ubiquitous, highest in brain
Druggability	Low (0.43)
Clinical Stage	Phase I
Molecular Weight	120 kDa
Amino Acids	417 aa
Pathways	mTOR
UniProt ID	P11279
GeneCards	LAMP1
Human Protein Atlas	LAMP1
Associated Diseases	AD, ADH, ALS, AMI, Alzheimer
Known Drugs/Compounds	RAPAMYCIN, COENZYME Q10, rapamycin
Interactions	ATG7, JUN, CALCINEURIN, ATG12, ATG10, ACTB
SciDEX Target	View Target Profile (8 clinical trials)
SciDEX Hypotheses	Lysosomal Positioning Dynamics Modulation
KG Connections	1477 knowledge graph edges
Databases	GeneCards NCBI Gene HPA STRING

🧬 3D Structure: LAMP1 — PDB 5GV0 Click to expand

Experimental structure from RCSB PDB | Powered by Mol*

Wiki Pages (21)

Knowledge base pages for this entity

Canonical Page

Pathway Diagram

flowchart TD
    LAMP1(["LAMP1"])
    TMEM175(["TMEM175"])
    Lysosomal_pH_Homeostasis("Lysosomal pH Homeostasis")
    h_b295a9dd["h-b295a9dd"]
    SQSTM1(["SQSTM1"])
    Lysosomal_Acidification("Lysosomal Acidification")
    Lysosomal_Degradation("Lysosomal Degradation")
    SLAMF7(["SLAMF7"])
    Autophagy["Autophagy"]
    AUTOPHAGY(["AUTOPHAGY"])
    Parkinson["Parkinson"]
    Als["Als"]
    Tumor["Tumor"]

    LAMP1 -->|"interacts with"| TMEM175
    LAMP1 -.->|"inhibits"| TMEM175
    LAMP1 -->|"regulates"| Lysosomal_pH_Homeostasis
    h_b295a9dd -->|"therapeutic target"| LAMP1
    SQSTM1 -->|"co-localizes"| LAMP1
    h_b295a9dd -->|"targets gene"| LAMP1
    LAMP1 -->|"associated with"| Lysosomal_Acidification
    LAMP1 -->|"involved in"| Lysosomal_Degradation
    SLAMF7 -->|"activates"| LAMP1
    h_b295a9dd -->|"targets"| LAMP1
    LAMP1 -->|"activates"| Autophagy
    LAMP1 -->|"associated with"| AUTOPHAGY
    LAMP1 -->|"associated with"| Parkinson
    LAMP1 -->|"activates"| Als
    LAMP1 -->|"associated with"| Tumor

    style LAMP1 fill:#006494,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0

Outgoing (873)

Target	Relation	Type	Str
TMEM175	interacts_with	protein	0.95
TMEM175	inhibits	protein	0.95
Lysosome Biogenesis	involved_in	process	0.95
Lysosomal Ph Homeostasis	regulates	process	0.95
Lysosomes	component_of	organelle	0.95
Autophagy	involved_in	process	0.95
RAPAMYCIN	activates	drug	0.95
Lysosomal pH Homeostasis	regulates	process	0.90
Lysosomal Acidification	promotes	process	0.90
neural stem cells	activates	cell_type	0.90
Lysosomal Acidification	associated_with	process	0.85
lysosomal hydrolytic function	promotes	process	0.85
Parkinson'S Disease	involved_in	disease	0.85
Parkinson'S Disease	risk_factor_for	disease	0.85
MCOLN1	co_mentioned_with	gene	0.80
lysosomal membrane integrity	associated_with	process	0.80
Lysosomal Degradation	involved_in	process	0.80
RNA	activates	gene	0.80
oxidative stress response	participates_in	pathway	0.80
neural stem cells	regulates	cell_type	0.80
Autophagy	activates	pathway	0.80
AUTOPHAGY	associated_with	gene	0.80
Parkinson	associated_with	disease	0.75
Als	activates	disease	0.75
Tumor	associated_with	disease	0.75
Neurodegeneration	associated_with	disease	0.75
Als	regulates	disease	0.75
Parkinson's Disease	associated_with	disease	0.75
Inflammation	associated_with	disease	0.75
microglia	expressed_in	cell_type	0.75
MTOR	associated_with	gene	0.70
MAP1LC3B	associated_with	gene	0.70
P62	associated_with	gene	0.70
PYCARD	associated_with	gene	0.70
TNF	associated_with	gene	0.70
STX17	associated_with	gene	0.70
CASP1	associated_with	gene	0.70
P62	activates	gene	0.70
LC3	regulates	gene	0.70
TAU	phosphorylates	protein	0.70
adenosine	activates	neurotransmitter	0.70
LAMP2	co_expressed_with	gene	0.70
lysosomal acidification	regulates	process	0.70
lysosomal degradation	regulates	process	0.70
Autophagy	regulates	pathway	0.70
Autophagy	associated_with	pathway	0.70
AUTOPHAGY	regulates	gene	0.70
Autophagy	expressed_in	pathway	0.70
IMMUNE INFILTRATION	associated_with	gene	0.70
AUTOPHAGY	activates	gene	0.70

Incoming (604)

Source	Relation	Type	Str
SQSTM1	co-localizes	gene	0.90
rapamycin	targets	drug	0.90
h-b295a9dd	targets_gene	hypothesis	0.90
SLAMF7	activates	gene	0.80
h-b295a9dd	targets	hypothesis	0.80
ATG	activates	gene	0.80
SQSTM1	associated_with	gene	0.70
CTSB	associated_with	gene	0.70
BECN1	associated_with	gene	0.70
VAMP8	associated_with	gene	0.70
ULK1	associated_with	gene	0.70
LC3	associated_with	gene	0.70
ACTB	activates	gene	0.70
ASC	associated_with	gene	0.70
NLRP3	associated_with	gene	0.70
AIM2	associated_with	gene	0.70
SQSTM1	activates	gene	0.70
SQSTM1	expressed_in	gene	0.70
AR	activates	gene	0.70
TFEB	causes	gene	0.70
CTSB	interacts_with	gene	0.70
ATG16L1	activates	gene	0.70
GENES	associated_with	gene	0.70
LC3B	activates	gene	0.70
PARKINSON	associated_with	gene	0.70
LYSOSOME	regulates	gene	0.70
AUTOPHAGY	activates	gene	0.70
INFLAMMATION	associated_with	gene	0.70
AKT	associated_with	gene	0.65
ATG7	associated_with	gene	0.65
APP	associated_with	gene	0.65
BCL2	inhibits	gene	0.65
TFEB	mediates	gene	0.65
AMYLOID	associated_with	gene	0.65
ALZHEIMER	associated_with	gene	0.65
ASTROCYTE	associated_with	gene	0.65
CANCER	regulates	disease	0.65
GLUTAMATE	activates	phenotype	0.65
ASTROCYTES	phosphorylates	cell_type	0.65
ACTB	regulates	gene	0.60
PPARA	regulates	gene	0.60
CAT	regulates	gene	0.60
SQSTM1	regulates	gene	0.60
RPS6KB1	regulates	gene	0.60
RAB7A	regulates	gene	0.60
SREBF1	regulates	gene	0.60
EIF4EBP1	regulates	gene	0.60
CTSD	regulates	gene	0.60
PPARGC1A	regulates	gene	0.60
LRP2	regulates	gene	0.60

Targeting Hypotheses (1)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
Lysosomal Positioning Dynamics Modulation	0.430	neurodegeneration	Autophagy-lysosome pathway convergence a

Mentioning Analyses (6)

Scientific analyses that reference this entity

Epigenetic reprogramming in aging neurons

neurodegeneration | 2026-04-04 | 9 hypotheses Top: 0.670

Tau propagation mechanisms and therapeutic interception points

neurodegeneration | 2026-04-04 | 7 hypotheses Top: 0.487

Gene expression changes in aging mouse brain predicting neurodegenerative vulner

neurodegeneration | 2026-04-03 | 34 hypotheses Top: 0.692

Tau propagation mechanisms and therapeutic interception points

neurodegeneration | 2026-04-03 | 1 hypotheses Top: 0.512

Autophagy-lysosome pathway convergence across neurodegenerative diseases

neurodegeneration | 2026-04-01 | 7 hypotheses Top: 0.665

Related Papers (20)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
Alpha-synuclein, autophagy-lysosomal pathway, and Lewy bodies: Mutations, propag [PMID:39233232]	Bayati A, McPherson PS	J Biol Chem	2024	1
Lysosomal LAMP proteins regulate lysosomal pH by direct inhibition of the TMEM17 [PMID:37390818]	Zhang J, Zeng W, Han Y, Lee WR, Liou J,	Mol Cell	2023	1
Endosomal-Lysosomal and Autophagy Pathway in Alzheimer's Disease: A Systematic R [PMID:35754279]	Saffire H Krance, Che-Yuan Wu, Alison C	Journal of Alzheimer's disease	2022	1
Ischemia-induced upregulation of autophagy preludes dysfunctional lysosomal stor [PMID:33111641]	Zhang X, Wei M, Fan J, Yan W, Zha X, Son	Autophagy	2021	1
Roles of LAMP-1 and LAMP-2 in lysosome biogenesis and autophagy. [PMID:16973206]	Eskelinen EL	Mol Aspects Med	2006	1
Efficacy of Der f 2/Zen 1-LAMP1 Plasmid-Based Vaccine Immunotherapy in Dogs With [PMID:41287364]	Bizikova P, Matsumoto C, Ogino S, Tsukui	Vet Dermatol	2026	0
Measuring lysosome damage and lysophagy in vivo. [PMID:41485143]	Wu Z, Zhan H, Huang Z, Wang C, Li B et a	Autophagy	2026	0
Metabolites released from apoptotic cells in central nervous system orchestrates [PMID:41518198]	Xiao F, Tan X, He A, Zhou Y, Xu K et al.	Autophagy	2026	0
Preparation of a polyclonal antibody against Lysosome-Associated Membrane Protei [PMID:41825675]	Luo J, Shi Y, Jiang X, Zhang B, Chen Y e	Int J Biol Macromol	2026	0
Increased Glycogenin-Exposed Residual Glycogen in Lysosomes Is the Early Patholo [PMID:41923452]	Shi Y, Zhang N, Sun H, Wang Y, Zhao D et	Muscle Nerve	2026	0
Wild-type and pathogenic forms of ubiquilin 2 differentially modulate components [PMID:37257946]	Idera A, Sharkey LM, Kurauchi Y, Kadoyam	Journal of pharmacological sci	2023	0
Lamp1 mediates lipid transport, but is dispensable for autophagy in Drosophila. [PMID:35266854]	Chaudhry N, Sica M, Surabhi S, Hernandez	Autophagy	2022	0
Genetically Encoded, pH-Sensitive mTFP1 Biosensor for Probing Lysosomal pH. [PMID:34102054]	Chin MY, Patwardhan AR, Ang KH, Wang AL,	ACS sensors	2021	0
ATP13A2 facilitates HDAC6 recruitment to lysosome to promote autophagosome-lysos [PMID:30538141]	Wang R, Tan J, Chen T, Han H, Tian R, Ta	The Journal of cell biology	2019	0
CD107a Degranulation Assay to Evaluate Immune Cell Antitumor Activity. [PMID:30465198]	Lorenzo-Herrero S, Sordo-Bahamonde C, Go	Methods in molecular biology (	2019	0
Circumventing kinetics in biogeochemical modeling. [PMID:31097587]	["Louca S", "Scranton M", "Taylor G", "A	Proceedings of the National Ac	2019	0
Revisiting LAMP1 as a marker for degradative autophagy-lysosomal organelles in t [PMID:29940787]	Cheng XT, Xie YX, Zhou B, Huang N, Farfe	Autophagy	2018	0
NUP98 is rearranged in 3.8% of pediatric AML forming a clinical and molecular ho [PMID:27694926]	["Struski S", "Lagarde S", "Bories P", "	Leukemia	2017	0
Comprehensive Analysis of Hypermutation in Human Cancer. [PMID:29056344]	["Campbell B", "Light N", "Fabrizio D",	Cell	2017	0
A model of synaptic vesicle-pool depletion and replenishment can account for the [PMID:25378173]	["Peterson A", "Irvine D", "Heil P"]	The Journal of neuroscience :	2014	0

LAMP1

Understanding Entity Pages

Summary

Wiki Pages (21)

Lysosomal Associated Membrane Protein 1 (LAMP1)

cbs-psp-daily-action-plan

Autophagy Mechanisms

rapamycin-tauopathy

Lysosomal Dysfunction in Neurodegeneration

autophagy-lysosomal-alzheimers

DNAJC13 — DnaJ Heat Shock Protein Family Member C13

Tunneling Nanotubes in Neurodegeneration

Granulovacuolar Bodies: Neuronal Defense Mechanism Against Tau Pathology

lmx1b

Autophagy-Lysosomal Pathway in Parkinson's Disease

Microglia Activation Mechanism

autophagy-lysosome-dysfunction

Endolysosomal Trafficking Defects in Neurodegeneration

Section 189: Advanced Autophagy-Endolysosomal Pathway Therapy in CBS/PSP

MAP1LC3A Gene

TMEM175 Protein

VPS35 Retromer Stabilizer for Lysosomal Rescue

Metabolic-Energetic Restoration: GLP-1 + TFEB Activator Combination

VPS35 — Vacuolar Protein Sorting 35 Homolog

Section 188: Advanced Lipidomics and Membrane Therapy in CBS/PSP

Pathway Diagram

Outgoing (873)

Incoming (604)

Targeting Hypotheses (1)

Mentioning Analyses (6)

Epigenetic reprogramming in aging neurons

Tau propagation mechanisms and therapeutic interception points

Gene expression changes in aging mouse brain predicting neurodegenerative vulner

Tau propagation mechanisms and therapeutic interception points

Autophagy-lysosome pathway convergence across neurodegenerative diseases

What are the mechanisms by which gut microbiome dysbiosis influences Parkinson's

Related Papers (20)