gene

CBL

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about CBL: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

157Connections
0Hypotheses
0Analyses
50Outgoing
24Incoming

Summary

CBL is a gene implicated in neurodegeneration research. Key relationships include: activates, interacts with, associated with. Associated with Aging, Als, Alzheimer. Connected to 83 entities in the SciDEX knowledge graph.

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🧬 Gene Info
Gene SymbolCBL
Full NameCasitas B-lineage Lymphoma
Chromosome11q23.3
Protein TypeLigase
Functionencodes a RING-type E3 ubiquitin ligase that serves as a critical negative regulator of receptor tyrosine kinase (RTK) signaling.
Molecular Weight100 kDa
Amino Acids906 aa
PathwaysInflammasome
UniProt ID[P22681](https://www.uniprot.org/uniprot/P22681)
Ensembl IDENSG00000110395
GeneCardsCBL
Human Protein AtlasCBL
Linker RegionConnects TKB and RING domains, regulatory function
C-terminal Proline-Rich RegionMediates protein-protein interactions with SH3 domain-containing proteins
UEV DomainUbiquitin-conjugating enzyme variant, substrate recognition
Associated DiseasesALS, Alzheimer, Infection, Inflammation, Lymphoma
InteractionsFOXO4, AKT, RHOA, TRAF2, TRAF6, TGFBR1
KG Connections157 knowledge graph edges
DatabasesGeneCardsNCBI GeneHPASTRING

Wiki Pages (21)

Knowledge base pages for this entity

Canonical Page

CBL Gene

gene · 1026 words

rankings

institution · 4086 words

CD200R1 Gene

gene · 3138 words

DOCK1 Gene

gene · 2503 words

LCK Protein (Lymphocyte-Specific Protein Tyrosine Kinase)

protein · 2373 words

Mechanism Rankings

mechanism · 2096 words

Pathway Diagram

graph TD
    CBL["<b>CBL</b>"]
    Traumatic_Brain_Injury{"Traumatic Brain Injury"}
    CBL -->|"therapeutic target"| Traumatic_Brain_Injury
    Als{"Als"}
    CBL -->|"therapeutic target"| Als
    CBL -->|"regulates"| Als
    Ms{"Ms"}
    CBL -->|"regulates"| Ms
    Aging{"Aging"}
    CBL -->|"interacts with"| Aging
    CBL -->|"interacts with"| Als
    Cancer{"Cancer"}
    CBL -->|"interacts with"| Cancer
    Lymphoma{"Lymphoma"}
    CBL -->|"associated with"| Lymphoma
    Tumor{"Tumor"}
    CBL -->|"interacts with"| Tumor
    FOXO4["FOXO4"]
    CBL -->|"activates"| FOXO4
    PDGFRB["PDGFRB"]
    CBL -->|"associated with"| PDGFRB
    HSP90AB1["HSP90AB1"]
    CBL -->|"associated with"| HSP90AB1
    NDUFA2["NDUFA2"]
    NDUFA2 -->|"associated with"| CBL
    NDUFS6["NDUFS6"]
    NDUFS6 -->|"associated with"| CBL
    NDUFA1["NDUFA1"]
    NDUFA1 -->|"associated with"| CBL
    PIK3CA["PIK3CA"]
    PIK3CA -->|"associated with"| CBL
    RANKINGS["RANKINGS"]
    RANKINGS -->|"associated with"| CBL
    RAC1["RAC1"]
    RAC1 -->|"interacts with"| CBL
    MAPK1["MAPK1"]
    MAPK1 -->|"associated with"| CBL
    PI3K["PI3K"]
    PI3K -->|"interacts with"| CBL
    style CBL fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0

Outgoing (133)

TargetRelationTypeStr
HNRNPA2B1degradesprotein0.92
Hnrnpa2B1degradesprotein0.88
Alsactivatesdisease0.75
Inflammationactivatesdisease0.75
Mapkassociated_withpathway0.70

Incoming (24)

SourceRelationTypeStr
LNKinteracts_withprotein0.95
NDUFA2associated_withgene0.60
NDUFS6associated_withgene0.60
NDUFA1associated_withgene0.60
PIK3CAassociated_withgene0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

HypothesisScoreDiseaseAnalysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMIDAuthorsJournalYearCitations
No papers found