protein

YWHAH

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about YWHAH: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

25Connections
0Hypotheses
0Analyses
8Outgoing
17Incoming
0Experiments

Summary

14-3-3 eta protein: adapter/scaffold protein with critical roles in signal transduction, apoptosis regulation, and neurodegenerative disease pathogenesis.

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🔬 Protein Info
Gene SymbolYWHAH
Full NameTyrosine 3-Monooxygenase/Tryptophan 5-Monooxygenase Activation Protein Eta
Aliases14-3-3 Eta (η) Protein
Chromosome22q12.3
FunctionPhosphorylation: Affects target protein binding affinity
Primary Expressionall eukaryotic cells[@yau2015]
Molecular Weight28 kDa
Amino Acids246 aa
Exons6
UniProt IDQ9Y2H5
NCBI Gene ID7535
Ensembl IDENSG00000128245
OMIM608456
GeneCardsYWHAH
Human Protein AtlasYWHAH
Associated Diseasesneurodegeneration
InteractionsFUS, IL-6, YES1, SOX9, HNRNPA2B1, AND
KG Connections25 knowledge graph edges
DatabasesGeneCardsHPASTRING
🔮 Predicted Structure: YWHAH — AlphaFold Q9Y2H5 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (15)

Knowledge base pages for this entity

Canonical Page

YWHAH Gene — 14-3-3 Eta (η) Protein

gene · 2068 words

DOCK1 Gene

gene · 2503 words

NDUFA12 Gene

gene · 2177 words

YWHAZ Gene

gene · 2161 words

YWHAH Protein (14-3-3 Eta)

protein · 1947 words

NDUFS6 Gene

gene · 1646 words

Pathway Diagram

graph TD
    YWHAH["<b>YWHAH</b>"]
    Als{"Als"}
    YWHAH -->|"regulates"| Als
    Ms{"Ms"}
    YWHAH -->|"regulates"| Ms
    NDUFS5["NDUFS5"]
    YWHAH -->|"associated with"| NDUFS5
    neurodegeneration["neurodegeneration"]
    YWHAH -->|"implicated in"| neurodegeneration
    NDUFA2["NDUFA2"]
    NDUFA2 -->|"associated with"| YWHAH
    NDUFS6["NDUFS6"]
    NDUFS6 -->|"associated with"| YWHAH
    NDUFA1["NDUFA1"]
    NDUFA1 -->|"associated with"| YWHAH
    CBL["CBL"]
    CBL -->|"associated with"| YWHAH
    PDGFRB["PDGFRB"]
    PDGFRB -->|"associated with"| YWHAH
    HSP90AB1["HSP90AB1"]
    HSP90AB1 -->|"associated with"| YWHAH
    CRKL["CRKL"]
    CRKL -->|"associated with"| YWHAH
    DOCK1["DOCK1"]
    DOCK1 -->|"associated with"| YWHAH
    NDUFA12["NDUFA12"]
    NDUFA12 -->|"associated with"| YWHAH
    style YWHAH fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0

Outgoing (8)

TargetRelationTypeStr
Alsregulatesdisease0.65
Msregulatesdisease0.65
Carcinomaactivatesdisease0.65
Canceractivatesdisease0.65
Tumoractivatesdisease0.65

Incoming (17)

SourceRelationTypeStr
circEHD2interacts_withgene0.85
NDUFA2associated_withgene0.60
NDUFS6associated_withgene0.60
NDUFA1associated_withgene0.60
CBLassociated_withgene0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

HypothesisScoreDiseaseAnalysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

ExperimentTypeDiseaseScoreFeasibilityModelStatusEst. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMIDAuthorsJournalYearCitations
No papers found