gene

CD44

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about CD44: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

795Connections
0Hypotheses
0Analyses
50Outgoing
50Incoming

Summary

CD44 is a gene implicated in neurodegeneration research. Key relationships include: therapeutic target, activates, inhibits. Associated with Aging, Als, Alzheimer. Connected to 358 entities in the SciDEX knowledge graph.

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🧬 Gene Info
Gene SymbolCD44
Full NameCell Surface Glycoprotein
AliasesPage for CD44
Chromosome11p13
Protein TypeReceptor
Functionis an important component in the neurobiology of neurodegenerative diseases.
Molecular Weight95 kDa
Amino Acids341 aa
Exons19
PathwaysNF-κB, TGF-β
NCBI Gene ID2115452
Ensembl IDENSG00000026508
GeneCardsCD44
Human Protein AtlasCD44
Associated DiseasesALS, Aging, Alzheimer, Cardiac, Fibrosis
InteractionsSOX2, EGFR, C1Q, SMAD4, GFAP, HMOX1
KG Connections795 knowledge graph edges
DatabasesGeneCardsUniProtHPASTRING

Wiki Pages (21)

Knowledge base pages for this entity

Canonical Page

CD44 - Cell Surface Glycoprotein

gene · 1313 words

Astrocytes

cell · 3974 words

TGF-β Signaling in Parkinson's Disease

mechanism · 3514 words

Gamma-Secretase Complex (γ-Secretase)

protein · 3346 words

MYT1L Gene

gene · 3099 words

Ibudilast

therapeutic · 2773 words

Pathway Diagram

graph TD
    CD44["CD44"]
    CD44 -->|"inhibits"| Cancer["Cancer"]
    CD44 -->|"inhibits"| Tumor["Tumor"]
    CD44 -->|"target for"| Fibrosis["Fibrosis"]
    CD44 -->|"target for"| Hepatitis["Hepatitis"]
    CD44 -->|"target for"| Carcinoma["Carcinoma"]
    CD44 -->|"target for"| Als["Als"]
    CD44 -->|"target for"| Inflammation["Inflammation"]
    FGF20["FGF20"] -->|"target for"| CD44
    BRG1["BRG1"] -->|"target for"| CD44
    NRCAM["NRCAM"] -->|"target for"| CD44
    NOTCH2["NOTCH2"] -->|"target for"| CD44
    EP300["EP300"] -->|"target for"| CD44
    CTNNB1["CTNNB1"] -->|"target for"| CD44
    NEUROD1["NEUROD1"] -->|"target for"| CD44
    MYC["MYC"] -->|"target for"| CD44

Outgoing (616)

TargetRelationTypeStr
Cancertherapeutic_targetdisease1.00
CANCERtherapeutic_targetgene1.00
Tumortherapeutic_targetdisease0.95
ERKactivatesprotein0.88
Tumorinhibitsdisease0.85

Incoming (179)

SourceRelationTypeStr
SPP1binds_toprotein0.93
AKTregulatesprotein0.85
INFLAMMATIONtherapeutic_targetgene0.70
FGF20therapeutic_targetgene0.60
BRG1therapeutic_targetgene0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

HypothesisScoreDiseaseAnalysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMIDAuthorsJournalYearCitations
No papers found