NCOA4

Understanding Entity Pages

This page aggregates everything SciDEX knows about NCOA4: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

Summary

NCOA4 is a protein involved in neurodegeneration research. Key relationships include: associated with, regulates, activates. Associated with ALS, Aging, Als. Connected to 236 entities in the SciDEX knowledge graph.

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flowchart TD
    NCOA4["NCOA4<br/>(Nuclear Receptor<br/>Coactivator 4)"]
    
    FERRITINOPHAGY["Ferritinophagy<br/>(Iron Release<br/>from Ferritin)"]
    AUTOPHAGY["Autophagy<br/>(Cellular Degradation)"]
    FERROPTOSIS["Ferroptosis<br/>(Iron-dependent<br/>Cell Death)"]
    
    IRON_RELEASE["Free Iron<br/>Release"]
    IRON_OVERLOAD["Iron Overload<br/> and Oxidative Stress"]
    
    GPX4["GPX4<br/>(Glutathione<br/>Peroxidase 4)"]
    SLC7A11["SLC7A11<br/>(Cystine/Glutamate<br/>Antiporter)"]
    
    ALS["Amyotrophic<br/>Lateral Sclerosis<br/>(ALS)"]
    MS["Multiple<br/>Sclerosis<br/>(MS)"]
    PARKINSON["Parkinson's<br/>Disease"]
    
    NEURODEGENERATION["Neuronal<br/>Death and <br/>Degeneration"]
    THERAPEUTIC["Therapeutic<br/>Target"]
    
    NCOA4 --|"regulates"|--> FERRITINOPHAGY
    NCOA4 --|"regulates"|--> AUTOPHAGY
    NCOA4 --|"regulates"|--> FERROPTOSIS
    
    FERRITINOPHAGY --|"leads to"|--> IRON_RELEASE
    IRON_RELEASE --|"causes"|--> IRON_OVERLOAD
    IRON_OVERLOAD --|"promotes"|--> FERROPTOSIS
    
    NCOA4 --|"inhibits"|--> GPX4
    GPX4 --|"protects against"|--> FERROPTOSIS
    SLC7A11 --|"supports"|--> GPX4
    
    FERROPTOSIS --|"contributes to"|--> NEURODEGENERATION
    IRON_OVERLOAD --|"damages"|--> NEURODEGENERATION
    
    NEURODEGENERATION --|"manifests as"|--> ALS
    NEURODEGENERATION --|"manifests as"|--> MS
    NEURODEGENERATION --|"manifests as"|--> PARKINSON
    
    NCOA4 --|"potential"|--> THERAPEUTIC
    
    style NCOA4 fill:#006494
    style GPX4 fill:#1b5e20
    style SLC7A11 fill:#1b5e20
    style THERAPEUTIC fill:#1b5e20
    style FERROPTOSIS fill:#ef5350
    style IRON_OVERLOAD fill:#ef5350
    style NEURODEGENERATION fill:#ef5350
    style ALS fill:#5d4400
    style MS fill:#5d4400
    style PARKINSON fill:#5d4400
    style FERRITINOPHAGY fill:#4a1a6b
    style AUTOPHAGY fill:#4a1a6b