Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about TNF-Α: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
TNF-Α is a concept in neurodegeneration research. Key relationships include: activates, inhibits, therapeutic target. Associated with ALS, Aging, Als. Connected to 1360 entities in the SciDEX knowledge graph.
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| Name | TNF-Α |
| Key Genes/Proteins | ABCA1, ABCB1, ABCG1, ACETYL-COA, ACHE, ACSL4 |
| Related Diseases | A1 Astrocytes, A1 Reactive Astrocytes, Aging |
| Related Pathways | Adaptive Immunity |
graph TD
TNF__["TNF-Alpha"]
TNF__ -->|"target for"| Aging["Aging"]
TNF__ -->|"target for"| Ms["Ms"]
TNF__ -->|"inhibits"| Inflammation["Inflammation"]
TNF__ -->|"activates"| Dementia["Dementia"]
TNF__ -->|"activates"| Alzheimer["Alzheimer"]
TNF__ -->|"expressed in"| Als["Als"]
TNF__ -->|"activates"| Neuroinflammation["Neuroinflammation"]
EXERCISE["EXERCISE"] -->|"inhibits"| TNF__
IL6["IL6"] -->|"target for"| TNF__
MMP9["MMP9"] -->|"target for"| TNF__
PI3K["PI3K"] -->|"inhibits"| TNF__
PTGS2["PTGS2"] -->|"target for"| TNF__
AKT["AKT"] -->|"inhibits"| TNF__
TNF["TNF"] -->|"inhibits"| TNF__
EGFR["EGFR"] -->|"inhibits"| TNF__| Target | Relation | Type | Str |
|---|---|---|---|
| TNF-Α | encodes | protein | 0.00 |
| Als | regulates | disease | 1.00 |
| Cancer | activates | disease | 1.00 |
| Tumor | activates | disease | 1.00 |
| Depression | activates | disease | 1.00 |
| IFN | activates | gene | 1.00 |
| Als | activates | disease | 1.00 |
| AKT | activates | gene | 1.00 |
| Nf-Κb | activates | pathway | 1.00 |
| CANCER | activates | gene | 1.00 |
| Oxidative Stress | therapeutic_target | pathway | 1.00 |
| MTOR | activates | gene | 1.00 |
| MICROGLIA | activates | gene | 1.00 |
| Tumor | regulates | disease | 1.00 |
| Inflammation | treats | disease | 1.00 |
| Tumor | associated_with | disease | 1.00 |
| Aging | activates | disease | 1.00 |
| Autophagy | inhibits | pathway | 1.00 |
| ASTROCYTES | activates | gene | 1.00 |
| Als | therapeutic_target | disease | 1.00 |
| Nf-Kb | activates | pathway | 1.00 |
| Tumor | inhibits | disease | 1.00 |
| Apoptosis | inhibits | pathway | 1.00 |
| Mtor | inhibits | pathway | 1.00 |
| Als | inhibits | disease | 1.00 |
| BCL-2 | activates | gene | 1.00 |
| Nf-Κb | inhibits | pathway | 1.00 |
| Neuroinflammation | inhibits | disease | 1.00 |
| Neuroinflammation | activates | disease | 1.00 |
| Inflammation | regulates | disease | 1.00 |
| TNF | activates | gene | 1.00 |
| Inflammation | activates | disease | 1.00 |
| Inflammation | associated_with | disease | 1.00 |
| Pi3K/Akt | inhibits | pathway | 1.00 |
| Mtor | activates | pathway | 1.00 |
| Mapk | activates | pathway | 1.00 |
| Differentiation | activates | pathway | 1.00 |
| Toll-Like Receptor | inhibits | pathway | 1.00 |
| Parkinson | activates | disease | 1.00 |
| ASTROCYTE | activates | gene | 1.00 |
| Mapk | inhibits | pathway | 1.00 |
| AKT | inhibits | gene | 1.00 |
| Inflammation | therapeutic_target | disease | 1.00 |
| Oxidative Stress | inhibits | pathway | 1.00 |
| Pi3K/Akt | activates | pathway | 1.00 |
| Stroke | inhibits | disease | 1.00 |
| Stroke | activates | disease | 1.00 |
| Inflammation | inhibits | disease | 1.00 |
| NEUROINFLAMMATION | activates | gene | 1.00 |
| Oxidative Stress | activates | pathway | 1.00 |
| Source | Relation | Type | Str |
|---|---|---|---|
| TNF-Α | encodes | gene | 0.00 |
| IL-6 | expressed_in | gene | 1.00 |
| BAX | activates | gene | 1.00 |
| INFLAMMATION | activates | gene | 1.00 |
| PI3K | activates | gene | 1.00 |
| INFLAMMATION | associated_with | gene | 1.00 |
| TLR4 | activates | gene | 1.00 |
| TNF | expressed_in | gene | 1.00 |
| BDNF | activates | gene | 1.00 |
| NF-KB | activates | gene | 1.00 |
| IL-6 | regulates | gene | 1.00 |
| STAT3 | inhibits | gene | 1.00 |
| IL-6 | associated_with | gene | 1.00 |
| NF-ΚB | inhibits | gene | 1.00 |
| NF-ΚB | activates | gene | 1.00 |
| CYTOKINES | inhibits | gene | 1.00 |
| ROS | inhibits | gene | 1.00 |
| TNF | regulates | gene | 1.00 |
| INFLAMMATION | therapeutic_target | gene | 1.00 |
| CYTOKINES | regulates | gene | 1.00 |
| INFLAMMATION | inhibits | gene | 1.00 |
| TNF | inhibits | gene | 1.00 |
| NF-ΚB | regulates | gene | 1.00 |
| APOPTOSIS | inhibits | gene | 1.00 |
| PI3K | inhibits | gene | 1.00 |
| TLR4 | inhibits | gene | 1.00 |
| PARKINSON | activates | gene | 1.00 |
| IL-6 | inhibits | gene | 1.00 |
| OXIDATIVE STRESS | inhibits | gene | 1.00 |
| NEURODEGENERATION | activates | gene | 1.00 |
| APOPTOSIS | activates | gene | 1.00 |
| TNF | activates | gene | 1.00 |
| IL-6 | activates | gene | 1.00 |
| TNF | associated_with | gene | 1.00 |
| EXERCISE | inhibits | gene | 1.00 |
| INFLAMMATION | regulates | gene | 1.00 |
| CYTOKINES | activates | gene | 1.00 |
| OXIDATIVE STRESS | activates | gene | 1.00 |
| STAT3 | activates | gene | 1.00 |
| NLRP3 | inhibits | gene | 1.00 |
| NF-ΚB | therapeutic_target | gene | 1.00 |
| OXIDATIVE STRESS | therapeutic_target | gene | 1.00 |
| CYTOKINES | associated_with | gene | 1.00 |
| PARKINSON'S DISEASE | activates | gene | 1.00 |
| AMPK | activates | gene | 1.00 |
| HSYA | downregulates | compound | 0.95 |
| Musk | downregulates | drug | 0.95 |
| Danshensu | downregulates | drug | 0.95 |
| Berberine | inhibits | compound | 0.95 |
| anti-TNF-GRM ADC | binds_to | drug | 0.95 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| TNF-α/IL-1β-Cx43 Hemichannel Axis as Upstream Link Between S | 0.663 | cell-biology | What is the relative contribution of con |
| TNF-α/NF-κB Axis Upregulates P2RY12 in VSMCs | 0.650 | neurodegeneration | What determines P2RY12 receptor expressi |
| TNF-α–C1r/C1s Bridge Between NF-κB and Classical Complement | 0.600 | neuroinflammation | How does sevoflurane-induced NF-κB activ |
Scientific analyses that reference this entity
neurodegeneration | 2026-04-26 | 12 hypotheses Top: 0.878
immunomics | 2026-04-16 | 13 hypotheses Top: 0.565
neuroinflammation | 2026-04-13 | 0 hypotheses
pharmacology | 2026-04-11 | 0 hypotheses
neuroinflammation | 2026-04-08 | 5 hypotheses Top: 0.658
Experimental studies targeting or related to this entity
| Experiment | Type | Disease | Score | Feasibility | Model | Status | Est. Cost |
|---|---|---|---|---|---|---|---|
| Network pharmacology analysis of QTJD active compounds and pathways | exploratory | Mycoplasma pneumoniae pneumoni | 0.900 | 0.00 | computational network analysis | proposed | N/A |
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||
Multi-agent debates referencing this entity
closed · Rounds: 6 · Score: 0.95 · 2026-04-27
closed · Rounds: 4 · Score: 0.33 · 2026-04-27
closed · Rounds: 4 · Score: 0.44 · 2026-04-27
closed · Rounds: 4 · Score: 0.50 · 2026-04-26
closed · Rounds: 4 · Score: 0.50 · 2026-04-26
closed · Rounds: 4 · Score: 0.50 · 2026-04-26
closed · Rounds: 4 · Score: 0.50 · 2026-04-26
closed · Rounds: 6 · Score: 0.75 · 2026-04-26
closed · Rounds: 4 · Score: 0.81 · 2026-04-23
closed · Rounds: 4 · Score: 0.61 · 2026-04-21
Hypotheses and analyses mentioning TNF-Α in their description or question text
No additional research found