NDUFS5

Understanding Entity Pages

This page aggregates everything SciDEX knows about NDUFS5: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

Summary

NDUFS5 encodes a core accessory subunit of mitochondrial complex I essential for NADH oxidation and proton pumping. Implicated in Parkinson's disease, Leigh syndrome, and mitochondrial complex I deficiency through effects on oxidative phosphorylation.

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graph TD
    NDUFS5["<b>NDUFS5</b>"]
    Als{"Als"}
    NDUFS5 -->|"regulates"| Als
    Ms{"Ms"}
    NDUFS5 -->|"regulates"| Ms
    neurodegeneration["neurodegeneration"]
    NDUFS5 -->|"implicated in"| neurodegeneration
    NDUFA2["NDUFA2"]
    NDUFA2 -->|"associated with"| NDUFS5
    NDUFS6["NDUFS6"]
    NDUFS6 -->|"associated with"| NDUFS5
    NDUFA1["NDUFA1"]
    NDUFA1 -->|"associated with"| NDUFS5
    CBL["CBL"]
    CBL -->|"associated with"| NDUFS5
    PDGFRB["PDGFRB"]
    PDGFRB -->|"associated with"| NDUFS5
    HSP90AB1["HSP90AB1"]
    HSP90AB1 -->|"associated with"| NDUFS5
    CRKL["CRKL"]
    CRKL -->|"associated with"| NDUFS5
    DOCK1["DOCK1"]
    DOCK1 -->|"associated with"| NDUFS5
    NDUFA12["NDUFA12"]
    NDUFA12 -->|"associated with"| NDUFS5
    YWHAH["YWHAH"]
    YWHAH -->|"associated with"| NDUFS5
    style NDUFS5 fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0