gene

CD44

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about CD44: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

748Connections

4Hypotheses

1Analyses

50Outgoing

50Incoming

0Experiments

1Debates

Summary

CD44 is a gene implicated in neurodegeneration research. Key relationships include: therapeutic target, activates, inhibits. Associated with Aging, Als, Alzheimer. Connected to 358 entities in the SciDEX knowledge graph.

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🧬 Gene Info

Gene Symbol	CD44
Full Name	Cell Surface Glycoprotein
Aliases	Page for CD44
Chromosome	11p13
Protein Type	Receptor
Function	is an important component in the neurobiology of neurodegenerative diseases.
Molecular Weight	95 kDa
Amino Acids	341 aa
Exons	19
Pathways	NF-κB, TGF-β
NCBI Gene ID	2115452
Ensembl ID	ENSG00000026508
GeneCards	CD44
Human Protein Atlas	CD44
Associated Diseases	Aging, Als, Alzheimer, Cardiac, dementia
Interactions	ADAM10, AKT, ALS, ALZHEIMER, ALZHEIMER DISEASE, ALZHEIMER'S DISEASE
SciDEX Hypotheses	CD44-SPP1 Axis Precision Targeting Hyaluronidase Treatment Disrupts Perivascular Infl
KG Connections	747 knowledge graph edges
Databases	GeneCards UniProt HPA STRING

Wiki Pages (2)

Knowledge base pages for this entity

Canonical Page

CD44 - Cell Surface Glycoprotein

gene · 1313 words

→

CD44 Protein

protein · 1350 words

→

Pathway Diagram

graph TD
    CD44["CD44"]
    CD44 -->|"inhibits"| Cancer["Cancer"]
    CD44 -->|"inhibits"| Tumor["Tumor"]
    CD44 -->|"target for"| Fibrosis["Fibrosis"]
    CD44 -->|"target for"| Hepatitis["Hepatitis"]
    CD44 -->|"target for"| Carcinoma["Carcinoma"]
    CD44 -->|"target for"| Als["Als"]
    CD44 -->|"target for"| Inflammation["Inflammation"]
    FGF20["FGF20"] -->|"target for"| CD44
    BRG1["BRG1"] -->|"target for"| CD44
    NRCAM["NRCAM"] -->|"target for"| CD44
    NOTCH2["NOTCH2"] -->|"target for"| CD44
    EP300["EP300"] -->|"target for"| CD44
    CTNNB1["CTNNB1"] -->|"target for"| CD44
    NEUROD1["NEUROD1"] -->|"target for"| CD44
    MYC["MYC"] -->|"target for"| CD44

Outgoing (574)

Target	Relation	Type	Str
CD44	encodes	protein	0.00
CANCER	therapeutic_target	gene	1.00
Cancer	therapeutic_target	disease	1.00
Tumor	therapeutic_target	disease	0.95
ERK	activates	protein	0.88
MICROGLIA	upregulates	cell_type	0.85
Tumor	inhibits	disease	0.85
Als	therapeutic_target	disease	0.85
microglia	upregulates	cell_type	0.80
microglia migration	promotes	process	0.80
Fibrosis	therapeutic_target	disease	0.75
Pancreatic Cancer	therapeutic_target	disease	0.75
Als	associated_with	disease	0.75
Als	activates	disease	0.75
Cancer	activates	disease	0.75
Inflammation	therapeutic_target	disease	0.75
Carcinoma	activates	disease	0.75
Cancer	inhibits	disease	0.75
Lung Cancer	therapeutic_target	disease	0.75
Notch	therapeutic_target	pathway	0.70
Mapk	inhibits	pathway	0.70
SOX2	inhibits	gene	0.70
MYC	targets	gene	0.70
phagocytic_activation	regulates	process	0.70
lipid metabolism	participates_in	pathway	0.70
CANCER	activates	gene	0.70
HIF	therapeutic_target	gene	0.70
Glycolysis	therapeutic_target	pathway	0.70
CANCER	inhibits	gene	0.70
ABCB1	therapeutic_target	gene	0.70
Hepatocellular Carcinoma	therapeutic_target	disease	0.65
Infection	therapeutic_target	disease	0.65
Colorectal Cancer	therapeutic_target	disease	0.65
Alzheimer	interacts_with	disease	0.65
Ms	expressed_in	disease	0.65
Prostate Cancer	therapeutic_target	disease	0.65
Liver Cancer	therapeutic_target	disease	0.65
Cancer	expressed_in	disease	0.65
Glioblastoma	associated_with	disease	0.65
Glioblastoma	expressed_in	disease	0.65
Tumor	activates	disease	0.65
Heart Failure	expressed_in	disease	0.65
Pulmonary Fibrosis	therapeutic_target	disease	0.65
Lymphoma	associated_with	disease	0.65
Ischemia	activates	disease	0.65
Leukemia	associated_with	disease	0.65
Inflammation	activates	disease	0.65
Traumatic Brain Injury	activates	disease	0.65
Tumor	expressed_in	disease	0.65
Stroke	activates	disease	0.65

Incoming (174)

Source	Relation	Type	Str
CD44	encodes	gene	0.00
SPP1	binds_to	protein	0.93
AKT	regulates	protein	0.85
MYC	enhances	gene	0.70
INFLAMMATION	therapeutic_target	gene	0.70
CTNNB1	therapeutic_target	gene	0.60
EP300	therapeutic_target	gene	0.60
BRG1	therapeutic_target	gene	0.60
FOXM1	therapeutic_target	gene	0.60
VEGFA	therapeutic_target	gene	0.60
SMARCA4	therapeutic_target	gene	0.60
TERT	therapeutic_target	gene	0.60
FZD7	therapeutic_target	gene	0.60
JAG1	therapeutic_target	gene	0.60
NOTCH2	therapeutic_target	gene	0.60
PIK3CA	regulates	gene	0.60
CD4	regulates	gene	0.60
MYC	therapeutic_target	gene	0.60
CLDN1	therapeutic_target	gene	0.60
AXIN1	therapeutic_target	gene	0.60
ANXA2	activates	gene	0.60
ICAM1	activates	gene	0.60
CDKN2A	inhibits	gene	0.60
TLR4	inhibits	gene	0.60
TNC	inhibits	gene	0.60
NTRK2	inhibits	gene	0.60
PAK1	inhibits	gene	0.60
WNT7A	inhibits	gene	0.60
LZTS1	inhibits	gene	0.60
DCC	inhibits	gene	0.60
IL10	therapeutic_target	gene	0.60
FGF18	therapeutic_target	gene	0.60
GAIN	therapeutic_target	gene	0.60
CREBBP	therapeutic_target	gene	0.60
PPARD	therapeutic_target	gene	0.60
APC	therapeutic_target	gene	0.60
DKK1	therapeutic_target	gene	0.60
TLR4	therapeutic_target	gene	0.60
P2RY12	inhibits	gene	0.60
STAT3	inhibits	gene	0.60
BAX	inhibits	gene	0.60
PINK1	inhibits	gene	0.60
GSDME	activates	gene	0.60
MMP9	inhibits	gene	0.60
HTT	associated_with	gene	0.60
CASPASE3	activates	gene	0.60
ACTB	associated_with	gene	0.60
GAPDH	associated_with	gene	0.60
GAPDH	therapeutic_target	gene	0.60
KCNK2	inhibits	gene	0.60

Targeting Hypotheses (4)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
Hypothesis 2: GPNMB-CD44 Axis as Anti-inflammatory Pathway	0.772	neurodegeneration	Which specific factors in conditioned me
CD44-Mediated Src/PI3K/Akt Signaling Cascade	0.470	neuroinflammation	What molecular mechanisms mediate SPP1-i
CD44-SPP1 Axis Precision Targeting	0.000	-	What molecular mechanisms mediate SPP1-i
Hyaluronidase Treatment Disrupts Perivascular Inflammatory N	0.000	-	Microglia-astrocyte crosstalk amplificat

Mentioning Analyses (1)

Scientific analyses that reference this entity

What molecular mechanisms mediate SPP1-induced microglial phagocytic activation

neuroinflammation | 2026-04-15 | 13 hypotheses Top: 0.752

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (6)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year
The temporal and stimuli-specific effects of LPS and IFNγ on microglial activati [PMID:41695273]	Heiss CN, Naylor AS, Pesämaa I, Meshi A,	Front Aging Neurosci	2026
CD44 connects autophagy decline and ageing in the vascular endothelium. [PMID:37684253]	Unknown	Nat Commun	2023
The membrane receptor CD44: novel insights into metabolism. [PMID:35249813]	Unknown	Trends Endocrinol Metab	2022
CD44: A Multifunctional Mediator of Cancer Progression. [PMID:34944493]	Unknown	Biomolecules	2021
The glycoprotein GPNMB attenuates astrocyte inflammatory responses through the C [PMID:29519253]	["Matthew L Neal", "Alexa M Boyle", "Kev	Journal of neuroinflammation	2019
HAS2 and CD44 in breast tumorigenesis. [PMID:25081531]	Unknown	Adv Cancer Res	2014

Debates (1)

Multi-agent debates referencing this entity

What molecular mechanisms mediate SPP1-induced microglial phagocytic activation

closed · Rounds: 5 · Score: 0.95 · 2026-04-15

Related Research

Hypotheses and analyses mentioning CD44 in their description or question text

No additional research found