NR1D2

Understanding Entity Pages

This page aggregates everything SciDEX knows about NR1D2: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

Summary

NR1D2 (REV-ERBβ) is a nuclear receptor and transcriptional repressor that plays a critical role in circadian rhythm regulation and is implicated in neurodegenerative diseases.

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flowchart TD
    N0["NR1D2"]
    N1["Als"]
    N0 -->|"expressed in"| N1
    N2["CKAP4"]
    N0 -->|"associated with"| N2
    N3["GAIN"]
    N0 -->|"expressed in"| N3
    N4["LAMP3"]
    N0 -->|"expressed in"| N4
    N5["ABCG1"]
    N0 -->|"expressed in"| N5
    N6["WTAP"]
    N0 -->|"expressed in"| N6
    N7["RORA"]
    N0 -->|"associated with"| N7
    N8["TGM2"]
    N0 -->|"expressed in"| N8
    N9["PIK3R1"]
    N0 -->|"expressed in"| N9
    N10["neurodegeneration"]
    N0 -->|"implicated in"| N10

    classDef gene fill:#1a3a2a,stroke:#4caf50,color:#e0e0e0
    classDef protein fill:#1a2a3a,stroke:#4fc3f7,color:#e0e0e0
    classDef disease fill:#3a1a1a,stroke:#ef5350,color:#e0e0e0
    classDef pathway fill:#2a1a3a,stroke:#ce93d8,color:#e0e0e0
    classDef mechanism fill:#2a2a1a,stroke:#ffd54f,color:#e0e0e0
    class N1 disease
    class N2 gene
    class N3 gene
    class N4 gene
    class N5 gene
    class N6 gene
    class N7 gene
    class N8 gene
    class N9 gene