gene

RET

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about RET: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

131Connections
3Hypotheses
10Analyses
50Outgoing
42Incoming

Summary

RET is a gene implicated in neurodegeneration research. Key relationships include: regulates, interacts with, activates. Associated with Als, Cancer, Carcinoma. Connected to 49 entities in the SciDEX knowledge graph.

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🧬 Gene Info
Gene SymbolRET
Chromosome10q11.21
Protein TypeReceptor
Functionis an important component in the neurobiology of neurodegenerative diseases.
Molecular Weight120 kDa
Amino Acids114 aa
Exons21
PathwaysPI3K, mTOR, mtor, MAPK
GeneCardsRET
Human Protein AtlasRET
IsoformExon Composition
RET9Excludes exon 11
RET10Includes exon 11
RET51Includes exons 11+12
PathwayKey Effectors
Associated DiseasesALS, Ataxia, Melanoma, Ms, Parkinson
InteractionsNRG1, EGFR, SRC, LMNA, KIF5B, OPTN
KG Connections131 knowledge graph edges
DatabasesGeneCardsUniProtNCBI GeneHPASTRING

Wiki Pages (21)

Knowledge base pages for this entity

Canonical Page

RET Gene

gene · 1125 words

Progressive Supranuclear Palsy (PSP)

disease · 12907 words

Parkinson's Disease

disease · 8807 words

Growth Factor Therapies

therapeutic · 4974 words

Growth Factor Therapeutics: Investment Landscape Analysis

investment · 4064 words

FOXO1 Protein

protein · 3787 words

Pathway Diagram

graph TD
    RET["<b>RET</b>"]
    Als{"Als"}
    RET -->|"inhibits"| Als
    Neuropathy{"Neuropathy"}
    RET -->|"inhibits"| Neuropathy
    Ms{"Ms"}
    RET -->|"activates"| Ms
    Cancer{"Cancer"}
    RET -->|"activates"| Cancer
    Tumor{"Tumor"}
    RET -->|"inhibits"| Tumor
    ERBB2["ERBB2"]
    RET -->|"inhibits"| ERBB2
    GENES["GENES"]
    RET -->|"associated with"| GENES
    ERBB3["ERBB3"]
    RET -->|"inhibits"| ERBB3
    NRG1["NRG1"]
    RET -->|"inhibits"| NRG1
    CANCER["CANCER"]
    RET -->|"activates"| CANCER
    EGFR["EGFR"]
    RET -->|"activates"| EGFR
    AND["AND"]
    RET -->|"inhibits"| AND
    style RET fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0

Outgoing (89)

TargetRelationTypeStr
neuronsexpressed_incell_type0.80
EGFRactivatesgene0.70
neurodegenerationregulatesdisease0.70
GENESassociated_withgene0.70
oxidative stress responseparticipates_inpathway0.70

Incoming (42)

SourceRelationTypeStr
GDNFactivatesgene0.80
GDNFregulatesgene0.70
MYO5Ainteracts_withgene0.60
NCOA4interacts_withgene0.60
CDKN2Ainteracts_withgene0.60

Targeting Hypotheses (3)

Hypotheses where this entity is a therapeutic target

HypothesisScoreDiseaseAnalysis
Retinal Vascular Microcirculation Rescue 0.542 neurodegeneration Digital biomarkers and AI-driven early d
P2RX7-Mediated Exosome Secretion Blockade 0.512 neurodegeneration Tau propagation mechanisms and therapeut
Hypocretin-Neurogenesis Coupling Therapy 0.452 neurodegeneration Sleep disruption as cause and consequenc

Mentioning Analyses (10)

Scientific analyses that reference this entity

What are the precise temporal dynamics of astrocyte ketone production decline du

neurodegeneration | 2026-04-15 | 2 hypotheses Top: 0.645

What are the physiological functions of BACE1 beyond APP processing that could c

neurodegeneration | 2026-04-15 | 1 hypotheses Top: 0.527

How can functional hyperconnectivity patterns distinguish compensatory mechanism

neurodegeneration | 2026-04-13 | 0 hypotheses

Do P2RX7 antagonists selectively block pathogenic exosomes while preserving bene

neurodegeneration | 2026-04-11 | 0 hypotheses

Do transferred mitochondria from diseased astrocytes carry pathological damage t

neurodegeneration | 2026-04-11 | 0 hypotheses

Related Papers (20)

Scientific publications cited in analyses involving this entity

Title & PMIDAuthorsJournalYearCitations
Pericyte-derived extracellular vesicles improve vascular barrier function in sep [PMID:39940043] Zhang ZS, Yang A, Luo X, Zhou HN, Liu YY Stem Cell Res Ther 2025 1
Irisin promotes fracture healing by improving osteogenesis and angiogenesis. [PMID:36196152] Kan T, He Z, Du J, Xu M, Cui J, Han X, T J Orthop Translat 2022 1
STING activation reprograms tumor vasculatures and synergizes with VEGFR2 blocka [PMID:31343989] Yang H, Lee WS, Kong SJ, Kim CG, Kim JH, J Clin Invest 2019 1
EMI1 switches from being a substrate to an inhibitor of APC/C(CDH1) to start the [PMID:29875408] Cappell SD, Mark KG, Garbett D, Pack LR, Nature 2018 1
Metabolic fate of glucose and candidate signaling and excess-fuel detoxification [PMID:28280244] Mugabo Y, Zhao S, Lamontagne J, Al-Mass J Biol Chem 2017 1
Sleep drives metabolite clearance from the adult brain. [PMID:24136970] Xie L, Kang H, Xu Q, Chen MJ, Liao Y, Th Science 2013 1
Exposure to 1800 MHz radiofrequency radiation induces oxidative damage to mitoch [PMID:19879861] Xu S, Zhou Z, Zhang L, Yu Z, Zhang W, Wa Brain Res 2010 1
Nucleotide signaling and cutaneous mechanisms of pain transduction. [PMID:19171165] Dussor G, Koerber HR, Oaklander AL, Rice Brain Res Rev 2009 1
Astrocyte-Glioblastoma Stem Cell Interactions via Extracellular Vesicles Contrib [PMID:41712235] Shirai Y, Tsuda M, Wang L, Oda Y, Sugizn Pathology international 2026 0
cGAMP promotes inner blood-retinal barrier breakdown through P2RX7-mediated tran [PMID:40025497] Ge X, Zhu X, Liu W, Li M, Zhang Z et al. J Neuroinflammation 2025 0
Clemastine fumarate accelerates accumulation of disability in progressive multip [PMID:40371642] Kocot J, Kosa P, Ashida S, Pirjanian NA, J Clin Invest 2025 0
CRISP3-PSP94 complex regulates P2RX7 mediated signalling in prostate cancer cell [PMID:40473221] Miya V, Pathak BR Biochim Biophys Acta Mol Cell 2025 0
P2RX7 regulates tauopathy progression via tau and mitochondria loading in extrac [PMID:40678243] Ikezu T, Bodart-Santos V, Ravula AR, You Res Sq 2025 0
Tissue-resident memory CD4(+) T cells infiltrate the CNS in progressive multiple [PMID:40700520] Pignata A, Frieser D, Gonzalez-Fierro C, Sci Transl Med 2025 0
P2RX7 modulates the function of human microglia-like cells and mediates the asso [PMID:40987420] Heavener KS, Tamucci KA, Lee AJ, Kabra K Neurobiol Dis 2025 0
P2RX7 Dynamics in CNS Disorders: Molecular Insights and Therapeutic Perspectives [PMID:41261310] Mithaiwala A, Thakur J, Godad A Mol Neurobiol 2025 0
Targeting hyperactive platelet-derived growth factor receptor-β signaling in T-c [PMID:37941480] ["De Coninck S", "De Smedt R", "Linterma Haematologica 2024 0
Inactivation of hypocretin receptor-2 signaling in dopaminergic neurons induces [PMID:38123729] Bandarabadi M, Li S, Aeschlimann L, Colo Molecular psychiatry 2024 0
Higher immune-related gene expression in major depression is independent of CRP [PMID:37264010] Sforzini L, Cattaneo A, Ferrari C, Turne Transl Psychiatry 2023 0
Fresh versus frozen embryo transfers in assisted reproduction. [PMID:33539543] ["Zaat T", "Zagers M", "Mol F", "Goddijn The Cochrane database of syste 2021 0