Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about CD44: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
CD44 is a gene implicated in neurodegeneration research. Key relationships include: therapeutic target, activates, inhibits. Associated with Aging, Als, Alzheimer. Connected to 358 entities in the SciDEX knowledge graph.
| Gene Symbol | CD44 |
| Full Name | Cell Surface Glycoprotein |
| Aliases | Page for CD44 |
| Chromosome | 11p13 |
| Protein Type | Receptor |
| Function | is an important component in the neurobiology of neurodegenerative diseases. |
| Molecular Weight | 95 kDa |
| Amino Acids | 341 aa |
| Exons | 19 |
| Pathways | NF-κB, TGF-β |
| NCBI Gene ID | 2115452 |
| Ensembl ID | ENSG00000026508 |
| GeneCards | CD44 |
| Human Protein Atlas | CD44 |
| Associated Diseases | ALS, Aging, Alzheimer, Cardiac, Fibrosis |
| Interactions | SOX2, EGFR, C1Q, SMAD4, GFAP, HMOX1 |
| KG Connections | 795 knowledge graph edges |
| Databases | GeneCardsUniProtHPASTRING |
Knowledge base pages for this entity
graph TD
CD44["CD44"]
CD44 -->|"inhibits"| Cancer["Cancer"]
CD44 -->|"inhibits"| Tumor["Tumor"]
CD44 -->|"target for"| Fibrosis["Fibrosis"]
CD44 -->|"target for"| Hepatitis["Hepatitis"]
CD44 -->|"target for"| Carcinoma["Carcinoma"]
CD44 -->|"target for"| Als["Als"]
CD44 -->|"target for"| Inflammation["Inflammation"]
FGF20["FGF20"] -->|"target for"| CD44
BRG1["BRG1"] -->|"target for"| CD44
NRCAM["NRCAM"] -->|"target for"| CD44
NOTCH2["NOTCH2"] -->|"target for"| CD44
EP300["EP300"] -->|"target for"| CD44
CTNNB1["CTNNB1"] -->|"target for"| CD44
NEUROD1["NEUROD1"] -->|"target for"| CD44
MYC["MYC"] -->|"target for"| CD44| Target | Relation | Type | Str |
|---|---|---|---|
| Cancer | therapeutic_target | disease | 1.00 |
| CANCER | therapeutic_target | gene | 1.00 |
| Tumor | therapeutic_target | disease | 0.95 |
| ERK | activates | protein | 0.88 |
| Tumor | inhibits | disease | 0.85 |
| Als | therapeutic_target | disease | 0.85 |
| MICROGLIA | upregulates | cell_type | 0.85 |
| microglia migration | promotes | process | 0.80 |
| microglia | upregulates | cell_type | 0.80 |
| Cancer | inhibits | disease | 0.75 |
| Fibrosis | therapeutic_target | disease | 0.75 |
| Inflammation | therapeutic_target | disease | 0.75 |
| Als | activates | disease | 0.75 |
| Als | associated_with | disease | 0.75 |
| Lung Cancer | therapeutic_target | disease | 0.75 |
| Pancreatic Cancer | therapeutic_target | disease | 0.75 |
| Carcinoma | activates | disease | 0.75 |
| Cancer | activates | disease | 0.75 |
| SOX2 | inhibits | gene | 0.70 |
| MYC | therapeutic_target | gene | 0.70 |
| ABCB1 | therapeutic_target | gene | 0.70 |
| Notch | therapeutic_target | pathway | 0.70 |
| CANCER | inhibits | gene | 0.70 |
| Mapk | inhibits | pathway | 0.70 |
| HIF | therapeutic_target | gene | 0.70 |
| Glycolysis | therapeutic_target | pathway | 0.70 |
| CANCER | activates | gene | 0.70 |
| lipid metabolism | participates_in | pathway | 0.70 |
| Hepatitis | therapeutic_target | disease | 0.65 |
| Carcinoma | therapeutic_target | disease | 0.65 |
| Ms | therapeutic_target | disease | 0.65 |
| Carcinoma | inhibits | disease | 0.65 |
| Ms | inhibits | disease | 0.65 |
| Obesity | therapeutic_target | disease | 0.65 |
| Inflammation | regulates | disease | 0.65 |
| Ms | regulates | disease | 0.65 |
| Als | regulates | disease | 0.65 |
| Amyotrophic Lateral Sclerosis | regulates | disease | 0.65 |
| Ms | activates | disease | 0.65 |
| Traumatic Brain Injury | activates | disease | 0.65 |
| Inflammation | activates | disease | 0.65 |
| Stroke | activates | disease | 0.65 |
| Ischemia | activates | disease | 0.65 |
| Lymphoma | associated_with | disease | 0.65 |
| Leukemia | associated_with | disease | 0.65 |
| Diabetes | biomarker_for | disease | 0.65 |
| Als | biomarker_for | disease | 0.65 |
| Ms | biomarker_for | disease | 0.65 |
| Tumor | expressed_in | disease | 0.65 |
| Glioblastoma | expressed_in | disease | 0.65 |
| Source | Relation | Type | Str |
|---|---|---|---|
| SPP1 | binds_to | protein | 0.93 |
| AKT | regulates | protein | 0.85 |
| INFLAMMATION | therapeutic_target | gene | 0.70 |
| FGF20 | therapeutic_target | gene | 0.60 |
| BRG1 | therapeutic_target | gene | 0.60 |
| NRCAM | therapeutic_target | gene | 0.60 |
| NOTCH2 | therapeutic_target | gene | 0.60 |
| EP300 | therapeutic_target | gene | 0.60 |
| CTNNB1 | therapeutic_target | gene | 0.60 |
| NEUROD1 | therapeutic_target | gene | 0.60 |
| MYC | therapeutic_target | gene | 0.60 |
| VEGFA | therapeutic_target | gene | 0.60 |
| ABCB1 | therapeutic_target | gene | 0.60 |
| FOXM1 | therapeutic_target | gene | 0.60 |
| LEF1 | therapeutic_target | gene | 0.60 |
| SMARCA4 | therapeutic_target | gene | 0.60 |
| TERT | therapeutic_target | gene | 0.60 |
| FZD7 | therapeutic_target | gene | 0.60 |
| JAG1 | therapeutic_target | gene | 0.60 |
| MITF | therapeutic_target | gene | 0.60 |
| GAIN | therapeutic_target | gene | 0.60 |
| AXIN2 | therapeutic_target | gene | 0.60 |
| CD4 | regulates | gene | 0.60 |
| PIK3CA | regulates | gene | 0.60 |
| ALDH1A1 | therapeutic_target | gene | 0.60 |
| CLDN1 | therapeutic_target | gene | 0.60 |
| AXIN1 | therapeutic_target | gene | 0.60 |
| ANXA2 | activates | gene | 0.60 |
| ICAM1 | activates | gene | 0.60 |
| CDKN2A | inhibits | gene | 0.60 |
| TLR4 | inhibits | gene | 0.60 |
| TNC | inhibits | gene | 0.60 |
| NTRK2 | inhibits | gene | 0.60 |
| PAK1 | inhibits | gene | 0.60 |
| WNT7A | inhibits | gene | 0.60 |
| LZTS1 | inhibits | gene | 0.60 |
| DCC | inhibits | gene | 0.60 |
| KCNK2 | inhibits | gene | 0.60 |
| CREBBP | therapeutic_target | gene | 0.60 |
| FGF18 | therapeutic_target | gene | 0.60 |
| IL10 | therapeutic_target | gene | 0.60 |
| PPARD | therapeutic_target | gene | 0.60 |
| APC | therapeutic_target | gene | 0.60 |
| DKK1 | therapeutic_target | gene | 0.60 |
| ATF3 | therapeutic_target | gene | 0.60 |
| TLR4 | therapeutic_target | gene | 0.60 |
| P2RY12 | inhibits | gene | 0.60 |
| STAT3 | inhibits | gene | 0.60 |
| BAX | inhibits | gene | 0.60 |
| PINK1 | inhibits | gene | 0.60 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| No targeting hypotheses | |||
Scientific analyses that reference this entity
No analyses mention this entity
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||