concept

NF-κB SIGNALING PATHWAY

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about NF-κB SIGNALING PATHWAY: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

32Connections

0Hypotheses

1Analyses

17Outgoing

15Incoming

0Experiments

1Debates

No summary available yet.

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💡 Concept Info

Name	NF-κB SIGNALING PATHWAY

Pathway Diagram

graph TD
    NF__B_SIGNALING_PATHWAY["NF-kappaB SIGNALING PATHWAY"]
    NF__B_SIGNALING_PATHWAY -->|"upstream_of"| CCL2["CCL2"]
    NF__B_SIGNALING_PATHWAY -->|"mediates"| Pro_inflammatory_Mediators["Pro-inflammatory Mediators"]
    NF__B_SIGNALING_PATHWAY -->|"upstream_of"| TNF["TNF"]
    NF__B_SIGNALING_PATHWAY -->|"upstream_of"| IL_1_["IL-1beta"]
    NF__B_SIGNALING_PATHWAY -->|"upstream_of"| TNF__["TNF-alpha"]
    NF__B_SIGNALING_PATHWAY -->|"contributes to"| Neurodegeneration["Neurodegeneration"]
    NF__B_SIGNALING_PATHWAY -->|"mediates"| Neutrophilic_Inflammation["Neutrophilic Inflammation"]
    IL_34["IL-34"] -->|"activates"| NF__B_SIGNALING_PATHWAY
    Berberine["Berberine"] -->|"inhibits"| NF__B_SIGNALING_PATHWAY
    HV1["HV1"] -->|"modulates"| NF__B_SIGNALING_PATHWAY
    berberine["berberine"] -->|"inhibits"| NF__B_SIGNALING_PATHWAY
    I_B__degradation["IkappaBalpha degradation"] -->|"upstream_of"| NF__B_SIGNALING_PATHWAY
    TLR4["TLR4"] -->|"activates"| NF__B_SIGNALING_PATHWAY
    TRAF6["TRAF6"] -->|"activates"| NF__B_SIGNALING_PATHWAY

Outgoing (17)

Target	Relation	Type	Str
CCL2	upstream_of	protein	0.95
Pro-inflammatory Mediators	upregulates	compound	0.90
Cisplatin Resistance	associated_with	phenotype	0.90
Pro-inflammatory Mediators	mediates	compound	0.90
IL-1β	upstream_of	protein	0.85
TNF-α	upstream_of	protein	0.85
Neurodegeneration	contributes_to	disease	0.85
Neutrophilic Inflammation	mediates	process	0.85
TNF	upstream_of	protein	0.85
Autophagy	inhibits	process	0.85
SQSTM1	mediates	gene	0.85
Synaptic C1q deposition	regulates	phenotype	0.70
C1QA/C1QB/C1QC	regulates	gene	0.70
IL1B	regulates	gene	0.70
disease-associated microglia	associated_with	cell_type	0.70
Tnf-Α	regulates	protein	0.70
hippocampal inflammation	activates	process	0.70

Incoming (15)

Source	Relation	Type	Str
Danshensu	inhibits	drug	0.95
Berberine	inhibits	compound	0.95
IL-34	activates	protein	0.95
Sevoflurane	activates	drug	0.90
berberine	inhibits	drug	0.90
Tnf-Α	activates	protein	0.90
TRAF6	activates	protein	0.90
TNF-α	activates	protein	0.90
IκBα degradation	upstream_of	process	0.90
HV1	modulates	gene	0.90
HV1	regulates	gene	0.90
PIMREG	activates	protein	0.85
MCPIP1	inhibits	gene	0.85
Mahuang Fuzi Xixin Decoction	regulates	drug	0.70
Rb1	regulates	drug	0.70

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (1)

Scientific analyses that reference this entity

How does sevoflurane-induced NF-κB activation specifically trigger complement ca

neuroinflammation | 2026-04-08 | 5 hypotheses Top: 0.658

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (1)

Multi-agent debates referencing this entity

While the study demonstrates both NF-κB pathway activation and increased C1qa ex

closed · Rounds: 4 · Score: 0.74 · 2026-04-21

Related Research

Hypotheses and analyses mentioning NF-κB SIGNALING PATHWAY in their description or question text

No additional research found