Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about YWHAH: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
14-3-3 eta protein: adapter/scaffold protein with critical roles in signal transduction, apoptosis regulation, and neurodegenerative disease pathogenesis.
| Gene Symbol | YWHAH |
| Full Name | Tyrosine 3-Monooxygenase/Tryptophan 5-Monooxygenase Activation Protein Eta |
| Aliases | 14-3-3 Eta (η) Protein |
| Chromosome | 22q12.3 |
| Function | Phosphorylation: Affects target protein binding affinity |
| Primary Expression | all eukaryotic cells[@yau2015] |
| Molecular Weight | 28 kDa |
| Amino Acids | 246 aa |
| Exons | 6 |
| UniProt ID | Q9Y2H5 |
| NCBI Gene ID | 7535 |
| Ensembl ID | ENSG00000128245 |
| OMIM | 608456 |
| GeneCards | YWHAH |
| Human Protein Atlas | YWHAH |
| Associated Diseases | neurodegeneration |
| Interactions | FUS, IL-6, YES1, SOX9, HNRNPA2B1, AND |
| KG Connections | 25 knowledge graph edges |
| Databases | GeneCardsHPASTRING |
Knowledge base pages for this entity
graph TD
YWHAH["<b>YWHAH</b>"]
Als{"Als"}
YWHAH -->|"regulates"| Als
Ms{"Ms"}
YWHAH -->|"regulates"| Ms
NDUFS5["NDUFS5"]
YWHAH -->|"associated with"| NDUFS5
neurodegeneration["neurodegeneration"]
YWHAH -->|"implicated in"| neurodegeneration
NDUFA2["NDUFA2"]
NDUFA2 -->|"associated with"| YWHAH
NDUFS6["NDUFS6"]
NDUFS6 -->|"associated with"| YWHAH
NDUFA1["NDUFA1"]
NDUFA1 -->|"associated with"| YWHAH
CBL["CBL"]
CBL -->|"associated with"| YWHAH
PDGFRB["PDGFRB"]
PDGFRB -->|"associated with"| YWHAH
HSP90AB1["HSP90AB1"]
HSP90AB1 -->|"associated with"| YWHAH
CRKL["CRKL"]
CRKL -->|"associated with"| YWHAH
DOCK1["DOCK1"]
DOCK1 -->|"associated with"| YWHAH
NDUFA12["NDUFA12"]
NDUFA12 -->|"associated with"| YWHAH
style YWHAH fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0| Source | Relation | Type | Str |
|---|---|---|---|
| circEHD2 | interacts_with | gene | 0.85 |
| NDUFA2 | associated_with | gene | 0.60 |
| NDUFS6 | associated_with | gene | 0.60 |
| NDUFA1 | associated_with | gene | 0.60 |
| CBL | associated_with | gene | 0.60 |
| PDGFRB | associated_with | gene | 0.60 |
| HSP90AB1 | associated_with | gene | 0.60 |
| CRKL | associated_with | gene | 0.60 |
| DOCK1 | associated_with | gene | 0.60 |
| NDUFA12 | associated_with | gene | 0.60 |
| YES1 | activates | gene | 0.60 |
| SOX9 | activates | gene | 0.60 |
| HNRNPA2B1 | activates | gene | 0.60 |
| AND | activates | gene | 0.60 |
| CYTOKINES | activates | gene | 0.60 |
| CANCER | activates | gene | 0.60 |
| YAP | activates | gene | 0.60 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| No targeting hypotheses | |||
Scientific analyses that reference this entity
No analyses mention this entity
Experimental studies targeting or related to this entity
| Experiment | Type | Disease | Score | Feasibility | Model | Status | Est. Cost |
|---|---|---|---|---|---|---|---|
| No experiments found | |||||||
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||