gene

HSP90AB1

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about HSP90AB1: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

191Connections

0Hypotheses

0Analyses

50Outgoing

50Incoming

Summary

HSP90AB1 is a gene implicated in neurodegeneration research. Key relationships include: expressed in, interacts with, associated with. Associated with Aging, Als, Alzheimer. Connected to 103 entities in the SciDEX knowledge graph.

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🧬 Gene Info

Gene Symbol	HSP90AB1
Chromosome	6p21.1
Molecular Weight	90 kDa
Amino Acids	724 aa
Exons	11
Pathways	Lipid Metabolism, Autophagy, Blood-Brain Barrier, Mapk, Apoptosis
GeneCards	HSP90AB1
Human Protein Atlas	HSP90AB1
Category	Client Proteins
Kinases	AKT, RAF, SRC
Steroid receptors	ER, PR, AR
Transcription factors	p53, HIF-1α
Cell cycle	CDK4, CDK6
Chaperones	HSP70, HSP40
Disease	HSP90AB1 Role
Associated Diseases	Aging, Als, Cancer, Ms
Interactions	ACTB, CDC42, ATP5A1, SOD1, EGFR, SNCA
KG Connections	191 knowledge graph edges
Databases	GeneCards UniProt NCBI Gene HPA STRING

Wiki Pages (21)

Knowledge base pages for this entity

Canonical Page

Pathway Diagram

graph TD
    HSP90AB1["HSP90AB1"]
    HSP90AB1 -->|"expressed in"| Alzheimer["Alzheimer"]
    HSP90AB1 -->|"expressed in"| Aging["Aging"]
    HSP90AB1 -->|"expressed in"| Als["Als"]
    HSP90AB1 -->|"expressed in"| Ms["Ms"]
    HSP90AB1 -->|"expressed in"| Dementia["Dementia"]
    HSP90AB1 -->|"target for"| Parkinson["Parkinson"]
    HSP90AB1 -->|"target for"| Huntington["Huntington"]
    HSP90AB1 -->|"expressed in"| Lymphoma["Lymphoma"]
    FYN["FYN"] -->|"expressed in"| HSP90AB1
    AGING["AGING"] -->|"expressed in"| HSP90AB1
    VCP["VCP"] -->|"expressed in"| HSP90AB1
    CTNNB1["CTNNB1"] -->|"expressed in"| HSP90AB1
    ALZHEIMER_S_DISEASE["ALZHEIMER'S DISEASE"] -->|"expressed in"| HSP90AB1
    EGFR["EGFR"] -->|"expressed in"| HSP90AB1
    HSP90AA1["HSP90AA1"] -->|"expressed in"| HSP90AB1
    APP["APP"] -->|"expressed in"| HSP90AB1
    CCT2["CCT2"] -->|"interacts"| HSP90AB1

Outgoing (112)

Target	Relation	Type	Str
Aging	associated_with	disease	0.65
Ms	associated_with	disease	0.65
Alzheimer	expressed_in	disease	0.65
Aging	expressed_in	disease	0.65
Als	expressed_in	disease	0.65
Ms	expressed_in	disease	0.65
Dementia	expressed_in	disease	0.65
Parkinson	therapeutic_target	disease	0.65
Alzheimer	therapeutic_target	disease	0.65
Huntington	therapeutic_target	disease	0.65
Ms	therapeutic_target	disease	0.65
Lymphoma	expressed_in	disease	0.65
Cancer	expressed_in	disease	0.65
Tumor	expressed_in	disease	0.65
Als	interacts_with	disease	0.65
Ms	interacts_with	disease	0.65
Cancer	interacts_with	disease	0.65
Tumor	interacts_with	disease	0.65
Als	regulates	disease	0.65
Ms	regulates	disease	0.65
Cancer	associated_with	disease	0.65
Als	associated_with	disease	0.65
Prion	therapeutic_target	disease	0.65
ALS	expressed_in	disease	0.65
MAP1LC3B	associated_with	gene	0.60
MDM2	expressed_in	gene	0.60
HSF1	expressed_in	gene	0.60
GRB2	expressed_in	gene	0.60
UBC	expressed_in	gene	0.60
CELF2	expressed_in	gene	0.60
JUN	expressed_in	gene	0.60
ACTB	interacts_with	gene	0.60
CDC42	interacts_with	gene	0.60
ATP5A1	interacts_with	gene	0.60
SOD1	interacts_with	gene	0.60
EGFR	interacts_with	gene	0.60
HSP70	expressed_in	gene	0.60
HSPH1	expressed_in	gene	0.60
HSPA1L	expressed_in	gene	0.60
HSPA1A	expressed_in	gene	0.60
DNAJC10	expressed_in	gene	0.60
KIF4A	associated_with	gene	0.60
JUN	associated_with	gene	0.60
CRKL	associated_with	gene	0.60
DOCK1	associated_with	gene	0.60
NDUFA12	associated_with	gene	0.60
YWHAH	associated_with	gene	0.60
NDUFS5	associated_with	gene	0.60
HSPA1A	therapeutic_target	gene	0.60
AKT	therapeutic_target	gene	0.60

Incoming (79)

Source	Relation	Type	Str
PLIN1	associated_with	gene	0.60
FYN	expressed_in	gene	0.60
VCP	expressed_in	gene	0.60
CTNNB1	expressed_in	gene	0.60
EGFR	expressed_in	gene	0.60
HSP90AA1	expressed_in	gene	0.60
APP	expressed_in	gene	0.60
CCT2	interacts_with	gene	0.60
GFAP	interacts_with	gene	0.60
GRIA1	interacts_with	gene	0.60
SNAP25	interacts_with	gene	0.60
ACTG1	interacts_with	gene	0.60
SNCA	interacts_with	gene	0.60
GAPDH	interacts_with	gene	0.60
MAPK1	interacts_with	gene	0.60
PSMA3	interacts_with	gene	0.60
SOX2	interacts_with	gene	0.60
YWHAZ	interacts_with	gene	0.60
UBIQUITIN	expressed_in	gene	0.60
BAG3	expressed_in	gene	0.60
UBC	expressed_in	gene	0.60
HSPD1	expressed_in	gene	0.60
DNAJC7	expressed_in	gene	0.60
HSPA6	expressed_in	gene	0.60
DNAJB1	expressed_in	gene	0.60
IKBKB	expressed_in	gene	0.60
HSPA1B	expressed_in	gene	0.60
HSPE1	expressed_in	gene	0.60
KIF20A	associated_with	gene	0.60
UBIQUITIN	interacts_with	gene	0.60
CD8	interacts_with	gene	0.60
NDUFA2	associated_with	gene	0.60
NDUFS6	associated_with	gene	0.60
NDUFA1	associated_with	gene	0.60
CBL	associated_with	gene	0.60
PDGFRB	associated_with	gene	0.60
MAPK14	therapeutic_target	gene	0.60
PI3K	associated_with	gene	0.60
HSP90AA1	therapeutic_target	gene	0.60
AKT1	therapeutic_target	gene	0.60
SRC	therapeutic_target	gene	0.60
HSPA8	therapeutic_target	gene	0.60
HSP70	expressed_in	gene	0.60
HSPA1L	expressed_in	gene	0.60
DNAJC10	expressed_in	gene	0.60
HSPH1	expressed_in	gene	0.60
SOD1	interacts_with	gene	0.60
CDC42	interacts_with	gene	0.60
YWHAZ	expressed_in	gene	0.60
CAV1	expressed_in	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

HSP90AB1

Understanding Entity Pages

Summary

Wiki Pages (21)

HSP90AB1 Gene

cbs-psp-daily-action-plan

Parkinson's Disease

Alzheimer's Disease

Prion vs Tau/Alpha-Synuclein Propagation: Mechanistic Comparison

Shared Proteinostasis Failure in Alzheimer's and Parkinson's Disease

Chaperone-Mediated Proteostasis Disease Comparison

Proteostasis Network in Neurodegeneration

DOCK1 Gene

Hsp70/Hsp90 Chaperone Pathway in Parkinson's Disease

AHSA2 Gene

Proteostasis and ERAD Pathway in Neurodegeneration

Protein Homeostasis in Neurodegeneration

NDUFS6 Gene

NDUFS5 — NADH:Ubiquinone Oxidoreductase Core Subunit S5

Expand Hsp90 content

Heat Shock Proteins

CRKL Gene

AHSA2 Protein — Activator of Hsp90 ATPase 2