gene

PIK3R1

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about PIK3R1: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

382Connections

0Hypotheses

0Analyses

50Outgoing

50Incoming

Summary

PIK3R1 is a gene implicated in neurodegeneration research. Key relationships include: therapeutic target, regulates, associated with. Associated with Als, Alzheimer, Cancer. Connected to 168 entities in the SciDEX knowledge graph.

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🧬 Gene Info

Gene Symbol	PIK3R1
Full Name	Phosphoinositide-3-Kinase Regulatory Subunit 1
Aliases	p85α, PI3K-p85, GRB1
Chromosome	5q13.1
Function	is an important component in the neurobiology of neurodegenerative diseases.
Molecular Weight	85 kDa
Amino Acids	724 aa
Pathways	PI3K, mTOR, mtor, PI3K pathway
GeneCards	PIK3R1
Human Protein Atlas	PIK3R1
Protein Class	PI3K regulatory subunit (SH2 domain-containing)
PIK3CA (p110α)	Catalytic subunit
PTEN	Negative regulator
IRS1/2	Substrate
GRB2	Adapter protein
Associated Diseases	ALS, Aging, Alzheimer, Cancer, Fibrosis
Interactions	SRC, MTOR, IGF1, CDK1, QSOX1, LAMB2
KG Connections	382 knowledge graph edges
Databases	GeneCards UniProt NCBI Gene HPA STRING

Wiki Pages (20)

Knowledge base pages for this entity

Canonical Page

Pathway Diagram

graph TD
    PIK3R1["PIK3R1"]
    PIK3R1 -->|"regulates"| adipocyte_function["adipocyte function"]
    PIK3R1 -.biomarker for.-> Alzheimer["Alzheimer"]
    PIK3R1 -.biomarker for.-> Als["Als"]
    PIK3R1 -->|"target for"| Cancer["Cancer"]
    PIK3R1 -->|"target for"| Tumor["Tumor"]
    PIK3R1 -->|"activates"| Ms["Ms"]
    PIK3R1 -->|"regulates"| Glioblastoma["Glioblastoma"]
    IKBKB["IKBKB"] -.biomarker for.-> PIK3R1
    BNIP3["BNIP3"] -->|"regulates"| PIK3R1
    BCL2["BCL2"] -->|"regulates"| PIK3R1
    CTSL["CTSL"] -->|"regulates"| PIK3R1
    FOXO3["FOXO3"] -->|"target for"| PIK3R1
    BCL2_FAMILY["BCL2 FAMILY"] -->|"regulates"| PIK3R1
    CANCER["CANCER"] -->|"target for"| PIK3R1
    AUTOPHAGY["AUTOPHAGY"] -->|"regulates"| PIK3R1
    OXIDATIVE_STRESS["OXIDATIVE STRESS"] -->|"target for"| PIK3R1
    AUTOPHAGY_RELATED_GENES["AUTOPHAGY-RELATED GENES"] -->|"regulates"| PIK3R1

Outgoing (206)

Target	Relation	Type	Str
ds-83b31ef18d49	provides_data_for	dataset	1.00
adipocyte function	regulates	phenotype	0.80
Als	activates	disease	0.75
PI3K-AKT-mTOR signaling	participates_in	pathway	0.70
Alzheimer	biomarker_for	disease	0.65
Als	biomarker_for	disease	0.65
Als	therapeutic_target	disease	0.65
Cancer	therapeutic_target	disease	0.65
Tumor	therapeutic_target	disease	0.65
Ms	activates	disease	0.65
Cancer	activates	disease	0.65
Glioblastoma	regulates	disease	0.65
Ms	therapeutic_target	disease	0.65
Carcinoma	therapeutic_target	disease	0.65
Leukemia	therapeutic_target	disease	0.65
Fibrosis	causes	disease	0.65
Inflammation	causes	disease	0.65
Metabolic Syndrome	inhibits	disease	0.65
Inflammation	inhibits	disease	0.65
Cancer	implicated_in	disease	0.65
Als	implicated_in	disease	0.65
Melanoma	regulates	disease	0.65
Diabetes	regulates	disease	0.65
Colorectal Cancer	regulates	disease	0.65
Cancer	regulates	disease	0.65
Sepsis	activates	disease	0.65
Aging	activates	disease	0.65
Atherosclerosis	activates	disease	0.65
Inflammation	activates	disease	0.65
Neurodegeneration	therapeutic_target	disease	0.65
Alzheimer	therapeutic_target	disease	0.65
Als	causes	disease	0.65
Alzheimer	associated_with	disease	0.65
Als	associated_with	disease	0.65
Aging	associated_with	disease	0.65
ALS	causes	disease	0.65
ALS	associated_with	disease	0.65
Senescence	activates	disease	0.65
Als	inhibits	disease	0.65
Depression	activates	disease	0.65
Als	expressed_in	disease	0.65
ALS	expressed_in	disease	0.65
Alzheimer	regulates	disease	0.65
Neurodegeneration	expressed_in	disease	0.65
HDAC2	biomarker_for	gene	0.60
BECN1	regulates	gene	0.60
STAT3	regulates	gene	0.60
CTSB	regulates	gene	0.60
HIF1A	regulates	gene	0.60
FOXO1	therapeutic_target	gene	0.60

Incoming (176)

Source	Relation	Type	Str
ds-83b31ef18d49	data_in	dataset	1.00
PI3K	therapeutic_target	gene	0.70
AKT	therapeutic_target	gene	0.70
EGFR	therapeutic_target	gene	0.70
PIK3CA	therapeutic_target	gene	0.70
IKBKB	biomarker_for	gene	0.60
BNIP3	regulates	gene	0.60
BCL2	regulates	gene	0.60
CTSL	regulates	gene	0.60
FOXO3	therapeutic_target	gene	0.60
TP53	regulates	gene	0.60
NF1	regulates	gene	0.60
TP53	therapeutic_target	gene	0.60
SRC	therapeutic_target	gene	0.60
EGF	therapeutic_target	gene	0.60
HSP90AA1	therapeutic_target	gene	0.60
EP300	therapeutic_target	gene	0.60
BCL2L1	associated_with	gene	0.60
SRC	associated_with	gene	0.60
HIF1A	associated_with	gene	0.60
CDC42	associated_with	gene	0.60
STAT1	associated_with	gene	0.60
ESR1	associated_with	gene	0.60
IGF1R	associated_with	gene	0.60
AKT	associated_with	gene	0.60
AKT1	associated_with	gene	0.60
EGFR	associated_with	gene	0.60
RXRA	associated_with	gene	0.60
HSP90AA1	associated_with	gene	0.60
MAPK14	associated_with	gene	0.60
MDM2	associated_with	gene	0.60
RAF1	associated_with	gene	0.60
CREBBP	associated_with	gene	0.60
MTOR	therapeutic_target	gene	0.60
PIK3CD	therapeutic_target	gene	0.60
PIK3R3	therapeutic_target	gene	0.60
AKT3	therapeutic_target	gene	0.60
PIK3CB	therapeutic_target	gene	0.60
PIK3CA	associated_with	gene	0.60
IDH1	associated_with	gene	0.60
TP53	associated_with	gene	0.60
PI3K	associated_with	gene	0.60
DNMT3A	associated_with	gene	0.60
PTEN	associated_with	gene	0.60
PHF6	associated_with	gene	0.60
EP300	associated_with	gene	0.60
NOTCH1	therapeutic_target	gene	0.60
HRAS	therapeutic_target	gene	0.60
MAPK3	therapeutic_target	gene	0.60
MAPK1	therapeutic_target	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

PIK3R1

Understanding Entity Pages

Summary

Wiki Pages (20)

PIK3R1 Gene

SLC2A1 Gene

fip200

Thioflavin-T Fluorescence Assay for Protein Aggregation

PIK3R3 Gene

PI3K — Phosphoinositide 3-Kinase

PIK3R2 Gene

TRKB Gene

FGFR3 - Fibroblast Growth Factor Receptor 3

CTSL Gene

PIK3R1 Protein (p85α)

GRIK1 - Glutamate Receptor Kainate Type Subunit 1

PIK3CD Gene

RXRA

GRIK1 Gene

LAMP3 Protein

Lysosomal Associated Membrane Protein 3 (LAMP3)

PRKACB — Protein Kinase cAMP-Activated Catalytic Subunit Beta