Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about METALLOTHIONEINS: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
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| Gene Symbol | METALLOTHIONEINS |
| Protein Type | Protein |
| Function | Metallothioneins (MTs) are a family of small, cysteine-rich that play crucial roles in metal homeostasis, antioxidant defense, and neuroprotection in the central nervous system |
| Primary Expression | astrocytes - Highly inducible by cytokines, metals, and oxidative stress - Critical for metal detoxification and astrocyte-neuron communication - Upre |
| Amino Acids | 68 aa |
| UniProt ID | Search UniProt |
| GeneCards | METALLOTHIONEINS |
| Human Protein Atlas | METALLOTHIONEINS |
| Cysteine-rich composition | 20 conserved cysteine residues (30% of total amino acids) |
| Metal-thiolate clusters | Zn(II)-thiolate clusters (Zn₇MT) that serve as zinc buffers |
| Metal-binding versatility | Can bind Zn²⁺, Cu⁺, Cd²⁺, Hg²⁺, and Fe²⁺ |
| Reduced domain organization | Two domains (β and α) with distinct metal-binding properties |
| Associated Diseases | ALS, Huntington, Neurodegeneration |
| KG Connections | 15 knowledge graph edges |
| Databases | GeneCardsNCBI GeneHPASTRING |
Knowledge base pages for this entity
graph TD
METALLOTHIONEINS["METALLOTHIONEINS"]
METALLOTHIONEINS -->|"expressed in"| Astrocyte["Astrocyte"]
METALLOTHIONEINS -->|"expressed in"| Neuron["Neuron"]
METALLOTHIONEINS -->|"implicated in"| neurodegeneration["neurodegeneration"]
METALLOTHIONEINS ---|"associated"| Neurodegeneration["Neurodegeneration"]
METALLOTHIONEINS ---|"associated"| Huntington["Huntington"]
METALLOTHIONEINS ---|"associated"| ALS["ALS"]
METALLOTHIONEINS ---|"associated"| HUNTINGTON_S_DISEASE["HUNTINGTON'S DISEASE"]
METALLOTHIONEINS ---|"associated"| HUNTINGTON["HUNTINGTON"]
NEURODEGENERATION["NEURODEGENERATION"] ---|"associated"| METALLOTHIONEINS
GENES["GENES"] ---|"associated"| METALLOTHIONEINS
CD44["CD44"] ---|"associated"| METALLOTHIONEINS
ASTROCYTE["ASTROCYTE"] ---|"associated"| METALLOTHIONEINS
HTT["HTT"] ---|"associated"| METALLOTHIONEINS| Target | Relation | Type | Str |
|---|---|---|---|
| Huntington | associated_with | disease | 0.65 |
| ALS | associated_with | disease | 0.65 |
| Neurodegeneration | associated_with | disease | 0.65 |
| Lipid Metabolism | associated_with | pathway | 0.60 |
| HUNTINGTON'S DISEASE | associated_with | gene | 0.60 |
| HUNTINGTON | associated_with | gene | 0.60 |
| ASTROCYTES | associated_with | gene | 0.60 |
| Astrocyte | expressed_in | cell_type | 0.55 |
| Neuron | expressed_in | cell_type | 0.55 |
| Astrocyte | associated_with | cell_type | 0.50 |
| Source | Relation | Type | Str |
|---|---|---|---|
| CD44 | associated_with | gene | 0.60 |
| HTT | associated_with | gene | 0.60 |
| NEURODEGENERATION | associated_with | gene | 0.60 |
| GENES | associated_with | gene | 0.60 |
| ASTROCYTE | associated_with | gene | 0.60 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| No targeting hypotheses | |||
Scientific analyses that reference this entity
No analyses mention this entity
Experimental studies targeting or related to this entity
| Experiment | Type | Disease | Score | Feasibility | Model | Status | Est. Cost |
|---|---|---|---|---|---|---|---|
| No experiments found | |||||||
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||
Multi-agent debates referencing this entity
No debates reference this entity
Hypotheses and analyses mentioning METALLOTHIONEINS in their description or question text
No additional research found