Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about RET: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
RET is a gene implicated in neurodegeneration research. Key relationships include: regulates, interacts with, activates. Associated with Als, Cancer, Carcinoma. Connected to 49 entities in the SciDEX knowledge graph.
| Gene Symbol | RET |
| Chromosome | 10q11.21 |
| Protein Type | Receptor |
| Function | is an important component in the neurobiology of neurodegenerative diseases. |
| Molecular Weight | 120 kDa |
| Amino Acids | 114 aa |
| Exons | 21 |
| Pathways | PI3K, mTOR, mtor, MAPK |
| GeneCards | RET |
| Human Protein Atlas | RET |
| Isoform | Exon Composition |
| RET9 | Excludes exon 11 |
| RET10 | Includes exon 11 |
| RET51 | Includes exons 11+12 |
| Pathway | Key Effectors |
| Associated Diseases | ALS, Ataxia, Melanoma, Ms, Parkinson |
| Interactions | NRG1, EGFR, SRC, LMNA, KIF5B, OPTN |
| KG Connections | 131 knowledge graph edges |
| Databases | GeneCardsUniProtNCBI GeneHPASTRING |
Knowledge base pages for this entity
graph TD
RET["<b>RET</b>"]
Als{"Als"}
RET -->|"inhibits"| Als
Neuropathy{"Neuropathy"}
RET -->|"inhibits"| Neuropathy
Ms{"Ms"}
RET -->|"activates"| Ms
Cancer{"Cancer"}
RET -->|"activates"| Cancer
Tumor{"Tumor"}
RET -->|"inhibits"| Tumor
ERBB2["ERBB2"]
RET -->|"inhibits"| ERBB2
GENES["GENES"]
RET -->|"associated with"| GENES
ERBB3["ERBB3"]
RET -->|"inhibits"| ERBB3
NRG1["NRG1"]
RET -->|"inhibits"| NRG1
CANCER["CANCER"]
RET -->|"activates"| CANCER
EGFR["EGFR"]
RET -->|"activates"| EGFR
AND["AND"]
RET -->|"inhibits"| AND
style RET fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0| Target | Relation | Type | Str |
|---|---|---|---|
| neurons | expressed_in | cell_type | 0.80 |
| EGFR | activates | gene | 0.70 |
| neurodegeneration | regulates | disease | 0.70 |
| GENES | associated_with | gene | 0.70 |
| oxidative stress response | participates_in | pathway | 0.70 |
| apoptosis pathway | participates_in | pathway | 0.70 |
| Als | inhibits | disease | 0.65 |
| Neuropathy | inhibits | disease | 0.65 |
| Ms | activates | disease | 0.65 |
| Cancer | activates | disease | 0.65 |
| Tumor | inhibits | disease | 0.65 |
| Glioma | regulates | disease | 0.65 |
| Cancer | regulates | disease | 0.65 |
| Carcinoma | regulates | disease | 0.65 |
| Tumor | interacts_with | disease | 0.65 |
| Melanoma | associated_with | disease | 0.65 |
| Tumor | therapeutic_target | disease | 0.65 |
| Glioma | therapeutic_target | disease | 0.65 |
| Cancer | therapeutic_target | disease | 0.65 |
| Als | therapeutic_target | disease | 0.65 |
| Autoimmune | inhibits | disease | 0.65 |
| Ms | associated_with | disease | 0.65 |
| Parkinson | associated_with | disease | 0.65 |
| Als | associated_with | disease | 0.65 |
| Ataxia | associated_with | disease | 0.65 |
| Neuropathy | transports | disease | 0.65 |
| NRG1 | inhibits | gene | 0.60 |
| GDNF | regulates | gene | 0.60 |
| SRC | activates | gene | 0.60 |
| LMNA | interacts_with | gene | 0.60 |
| KIF5B | interacts_with | gene | 0.60 |
| OPTN | interacts_with | gene | 0.60 |
| MYC | interacts_with | gene | 0.60 |
| OVERVIEW | therapeutic_target | gene | 0.60 |
| H3F3A | expressed_in | gene | 0.60 |
| TNF | activates | gene | 0.60 |
| SNCA | associated_with | gene | 0.60 |
| ATM | associated_with | gene | 0.60 |
| PINK1 | associated_with | gene | 0.60 |
| PTEN | associated_with | gene | 0.60 |
| MAP1B | transports | gene | 0.60 |
| TAU | transports | gene | 0.60 |
| DYNEIN | transports | gene | 0.60 |
| TRKB | regulates | gene | 0.60 |
| TRKC | regulates | gene | 0.60 |
| Schwann Cell | expressed_in | cell_type | 0.60 |
| Dynein | transports | protein | 0.60 |
| RIPK1 | activates | gene | 0.60 |
| RIPK3 | activates | gene | 0.60 |
| RIPK1 | inhibits | gene | 0.60 |
| Source | Relation | Type | Str |
|---|---|---|---|
| GDNF | activates | gene | 0.80 |
| GDNF | regulates | gene | 0.70 |
| MYO5A | interacts_with | gene | 0.60 |
| NCOA4 | interacts_with | gene | 0.60 |
| CDKN2A | interacts_with | gene | 0.60 |
| PTEN | expressed_in | gene | 0.60 |
| BRAF | therapeutic_target | gene | 0.60 |
| PKC | associated_with | gene | 0.60 |
| OVERVIEW | associated_with | gene | 0.60 |
| PARKIN | associated_with | gene | 0.60 |
| CDK5 | associated_with | gene | 0.60 |
| LRRK2 | associated_with | gene | 0.60 |
| TRKA | regulates | gene | 0.60 |
| MLKL | activates | gene | 0.60 |
| MLKL | inhibits | gene | 0.60 |
| GFRA1 | regulates | gene | 0.60 |
| AKT | protects_against | gene | 0.60 |
| ERK1 | protects_against | gene | 0.60 |
| GDNF | protects_against | gene | 0.60 |
| GFRA1 | protects_against | gene | 0.60 |
| PI3K | protects_against | gene | 0.60 |
| AKT | activates | gene | 0.60 |
| AKT | interacts_with | gene | 0.60 |
| ERK1 | interacts_with | gene | 0.60 |
| GDNF | interacts_with | gene | 0.60 |
| GFRA1 | interacts_with | gene | 0.60 |
| PI3K | interacts_with | gene | 0.60 |
| GDNF | expressed_in | gene | 0.60 |
| GDNF | inhibits | gene | 0.60 |
| CD33 | regulates | gene | 0.60 |
| CD55 | regulates | gene | 0.60 |
| EPHA1 | regulates | gene | 0.60 |
| PILRA | regulates | gene | 0.60 |
| PILRB | regulates | gene | 0.60 |
| ERK | regulates | gene | 0.60 |
| APOPTOSIS | activates | gene | 0.60 |
| PARKINSON | associated_with | gene | 0.60 |
| PARKINSON'S DISEASE | associated_with | gene | 0.60 |
| AMPK | associated_with | gene | 0.60 |
| MYELIN | expressed_in | gene | 0.60 |
| GSK3 | activates | gene | 0.60 |
| CANCER | associated_with | disease | 0.50 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| Retinal Vascular Microcirculation Rescue | 0.542 | neurodegeneration | Digital biomarkers and AI-driven early d |
| P2RX7-Mediated Exosome Secretion Blockade | 0.512 | neurodegeneration | Tau propagation mechanisms and therapeut |
| Hypocretin-Neurogenesis Coupling Therapy | 0.452 | neurodegeneration | Sleep disruption as cause and consequenc |
Scientific analyses that reference this entity
neurodegeneration | 2026-04-15 | 2 hypotheses Top: 0.645
neurodegeneration | 2026-04-15 | 1 hypotheses Top: 0.527
neurodegeneration | 2026-04-13 | 0 hypotheses
neurodegeneration | 2026-04-11 | 0 hypotheses
neurodegeneration | 2026-04-11 | 0 hypotheses
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| Pericyte-derived extracellular vesicles improve vascular barrier function in sep [PMID:39940043] | Zhang ZS, Yang A, Luo X, Zhou HN, Liu YY | Stem Cell Res Ther | 2025 | 1 |
| Irisin promotes fracture healing by improving osteogenesis and angiogenesis. [PMID:36196152] | Kan T, He Z, Du J, Xu M, Cui J, Han X, T | J Orthop Translat | 2022 | 1 |
| STING activation reprograms tumor vasculatures and synergizes with VEGFR2 blocka [PMID:31343989] | Yang H, Lee WS, Kong SJ, Kim CG, Kim JH, | J Clin Invest | 2019 | 1 |
| EMI1 switches from being a substrate to an inhibitor of APC/C(CDH1) to start the [PMID:29875408] | Cappell SD, Mark KG, Garbett D, Pack LR, | Nature | 2018 | 1 |
| Metabolic fate of glucose and candidate signaling and excess-fuel detoxification [PMID:28280244] | Mugabo Y, Zhao S, Lamontagne J, Al-Mass | J Biol Chem | 2017 | 1 |
| Sleep drives metabolite clearance from the adult brain. [PMID:24136970] | Xie L, Kang H, Xu Q, Chen MJ, Liao Y, Th | Science | 2013 | 1 |
| Exposure to 1800 MHz radiofrequency radiation induces oxidative damage to mitoch [PMID:19879861] | Xu S, Zhou Z, Zhang L, Yu Z, Zhang W, Wa | Brain Res | 2010 | 1 |
| Nucleotide signaling and cutaneous mechanisms of pain transduction. [PMID:19171165] | Dussor G, Koerber HR, Oaklander AL, Rice | Brain Res Rev | 2009 | 1 |
| Astrocyte-Glioblastoma Stem Cell Interactions via Extracellular Vesicles Contrib [PMID:41712235] | Shirai Y, Tsuda M, Wang L, Oda Y, Sugizn | Pathology international | 2026 | 0 |
| cGAMP promotes inner blood-retinal barrier breakdown through P2RX7-mediated tran [PMID:40025497] | Ge X, Zhu X, Liu W, Li M, Zhang Z et al. | J Neuroinflammation | 2025 | 0 |
| Clemastine fumarate accelerates accumulation of disability in progressive multip [PMID:40371642] | Kocot J, Kosa P, Ashida S, Pirjanian NA, | J Clin Invest | 2025 | 0 |
| CRISP3-PSP94 complex regulates P2RX7 mediated signalling in prostate cancer cell [PMID:40473221] | Miya V, Pathak BR | Biochim Biophys Acta Mol Cell | 2025 | 0 |
| P2RX7 regulates tauopathy progression via tau and mitochondria loading in extrac [PMID:40678243] | Ikezu T, Bodart-Santos V, Ravula AR, You | Res Sq | 2025 | 0 |
| Tissue-resident memory CD4(+) T cells infiltrate the CNS in progressive multiple [PMID:40700520] | Pignata A, Frieser D, Gonzalez-Fierro C, | Sci Transl Med | 2025 | 0 |
| P2RX7 modulates the function of human microglia-like cells and mediates the asso [PMID:40987420] | Heavener KS, Tamucci KA, Lee AJ, Kabra K | Neurobiol Dis | 2025 | 0 |
| P2RX7 Dynamics in CNS Disorders: Molecular Insights and Therapeutic Perspectives [PMID:41261310] | Mithaiwala A, Thakur J, Godad A | Mol Neurobiol | 2025 | 0 |
| Targeting hyperactive platelet-derived growth factor receptor-β signaling in T-c [PMID:37941480] | ["De Coninck S", "De Smedt R", "Linterma | Haematologica | 2024 | 0 |
| Inactivation of hypocretin receptor-2 signaling in dopaminergic neurons induces [PMID:38123729] | Bandarabadi M, Li S, Aeschlimann L, Colo | Molecular psychiatry | 2024 | 0 |
| Higher immune-related gene expression in major depression is independent of CRP [PMID:37264010] | Sforzini L, Cattaneo A, Ferrari C, Turne | Transl Psychiatry | 2023 | 0 |
| Fresh versus frozen embryo transfers in assisted reproduction. [PMID:33539543] | ["Zaat T", "Zagers M", "Mol F", "Goddijn | The Cochrane database of syste | 2021 | 0 |