Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about MYO5A: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
MYO5A is a gene implicated in neurodegeneration research. Key relationships include: interacts with, implicated in. Associated with Melanoma, Tumor. Connected to 12 entities in the SciDEX knowledge graph.
| Gene Symbol | MYO5A |
| Full Name | Myosin Va |
| Chromosome | 15q21.2. |
| Function | encodes an unconventional myosin motor protein that moves towards the plus end of actin filaments. |
| Primary Expression | a tissue-specific manner, with highest levels in brain, melanocytes, and platelets |
| Molecular Weight | 205 kDa |
| Amino Acids | 855 aa |
| Ensembl ID | ENSG00000128594 |
| GeneCards | MYO5A |
| Human Protein Atlas | MYO5A |
| Processive movement | Can traverse >1 μm on actin filaments without detachment |
| Step size | Takes ~36 nm steps, matching actin filament periodicity |
| Velocity | Moves at ~300-500 nm/s in vitro |
| Direction | Plus-end directed (towards actin filament barbed ends) |
| Regulation | Calmodulin binding modulates motor activity in response to calcium |
| Associated Diseases | neurodegeneration |
| Interactions | NCOA4, CDKN2A, RET, LMNA, KIF5B, OPTN |
| KG Connections | 11 knowledge graph edges |
| Databases | GeneCardsUniProtNCBI GeneHPASTRING |
Knowledge base pages for this entity
graph TD
MYO5A["MYO5A"]
Tumor{"Tumor"}
MYO5A -->|"interacts_with"| Tumor
Melanoma{"Melanoma"}
MYO5A -->|"interacts_with"| Melanoma
NCOA4["NCOA4"]
MYO5A -->|"interacts_with"| NCOA4
CDKN2A["CDKN2A"]
MYO5A -->|"interacts_with"| CDKN2A
RET["RET"]
MYO5A -->|"interacts_with"| RET
LMNA["LMNA"]
MYO5A -->|"interacts_with"| LMNA
KIF5B["KIF5B"]
MYO5A -->|"interacts_with"| KIF5B
P16["P16"]
MYO5A -->|"interacts_with"| P16
DNA["DNA"]
MYO5A -->|"interacts_with"| DNA
OPTN["OPTN"]
MYO5A -->|"interacts_with"| OPTN
MYC["MYC"]
MYO5A -->|"interacts_with"| MYC
neurodegeneration["neurodegeneration"]
MYO5A -->|"implicated_in"| neurodegeneration| Target | Relation | Type | Str |
|---|---|---|---|
| Tumor | interacts_with | disease | 0.65 |
| Melanoma | interacts_with | disease | 0.65 |
| NCOA4 | interacts_with | gene | 0.60 |
| CDKN2A | interacts_with | gene | 0.60 |
| RET | interacts_with | gene | 0.60 |
| LMNA | interacts_with | gene | 0.60 |
| KIF5B | interacts_with | gene | 0.60 |
| OPTN | interacts_with | gene | 0.60 |
| MYC | interacts_with | gene | 0.60 |
| P16 | interacts_with | gene | 0.60 |
| DNA | interacts_with | gene | 0.60 |
| Source | Relation | Type | Str |
|---|---|---|---|
| No incoming edges | |||
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| No targeting hypotheses | |||
Scientific analyses that reference this entity
No analyses mention this entity
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||