DOCK1

Understanding Entity Pages

This page aggregates everything SciDEX knows about DOCK1: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

Summary

Comprehensive coverage of DOCK1 (Dedicator of Cytokinesis 1), a Rac-specific guanine nucleotide exchange factor implicated in neuronal development, synaptic plasticity, and neurodegenerative diseases including AD/PD.

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graph TD
    DOCK1["<b>DOCK1</b>"]
    Als{"Als"}
    DOCK1 -->|"regulates"| Als
    Ms{"Ms"}
    DOCK1 -->|"regulates"| Ms
    NDUFA12["NDUFA12"]
    DOCK1 -->|"associated with"| NDUFA12
    YWHAH["YWHAH"]
    DOCK1 -->|"associated with"| YWHAH
    NDUFS5["NDUFS5"]
    DOCK1 -->|"associated with"| NDUFS5
    neurodegeneration["neurodegeneration"]
    DOCK1 -->|"implicated in"| neurodegeneration
    NDUFA2["NDUFA2"]
    NDUFA2 -->|"associated with"| DOCK1
    NDUFS6["NDUFS6"]
    NDUFS6 -->|"associated with"| DOCK1
    NDUFA1["NDUFA1"]
    NDUFA1 -->|"associated with"| DOCK1
    CBL["CBL"]
    CBL -->|"associated with"| DOCK1
    PDGFRB["PDGFRB"]
    PDGFRB -->|"associated with"| DOCK1
    HSP90AB1["HSP90AB1"]
    HSP90AB1 -->|"associated with"| DOCK1
    CRKL["CRKL"]
    CRKL -->|"associated with"| DOCK1
    style DOCK1 fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0