gene

MYO5A

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about MYO5A: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

11Connections
0Hypotheses
0Analyses
11Outgoing
0Incoming

Summary

MYO5A is a gene implicated in neurodegeneration research. Key relationships include: interacts with, implicated in. Associated with Melanoma, Tumor. Connected to 12 entities in the SciDEX knowledge graph.

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🧬 Gene Info
Gene SymbolMYO5A
Full NameMyosin Va
Chromosome15q21.2.
Functionencodes an unconventional myosin motor protein that moves towards the plus end of actin filaments.
Primary Expressiona tissue-specific manner, with highest levels in brain, melanocytes, and platelets
Molecular Weight205 kDa
Amino Acids855 aa
Ensembl IDENSG00000128594
GeneCardsMYO5A
Human Protein AtlasMYO5A
Processive movementCan traverse >1 μm on actin filaments without detachment
Step sizeTakes ~36 nm steps, matching actin filament periodicity
VelocityMoves at ~300-500 nm/s in vitro
DirectionPlus-end directed (towards actin filament barbed ends)
RegulationCalmodulin binding modulates motor activity in response to calcium
Associated Diseasesneurodegeneration
InteractionsNCOA4, CDKN2A, RET, LMNA, KIF5B, OPTN
KG Connections11 knowledge graph edges
DatabasesGeneCardsUniProtNCBI GeneHPASTRING

Wiki Pages (7)

Knowledge base pages for this entity

Canonical Page

MYO5A — Myosin Va

gene · 1340 words

MYO10 and Mitochondrial Transfer in Neurodegeneration

mechanism · 2835 words

MYO5A Protein

protein · 1556 words

MYO5B — Myosin Vb

gene · 1296 words

BMF Gene

gene · 1033 words

Proteins

index · 296 words

Pathway Diagram

graph TD
    MYO5A["MYO5A"]
    Tumor{"Tumor"}
    MYO5A -->|"interacts_with"| Tumor
    Melanoma{"Melanoma"}
    MYO5A -->|"interacts_with"| Melanoma
    NCOA4["NCOA4"]
    MYO5A -->|"interacts_with"| NCOA4
    CDKN2A["CDKN2A"]
    MYO5A -->|"interacts_with"| CDKN2A
    RET["RET"]
    MYO5A -->|"interacts_with"| RET
    LMNA["LMNA"]
    MYO5A -->|"interacts_with"| LMNA
    KIF5B["KIF5B"]
    MYO5A -->|"interacts_with"| KIF5B
    P16["P16"]
    MYO5A -->|"interacts_with"| P16
    DNA["DNA"]
    MYO5A -->|"interacts_with"| DNA
    OPTN["OPTN"]
    MYO5A -->|"interacts_with"| OPTN
    MYC["MYC"]
    MYO5A -->|"interacts_with"| MYC
    neurodegeneration["neurodegeneration"]
    MYO5A -->|"implicated_in"| neurodegeneration

Outgoing (11)

TargetRelationTypeStr
Tumorinteracts_withdisease0.65
Melanomainteracts_withdisease0.65
NCOA4interacts_withgene0.60
CDKN2Ainteracts_withgene0.60
RETinteracts_withgene0.60

Incoming (0)

SourceRelationTypeStr
No incoming edges

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

HypothesisScoreDiseaseAnalysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMIDAuthorsJournalYearCitations
No papers found