Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about NDUFA1: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
NDUFA1 is a gene implicated in neurodegeneration research. Key relationships include: associated with, activates, causes. Associated with Als, Ms, Neurodegeneration. Connected to 21 entities in the SciDEX knowledge graph.
| Gene Symbol | NDUFA1 |
| Full Name | NDUFA1 |
| Protein Type | Gene |
| Function | NDUFA1 encodes a core subunit of NADH dehydrogenase (Complex I), the largest enzyme of the mitochondrial respiratory chain. |
| Pathways | Nf-Κb |
| NCBI Gene ID | Search NCBI |
| Ensembl ID | ENSG00000125351 |
| GeneCards | NDUFA1 |
| Human Protein Atlas | NDUFA1 |
| Associated Diseases | neurodegeneration |
| Interactions | CREB1, ROS, NEURODEGENERATION |
| KG Connections | 33 knowledge graph edges |
| Databases | GeneCardsUniProtHPASTRING |
Knowledge base pages for this entity
graph TD
NDUFA1["<b>NDUFA1</b>"]
Als{"Als"}
NDUFA1 -->|"regulates"| Als
Ms{"Ms"}
NDUFA1 -->|"regulates"| Ms
CBL["CBL"]
NDUFA1 -->|"associated with"| CBL
PDGFRB["PDGFRB"]
NDUFA1 -->|"associated with"| PDGFRB
HSP90AB1["HSP90AB1"]
NDUFA1 -->|"associated with"| HSP90AB1
CRKL["CRKL"]
NDUFA1 -->|"associated with"| CRKL
DOCK1["DOCK1"]
NDUFA1 -->|"associated with"| DOCK1
NDUFA12["NDUFA12"]
NDUFA1 -->|"associated with"| NDUFA12
YWHAH["YWHAH"]
NDUFA1 -->|"associated with"| YWHAH
NDUFS5["NDUFS5"]
NDUFA1 -->|"associated with"| NDUFS5
neurodegeneration["neurodegeneration"]
NDUFA1 -->|"implicated in"| neurodegeneration
NDUFA2["NDUFA2"]
NDUFA2 -->|"associated with"| NDUFA1
NDUFS6["NDUFS6"]
NDUFS6 -->|"associated with"| NDUFA1
style NDUFA1 fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0| Target | Relation | Type | Str |
|---|---|---|---|
| developmental defects | downregulates | phenotype | 0.82 |
| Als | regulates | disease | 0.65 |
| Ms | regulates | disease | 0.65 |
| Neurodegeneration | activates | disease | 0.65 |
| Alzheimer | regulates | disease | 0.65 |
| CBL | associated_with | gene | 0.60 |
| PDGFRB | associated_with | gene | 0.60 |
| HSP90AB1 | associated_with | gene | 0.60 |
| CRKL | associated_with | gene | 0.60 |
| DOCK1 | associated_with | gene | 0.60 |
| NDUFA12 | associated_with | gene | 0.60 |
| YWHAH | associated_with | gene | 0.60 |
| NDUFS5 | associated_with | gene | 0.60 |
| ABCA7 | regulates | gene | 0.60 |
| Oxidative Phosphorylation | activates | pathway | 0.60 |
| Nf-Κb | regulates | pathway | 0.60 |
| Source | Relation | Type | Str |
|---|---|---|---|
| NDUFA2 | associated_with | gene | 0.60 |
| NDUFS6 | associated_with | gene | 0.60 |
| CREB1 | activates | gene | 0.60 |
| TYK2 | regulates | gene | 0.60 |
| ABCA7 | regulates | gene | 0.60 |
| NAD | causes | gene | 0.60 |
| ROS | activates | gene | 0.60 |
| NEURODEGENERATION | activates | gene | 0.60 |
| MITOCHONDRIAL DYSFUNCTION | causes | gene | 0.60 |
| MITOCHONDRIA | causes | gene | 0.60 |
| ALZHEIMER | regulates | gene | 0.60 |
| GENES | regulates | gene | 0.60 |
| MITOCHONDRIAL DYSFUNCTION | regulates | gene | 0.60 |
| NF-ΚB | regulates | gene | 0.60 |
| INOS | regulates | gene | 0.60 |
| AND | regulates | gene | 0.60 |
| ALZHEIMER'S DISEASE | regulates | gene | 0.60 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| No targeting hypotheses | |||
Scientific analyses that reference this entity
No analyses mention this entity
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||