gene

NDUFA1

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about NDUFA1: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

33Connections
0Hypotheses
0Analyses
16Outgoing
17Incoming

Summary

NDUFA1 is a gene implicated in neurodegeneration research. Key relationships include: associated with, activates, causes. Associated with Als, Ms, Neurodegeneration. Connected to 21 entities in the SciDEX knowledge graph.

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🧬 Gene Info
Gene SymbolNDUFA1
Full NameNDUFA1
Protein TypeGene
FunctionNDUFA1 encodes a core subunit of NADH dehydrogenase (Complex I), the largest enzyme of the mitochondrial respiratory chain.
PathwaysNf-Κb
NCBI Gene IDSearch NCBI
Ensembl IDENSG00000125351
GeneCardsNDUFA1
Human Protein AtlasNDUFA1
Associated Diseasesneurodegeneration
InteractionsCREB1, ROS, NEURODEGENERATION
KG Connections33 knowledge graph edges
DatabasesGeneCardsUniProtHPASTRING

Wiki Pages (11)

Knowledge base pages for this entity

Canonical Page

NDUFA1 Gene

gene · 530 words

DOCK1 Gene

gene · 2503 words

NDUFA12 Gene

gene · 2177 words

YWHAH Gene — 14-3-3 Eta (η) Protein

gene · 2068 words

Spatial Transcriptomics of Progressive Supranuclear Palsy

mechanism · 1780 words

NDUFS6 Gene

gene · 1646 words

Pathway Diagram

graph TD
    NDUFA1["<b>NDUFA1</b>"]
    Als{"Als"}
    NDUFA1 -->|"regulates"| Als
    Ms{"Ms"}
    NDUFA1 -->|"regulates"| Ms
    CBL["CBL"]
    NDUFA1 -->|"associated with"| CBL
    PDGFRB["PDGFRB"]
    NDUFA1 -->|"associated with"| PDGFRB
    HSP90AB1["HSP90AB1"]
    NDUFA1 -->|"associated with"| HSP90AB1
    CRKL["CRKL"]
    NDUFA1 -->|"associated with"| CRKL
    DOCK1["DOCK1"]
    NDUFA1 -->|"associated with"| DOCK1
    NDUFA12["NDUFA12"]
    NDUFA1 -->|"associated with"| NDUFA12
    YWHAH["YWHAH"]
    NDUFA1 -->|"associated with"| YWHAH
    NDUFS5["NDUFS5"]
    NDUFA1 -->|"associated with"| NDUFS5
    neurodegeneration["neurodegeneration"]
    NDUFA1 -->|"implicated in"| neurodegeneration
    NDUFA2["NDUFA2"]
    NDUFA2 -->|"associated with"| NDUFA1
    NDUFS6["NDUFS6"]
    NDUFS6 -->|"associated with"| NDUFA1
    style NDUFA1 fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0

Outgoing (16)

TargetRelationTypeStr
developmental defectsdownregulatesphenotype0.82
Alsregulatesdisease0.65
Msregulatesdisease0.65
Neurodegenerationactivatesdisease0.65
Alzheimerregulatesdisease0.65

Incoming (17)

SourceRelationTypeStr
NDUFA2associated_withgene0.60
NDUFS6associated_withgene0.60
CREB1activatesgene0.60
TYK2regulatesgene0.60
ABCA7regulatesgene0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

HypothesisScoreDiseaseAnalysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMIDAuthorsJournalYearCitations
No papers found