gene

TRAF6

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about TRAF6: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

670Connections

0Hypotheses

1Analyses

50Outgoing

50Incoming

0Experiments

1Debates

Summary

TRAF6 is a gene implicated in neurodegeneration research. Key relationships include: activates, associated with, interacts with. Associated with Aging, Als, Atherosclerosis. Connected to 399 entities in the SciDEX knowledge graph.

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🧬 Gene Info

Gene Symbol	TRAF6
Chromosome	11p12
Protein Type	Gene
Function	TRAF6 is a central signaling molecule in multiple pathways
Molecular Weight	60 kDa
Amino Acids	524 aa
Pathways	NF-κB signaling, NF-κB, MAPK
GeneCards	TRAF6
Human Protein Atlas	TRAF6
Associated Diseases	Als, Atherosclerosis, Autoimmune, Cancer, Encephalitis, Inflammation
Known Drugs/Compounds	rapamycin
Interactions	ACVR1, AD, AKT, AKT1, AMPK, AND
KG Connections	670 knowledge graph edges
Databases	GeneCards UniProt NCBI Gene HPA STRING

Wiki Pages (3)

Knowledge base pages for this entity

Canonical Page

Pathway Diagram

flowchart TD
    TLR4["TLR4
Toll-like Receptor 4"]
    TLR2["TLR2
Toll-like Receptor 2"]
    MYD88["MYD88
Myeloid Differentiation
Primary Response 88"]
    TRAF6["TRAF6
TNF Receptor Associated
Factor 6"]
    NFKB1["NF-kappaB
Nuclear Factor
Kappa B"]
    STING1["STING1
Stimulator of
Interferon Genes"]
    
    NRF2["NRF2
Nuclear Factor
Erythroid 2"]
    MTOR["mTOR
Mechanistic Target
of Rapamycin"]
    BECLIN1["BECLIN1
Autophagy Regulator"]
    BCL2["BCL2
B-cell Lymphoma 2"]
    
    Neuroinflammation["Neuroinflammation
Glial Activation"]
    ALS["ALS
Amyotrophic Lateral
Sclerosis"]
    MS["Multiple Sclerosis
Demyelinating
Disease"]
    Neurodegeneration["Neurodegeneration
Neuronal Loss"]
    
    TLR4 -->|"activates"| TRAF6
    TLR2 -->|"activates"| TRAF6
    MYD88 -->|"mediates"| TRAF6
    STING1 -->|"interacts with"| TRAF6
    TRAF6 -->|"activates"| NFKB1
    TRAF6 -->|"promotes"| Neuroinflammation
    TRAF6 -->|"contributes to"| ALS
    TRAF6 -->|"promotes"| MS
    TRAF6 -->|"drives"| Neurodegeneration
    TRAF6 -->|"regulates"| NRF2
    TRAF6 -->|"modulates"| MTOR
    TRAF6 -->|"affects"| BECLIN1
    TRAF6 -->|"interacts with"| BCL2
    NFKB1 -->|"promotes"| Neuroinflammation
    Neuroinflammation -->|"leads to"| Neurodegeneration

    style TRAF6 fill:#006494
    style NRF2 fill:#1b5e20
    style BECLIN1 fill:#1b5e20
    style BCL2 fill:#1b5e20
    style TLR4 fill:#4a1a6b
    style TLR2 fill:#4a1a6b
    style MYD88 fill:#4a1a6b
    style STING1 fill:#4a1a6b
    style NFKB1 fill:#4a1a6b
    style MTOR fill:#4a1a6b
    style Neuroinflammation fill:#ef5350
    style ALS fill:#5d4400
    style MS fill:#5d4400
    style Neurodegeneration fill:#5d4400

Outgoing (333)

Target	Relation	Type	Str
NF-κB Signaling Pathway	activates	pathway	0.90
NF-κB signaling	upstream_of	pathway	0.90
UBIQUITIN	activates	gene	0.90
Autophagy	activates	pathway	0.80
Cancer	activates	disease	0.75
Als	activates	disease	0.75
Tumor	activates	disease	0.75
Als	interacts_with	disease	0.75
Tumor	interacts_with	disease	0.75
Als	regulates	disease	0.75
Inflammation	inhibits	disease	0.75
ULK1	activates	gene	0.70
Invasion	activates	pathway	0.70
Toll-Like Receptor	activates	pathway	0.70
CANCER	activates	gene	0.70
NFKB1	activates	protein	0.70
Schizophrenia	interacts_with	disease	0.65
Inflammation	activates	disease	0.65
Inflammation	interacts_with	disease	0.65
Ms	interacts_with	disease	0.65
Atherosclerosis	implicated_in	disease	0.65
Cancer	therapeutic_target	disease	0.65
Neuroinflammation	activates	disease	0.65
Ms	activates	disease	0.65
Neurodegeneration	regulates	disease	0.65
Neurodegeneration	activates	disease	0.65
Lung Cancer	therapeutic_target	disease	0.65
Senescence	interacts_with	disease	0.65
Autoimmune	associated_with	disease	0.65
Obesity	associated_with	disease	0.65
Als	expressed_in	disease	0.65
Aging	interacts_with	disease	0.65
Cancer	interacts_with	disease	0.65
Lung Cancer	activates	disease	0.65
Lymphoma	interacts_with	disease	0.65
Infection	activates	disease	0.65
Glioblastoma	inhibits	disease	0.65
ALS	activates	disease	0.65
Cancer	inhibits	disease	0.65
Tumor	associated_with	disease	0.65
Cancer	regulates	disease	0.65
Ms	inhibits	disease	0.65
Als	associated_with	disease	0.65
Psoriasis	regulates	disease	0.65
Inflammation	regulates	disease	0.65
Fibrosis	inhibits	disease	0.65
Inflammation	associated_with	disease	0.65
Ms	regulates	disease	0.65
Cancer	implicated_in	disease	0.65
Multiple Sclerosis	associated_with	disease	0.65

Incoming (337)

Source	Relation	Type	Str
TLR4	activates	protein	1.00
RARγ	interacts_with	protein	0.95
STING1	interacts_with	protein	0.80
TLR2	associated_with	protein	0.80
TNF	activates	gene	0.80
AUTOPHAGY	activates	gene	0.80
MICROGLIA	inhibits	cell_type	0.70
TFEB	interacts_with	gene	0.70
SOD1	interacts_with	gene	0.70
SIRT1	interacts_with	gene	0.70
PARK7	activates	gene	0.70
KEAP1	activates	gene	0.70
STING	activates	gene	0.70
SQSTM1	activates	gene	0.70
PINK1	activates	gene	0.70
GBA	activates	gene	0.70
APOE	activates	gene	0.70
GFAP	expressed_in	gene	0.70
ASTROCYTE	activates	cell_type	0.70
STAT3	expresses	gene	0.70
NRF2	expresses	gene	0.70
NECROPTOSIS	activates	pathway	0.70
MACROPHAGE	markers	cell_type	0.70
FOXO3	activates	gene	0.70
TLR4	expresses	gene	0.70
INFLAMMATION	activates	gene	0.70
NF-ΚB	activates	gene	0.70
miR-146a-5p	inhibits	gene	0.70
BECN1	activates	gene	0.70
TAB1	binds	protein	0.70
INFLAMMATION	inhibits	gene	0.70
CANCER	activates	gene	0.70
MITOPHAGY	activates	pathway	0.60
NOX	activates	gene	0.60
NF-KB	activates	gene	0.60
LC3B	interacts_with	gene	0.60
CANCER	regulates	gene	0.60
MIRNAS	regulates	gene	0.60
MIR-9-5P	inhibits	gene	0.60
IL-6	regulates	gene	0.60
CREB	activates	gene	0.60
P53	activates	gene	0.60
rapamycin	targets	drug	0.60
ERK	activates	gene	0.60
MAPK	activates	gene	0.60
ERK	regulates	gene	0.60
MAPK	regulates	gene	0.60
MYC	activates	gene	0.60
MAPK	co_discussed	gene	0.60
PYROPTOSIS	regulates	pathway	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (1)

Scientific analyses that reference this entity

What specific astrocyte-derived factors can 'erase' pathological microglial memo

neuroinflammation | 2026-04-08 | 5 hypotheses Top: 0.712

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (1)

Multi-agent debates referencing this entity

The astrocyte-mediated hypothesis proposes memory erasure but provides no molecu

closed · Rounds: 4 · Score: 0.65 · 2026-04-21

Related Research

Hypotheses and analyses mentioning TRAF6 in their description or question text

No additional research found