gene

P16

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about P16: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

435Connections

1Hypotheses

2Analyses

50Outgoing

50Incoming

No summary available yet. View on Wiki →

🧬 Gene Info

Gene Symbol	P16
Primary Expression	Ca1, Thalamus, Hypothalamus
Pathways	Cell Cycle, Dna Methylation, Angiogenesis, Histone Modification, Epigenetic
GeneCards	P16
Human Protein Atlas	P16
Associated Diseases	ALS, Aging, Alzheimer, Cancer, Epilepsy, Senescence
Interactions	TERT, MTOR, AKT, AGING, P21, LC3
KG Connections	434 knowledge graph edges
Databases	GeneCards UniProt NCBI Gene HPA STRING

Wiki Pages (20)

Knowledge base pages for this entity

Pathway Diagram

graph TD
    P16["<b>P16</b>"]
    Senescence{"Senescence"}
    P16 -->|"activates"| Senescence
    Aging{"Aging"}
    P16 -->|"activates"| Aging
    Als{"Als"}
    P16 -->|"therapeutic_target"| Als
    Cancer{"Cancer"}
    P16 -->|"therapeutic_target"| Cancer
    AGING(["AGING"])
    AGING -->|"activates"| P16
    ERK(["ERK"])
    ERK -->|"activates"| P16
    CDKN2A(["CDKN2A"])
    CDKN2A -.->|"inhibits"| P16
    GENES(["GENES"])
    GENES -.->|"inhibits"| P16
    style P16 fill:#1a3a4a,stroke:#ce93d8,stroke-width:3px,color:#e0e0e0

Outgoing (272)

Target	Relation	Type	Str
Senescence	activates	disease	0.95
Aging	activates	disease	0.85
Als	therapeutic_target	disease	0.85
Senescence	therapeutic_target	disease	0.75
Senescence	inhibits	disease	0.75
Cancer	therapeutic_target	disease	0.75
Tumor	therapeutic_target	disease	0.75
Tumor	inhibits	disease	0.75
glioblastoma	associated_with	disease	0.70
RB1	regulates	protein	0.70
DNA	therapeutic_target	gene	0.70
Cell Cycle	activates	pathway	0.70
P21	regulates	gene	0.70
AKT	activates	gene	0.70
ALS	regulates	disease	0.65
Inflammation	regulates	disease	0.65
Cancer	associated_with	disease	0.65
Ms	therapeutic_target	disease	0.65
Glioblastoma	therapeutic_target	disease	0.65
Carcinoma	therapeutic_target	disease	0.65
Breast Cancer	contributes_to	disease	0.65
Cancer	contributes_to	disease	0.65
Tumor	activates	disease	0.65
Als	activates	disease	0.65
Longevity	activates	disease	0.65
Pancreatic Cancer	treats	disease	0.65
Cancer	treats	disease	0.65
Carcinoma	treats	disease	0.65
Sarcopenia	treats	disease	0.65
Aging	treats	disease	0.65
Als	treats	disease	0.65
Cancer	regulates	disease	0.65
Aging	regulates	disease	0.65
Als	expressed_in	disease	0.65
Senescence	expressed_in	disease	0.65
Osteoarthritis	therapeutic_target	disease	0.65
Cancer	activates	disease	0.65
Carcinoma	activates	disease	0.65
Pulmonary Fibrosis	inhibits	disease	0.65
Inflammation	inhibits	disease	0.65
Fibrosis	inhibits	disease	0.65
Senescence	biomarker_for	disease	0.65
Neurodegeneration	regulates	disease	0.65
Senescence	regulates	disease	0.65
Multiple Sclerosis	regulates	disease	0.65
Pancreatic Cancer	expressed_in	disease	0.65
Cancer	expressed_in	disease	0.65
Tumor	expressed_in	disease	0.65
Tumor	interacts_with	disease	0.65
Melanoma	therapeutic_target	disease	0.65

Incoming (163)

Source	Relation	Type	Str
AGING	activates	gene	0.70
ERK	activates	gene	0.70
CDKN2A	inhibits	gene	0.70
GENES	inhibits	gene	0.70
P53	activates	gene	0.70
CYTOKINES	activates	gene	0.60
P21	inhibits	gene	0.60
TERC	regulates	gene	0.60
GENES	regulates	gene	0.60
TERT	regulates	gene	0.60
INFLAMMATION	regulates	gene	0.60
CYTOKINES	regulates	gene	0.60
GENE MUTATIONS	associated_with	gene	0.60
MICRORNAS	therapeutic_target	gene	0.60
GBM	associated_with	gene	0.60
PTEN	therapeutic_target	gene	0.60
PI3K	therapeutic_target	gene	0.60
EGFR	therapeutic_target	gene	0.60
CANCER	therapeutic_target	gene	0.60
CYCLIN D1	contributes_to	gene	0.60
P53	contributes_to	gene	0.60
MDM2	contributes_to	gene	0.60
GENES	associated_with	gene	0.60
P21	activates	gene	0.60
GENES	activates	gene	0.60
KRAS	inhibits	gene	0.60
TP53	inhibits	gene	0.60
SMAD4	inhibits	gene	0.60
CANCER	treats	gene	0.60
AUTOPHAGY	inhibits	gene	0.60
SQSTM1	regulates	gene	0.60
CDKN1A	regulates	gene	0.60
MYOD	regulates	gene	0.60
ROS	treats	gene	0.60
OXIDATIVE STRESS	treats	gene	0.60
PI3K	treats	gene	0.60
P53	regulates	gene	0.60
MITOCHONDRIAL DYSFUNCTION	treats	gene	0.60
PSP	regulates	gene	0.60
GAL	treats	gene	0.60
CYP2E1	activates	gene	0.60
OXIDATIVE STRESS	activates	gene	0.60
PI3K	activates	gene	0.60
GAL	activates	gene	0.60
AGING	regulates	gene	0.60
CANCER	regulates	gene	0.60
APOPTOSIS	therapeutic_target	gene	0.60
TP53	therapeutic_target	gene	0.60
P53	therapeutic_target	gene	0.60
IL-6	therapeutic_target	gene	0.60

Targeting Hypotheses (1)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
Timed Senolytic Therapy Eliminates p16^Ink4a/p21^Cip1-Senesc	0.587	neuroinflammation	What molecular mechanisms drive the tran

Mentioning Analyses (2)

Scientific analyses that reference this entity

Can P16INK4A expression reliably distinguish harmful from beneficial senescent m

neurodegeneration | 2026-04-11 | 0 hypotheses

Senolytic therapy for age-related neurodegeneration

neurodegeneration | 2026-04-01 | 8 hypotheses Top: 0.703

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

P16

Understanding Entity Pages

Wiki Pages (20)

Microglial Senescence Pathway in Neurodegeneration

Cellular Senescence in Neurodegeneration

Longevity and Rejuvenation Therapies Landscape

cGAS-STING Signaling in Parkinson's Disease

Aging vs Neurodegeneration: Mechanistic Comparison Matrix

Cellular Senescence in Neurodegeneration

Senolytic Therapies for CBS and [PSP](/diseases/progressive-supranuclear-palsy)

Astrocyte Senescence Pathway in Neurodegeneration

CBS Microglial Neuroimmune Axis

Cyclin E2 (CCNE2) Protein

CDK6 Protein

Cellular Senescence Hypothesis in Parkinson's Disease

Cellular Senescence in Corticobasal Syndrome

Section 135: Telomere Biology and Anti-Aging Interventions in CBS/PSP

Microglial State Trajectory from Mobilization to Dysregulation in Alzheimer's Disease

Cellular Senescence in Brain Aging and Neurodegeneration

Cellular Senescence Therapeutic Targeting

BBB-Transcytosis Shuttle for Episodic CNS PROTAC Delivery

HERC2 Gene

Neurotransmitter Dysfunction in Progressive Supranuclear Palsy