concept

MICROTUBULE

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about MICROTUBULE: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

29Connections
3Hypotheses
2Analyses
1Outgoing
6Incoming

No summary available yet. View on Wiki →

💡 Concept Info
NameMICROTUBULE
Linked Hypotheses7 hypotheses

Wiki Pages (20)

Knowledge base pages for this entity

cbs-psp-daily-action-plan

therapeutic · 30834 words

Personalized Treatment Plan — Atypical Parkinsonism (CBS/PSP)

therapeutic · 15794 words

Progressive Supranuclear Palsy (PSP)

disease · 12907 words

Corticobasal Syndrome (CBS)

disease · 11374 words

Novel Therapy Index

idea · 10647 words

Pathway Diagram

flowchart TD
    N0["MICROTUBULE"]
    N1["TAU"]
    N1 -->|"binds to"| N0
    N2["MAP6"]
    N2 -->|"binds to"| N0
    N3["LIS1"]
    N3 -->|"interacts with"| N0
    N4["DOUBLECORTIN"]
    N4 -->|"interacts with"| N0
    N5["NEURON"]
    N5 -->|"regulates"| N0
    N0 -->|"involved in"| N5

    classDef gene fill:#1a3a2a,stroke:#4caf50,color:#e0e0e0
    classDef protein fill:#1a2a3a,stroke:#4fc3f7,color:#e0e0e0
    classDef disease fill:#3a1a1a,stroke:#ef5350,color:#e0e0e0
    classDef pathway fill:#2a1a3a,stroke:#ce93d8,color:#e0e0e0
    classDef mechanism fill:#2a2a1a,stroke:#ffd54f,color:#e0e0e0
    classDef drug fill:#1a2a2a,stroke:#26c6da,color:#e0e0e0
    classDef cell_type fill:#2a1a2a,stroke:#ab47bc,color:#e0e0e0
    classDef phenotype fill:#2a2a1a,stroke:#ffa726,color:#e0e0e0
    classDef process fill:#1a2a2a,stroke:#66bb6a,color:#e0e0e0
    classDef biological_process fill:#1a2a2a,stroke:#66bb6a,color:#e0e0e0
    classDef concept fill:#1a1a2a,stroke:#7986cb,color:#e0e0e0
    classDef entity fill:#1a2a3a,stroke:#4fc3f7,color:#e0e0e0
    classDef therapeutic fill:#1a2a2a,stroke:#26c6da,color:#e0e0e0
    classDef index fill:#1a1a2a,stroke:#7986cb,color:#e0e0e0
    class N0 concept
    class N1 entity
    class N2 entity
    class N3 entity
    class N4 entity
    class N5 cell_type

Outgoing (6)

TargetRelationTypeStr
NEURONinvolved_inentity0.95

Incoming (23)

SourceRelationTypeStr
TAUbinds_toentity0.95
MAP6binds_toentity0.95
TAUregulatesentity0.95
MAP6regulatesentity0.95
LIS1interacts_withentity0.90

Targeting Hypotheses (3)

Hypotheses where this entity is a therapeutic target

HypothesisScoreDiseaseAnalysis
HDAC6 Selective Inhibition to Restore Acetylation Balance an 0.577 structural biology What is the atomic-resolution structure
Tau-Independent Microtubule Stabilization via MAP6 Enhanceme 0.480 neurodegeneration Selective vulnerability of entorhinal co
HDAC6 Inhibition for Dual Restoration of Microtubule Stabili 0.459 neurodegeneration Which tau PTMs are both disease-specific

Mentioning Analyses (2)

Scientific analyses that reference this entity

Should microtubule-stabilizing drugs be reconsidered as therapeutic targets for

neurodegeneration | 2026-04-15 | 2 hypotheses Top: 0.609

Do astrocytes functionally express TRIM46, and can PKCα phosphorylate it to driv

molecular biology | 2026-04-13 | 0 hypotheses

Related Papers (19)

Scientific publications cited in analyses involving this entity

Title & PMIDAuthorsJournalYearCitations
Tau and MAP6 establish labile and stable domains on microtubules. [PMID:40040809] Kirimtay K, Huang W, Sun X, Qiang L, Wan iScience 2025 1
Antagonistic roles of tau and MAP6 in regulating neuronal development. [PMID:39257379] Sun X, Yu W, Baas PW, Toyooka K, Qiang L J Cell Sci 2024 1
Beyond Neuronal Microtubule Stabilization: MAP6 and CRMPS, Two Converging Storie [PMID:34025352] Cuveillier C, Boulan B, Ravanello C, Den Front Mol Neurosci 2021 1
Tau: It's Not What You Think. [PMID:30929793] Baas PW, Qiang L Trends Cell Biol 2019 1
Stability properties of neuronal microtubules. [PMID:26887570] Baas PW, Rao AN, Matamoros AJ, Leo L Cytoskeleton (Hoboken) 2016 1
Targeting CXCL16-expressing macrophages with a biomimetic nanocarrier system att [PMID:41707770] Yang Q, Xu Y, Zhan Y, Li J, Peng R, Yu B Journal of controlled release 2026 0
The MAP6-NTS axis in hippocampal CA1 regulates synaptic plasticity and memory. [PMID:41825505] Jia Y, Lei J, Jiang Y, Xue L, Chen T, Wa Neuropharmacology 2026 0
BioID2-Based Tau Interactome Reveals Novel and Known Protein Interactions Associ [PMID:40910579] Atwa A, Alhadidy MM, Lamp J, Combs B, Ka Journal of proteome research 2025 0
Exosomes as nanocarriers for brain-targeted delivery of therapeutic nucleic acid [PMID:40533746] ["Sanadgol N", "Abedi M", "Hashemzaei M" Journal of nanobiotechnology 2025 0
ReMAPping the microtubule landscape: How phosphorylation dictates the activities [PMID:28980356] Ramkumar A, Jong BY, Ori-McKenney KM Developmental dynamics : an of 2018 0
Inferring patterns of folktale diffusion using genomic data. [PMID:28784786] ["Bortolini E", "Pagani L", "Crema E", " Proceedings of the National Ac 2017 0
Purification and Characterization of Progenitor and Mature Human Astrocytes Reve [PMID:26687838] ["Zhang Y", "Sloan S", "Clarke L", "Cane Neuron 2016 0
Amyloid-β oligomers induce synaptic damage via Tau-dependent microtubule severin [PMID:24065130] ["Zempel H", "Luedtke J", "Kumar Y", "Bi The EMBO journal 2013 0
Microtubules (tau) as an emerging therapeutic target: NAP (davunetide). [PMID:21902667] Gozes I Current pharmaceutical design 2011 0
Decreased neuroautonomic complexity in men during an acute major depressive epis [PMID:22832529] ["Leistedt S", "Linkowski P", "Lanquart Translational psychiatry 2011 0
Bidirectional activity-dependent plasticity at corticostriatal synapses. [PMID:16339023] ["Fino E", "Glowinski J", "Venance L"] The Journal of neuroscience : 2005 0
STOP proteins. [PMID:14567673] Bosc C, Andrieux A, Job D Biochemistry 2003 0
Ebselen: a substrate for human thioredoxin reductase strongly stimulating its hy [PMID:12070343] ["Zhao R", "Masayasu H", "Holmgren A"] Proceedings of the National Ac 2002 0
STOP proteins. [PMID:15218867] Bosc C, Oenarier E, Andrieux A, Job D Cell structure and function 1999 0