Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about CBL: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
CBL is a gene implicated in neurodegeneration research. Key relationships include: activates, interacts with, associated with. Associated with Aging, Als, Alzheimer. Connected to 83 entities in the SciDEX knowledge graph.
| Gene Symbol | CBL |
| Full Name | Casitas B-lineage Lymphoma |
| Chromosome | 11q23.3 |
| Protein Type | Ligase |
| Function | encodes a RING-type E3 ubiquitin ligase that serves as a critical negative regulator of receptor tyrosine kinase (RTK) signaling. |
| Molecular Weight | 100 kDa |
| Amino Acids | 906 aa |
| Pathways | Inflammasome |
| UniProt ID | [P22681](https://www.uniprot.org/uniprot/P22681) |
| Ensembl ID | ENSG00000110395 |
| GeneCards | CBL |
| Human Protein Atlas | CBL |
| Linker Region | Connects TKB and RING domains, regulatory function |
| C-terminal Proline-Rich Region | Mediates protein-protein interactions with SH3 domain-containing proteins |
| UEV Domain | Ubiquitin-conjugating enzyme variant, substrate recognition |
| Associated Diseases | ALS, Alzheimer, Infection, Inflammation, Lymphoma |
| Interactions | FOXO4, AKT, RHOA, TRAF2, TRAF6, TGFBR1 |
| KG Connections | 157 knowledge graph edges |
| Databases | GeneCardsNCBI GeneHPASTRING |
Knowledge base pages for this entity
graph TD
CBL["<b>CBL</b>"]
Traumatic_Brain_Injury{"Traumatic Brain Injury"}
CBL -->|"therapeutic target"| Traumatic_Brain_Injury
Als{"Als"}
CBL -->|"therapeutic target"| Als
CBL -->|"regulates"| Als
Ms{"Ms"}
CBL -->|"regulates"| Ms
Aging{"Aging"}
CBL -->|"interacts with"| Aging
CBL -->|"interacts with"| Als
Cancer{"Cancer"}
CBL -->|"interacts with"| Cancer
Lymphoma{"Lymphoma"}
CBL -->|"associated with"| Lymphoma
Tumor{"Tumor"}
CBL -->|"interacts with"| Tumor
FOXO4["FOXO4"]
CBL -->|"activates"| FOXO4
PDGFRB["PDGFRB"]
CBL -->|"associated with"| PDGFRB
HSP90AB1["HSP90AB1"]
CBL -->|"associated with"| HSP90AB1
NDUFA2["NDUFA2"]
NDUFA2 -->|"associated with"| CBL
NDUFS6["NDUFS6"]
NDUFS6 -->|"associated with"| CBL
NDUFA1["NDUFA1"]
NDUFA1 -->|"associated with"| CBL
PIK3CA["PIK3CA"]
PIK3CA -->|"associated with"| CBL
RANKINGS["RANKINGS"]
RANKINGS -->|"associated with"| CBL
RAC1["RAC1"]
RAC1 -->|"interacts with"| CBL
MAPK1["MAPK1"]
MAPK1 -->|"associated with"| CBL
PI3K["PI3K"]
PI3K -->|"interacts with"| CBL
style CBL fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0| Target | Relation | Type | Str |
|---|---|---|---|
| HNRNPA2B1 | degrades | protein | 0.92 |
| Hnrnpa2B1 | degrades | protein | 0.88 |
| Als | activates | disease | 0.75 |
| Inflammation | activates | disease | 0.75 |
| Mapk | associated_with | pathway | 0.70 |
| Traumatic Brain Injury | therapeutic_target | disease | 0.65 |
| Als | therapeutic_target | disease | 0.65 |
| Als | regulates | disease | 0.65 |
| Ms | regulates | disease | 0.65 |
| Aging | interacts_with | disease | 0.65 |
| Als | interacts_with | disease | 0.65 |
| Cancer | interacts_with | disease | 0.65 |
| Lymphoma | associated_with | disease | 0.65 |
| Tumor | interacts_with | disease | 0.65 |
| Metabolic Syndrome | activates | disease | 0.65 |
| Insulin Resistance | activates | disease | 0.65 |
| Melanoma | inhibits | disease | 0.65 |
| Infection | causes | disease | 0.65 |
| Als | causes | disease | 0.65 |
| Inflammation | causes | disease | 0.65 |
| Alzheimer | causes | disease | 0.65 |
| Neurodegeneration | causes | disease | 0.65 |
| Lymphoma | regulates | disease | 0.65 |
| Ms | associated_with | disease | 0.65 |
| Als | associated_with | disease | 0.65 |
| Als | inhibits | disease | 0.65 |
| Neuroinflammation | inhibits | disease | 0.65 |
| Traumatic Brain Injury | inhibits | disease | 0.65 |
| Tumor | activates | disease | 0.65 |
| ALS | inhibits | disease | 0.65 |
| Inflammation | inhibits | disease | 0.65 |
| FOXO4 | activates | gene | 0.60 |
| PDGFRB | associated_with | gene | 0.60 |
| HSP90AB1 | associated_with | gene | 0.60 |
| CRKL | associated_with | gene | 0.60 |
| DOCK1 | associated_with | gene | 0.60 |
| NDUFA12 | associated_with | gene | 0.60 |
| YWHAH | associated_with | gene | 0.60 |
| NDUFS5 | associated_with | gene | 0.60 |
| AKT | interacts_with | gene | 0.60 |
| RHOA | interacts_with | gene | 0.60 |
| TRAF2 | interacts_with | gene | 0.60 |
| TRAF6 | interacts_with | gene | 0.60 |
| TGFBR1 | interacts_with | gene | 0.60 |
| PTEN | associated_with | gene | 0.60 |
| RAF1 | interacts_with | gene | 0.60 |
| CDC42 | interacts_with | gene | 0.60 |
| ACVR1 | interacts_with | gene | 0.60 |
| PI3K | activates | gene | 0.60 |
| AKT | activates | gene | 0.60 |
| Source | Relation | Type | Str |
|---|---|---|---|
| LNK | interacts_with | protein | 0.95 |
| NDUFA2 | associated_with | gene | 0.60 |
| NDUFS6 | associated_with | gene | 0.60 |
| NDUFA1 | associated_with | gene | 0.60 |
| PIK3CA | associated_with | gene | 0.60 |
| RANKINGS | associated_with | gene | 0.60 |
| RAC1 | interacts_with | gene | 0.60 |
| MAPK1 | associated_with | gene | 0.60 |
| PI3K | interacts_with | gene | 0.60 |
| NRAS | associated_with | gene | 0.60 |
| BRAF | associated_with | gene | 0.60 |
| RAF1 | associated_with | gene | 0.60 |
| TLR4 | inhibits | gene | 0.60 |
| TLR2 | inhibits | gene | 0.60 |
| TNF | inhibits | gene | 0.60 |
| BAX | inhibits | gene | 0.60 |
| MAPK | associated_with | gene | 0.60 |
| KRAS | associated_with | gene | 0.60 |
| TLR | inhibits | gene | 0.60 |
| ROS | inhibits | gene | 0.60 |
| APOPTOSIS | inhibits | gene | 0.60 |
| NEUROINFLAMMATION | inhibits | gene | 0.60 |
| CYTOKINES | activates | gene | 0.60 |
| BRAIN INJURY | inhibits | gene | 0.60 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| No targeting hypotheses | |||
Scientific analyses that reference this entity
No analyses mention this entity
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||