RORA

Understanding Entity Pages

This page aggregates everything SciDEX knows about RORA: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

Summary

RORA (Retinoic Acid Receptor-Related Orphan Receptor Alpha) is a nuclear receptor that plays critical roles in circadian rhythm regulation, cerebellar development, and has been implicated in neurodegenerative diseases including Alzheimer's, Parkinson's, and ataxia.

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graph TD
    RORA["<b>RORA</b>"]
    Als{"Als"}
    RORA -->|"activates"| Als
    Hepatitis{"Hepatitis"}
    RORA -->|"associated with"| Hepatitis
    Glioblastoma{"Glioblastoma"}
    RORA -->|"associated with"| Glioblastoma
    Alzheimer{"Alzheimer"}
    RORA -->|"associated with"| Alzheimer
    Obesity{"Obesity"}
    RORA -->|"associated with"| Obesity
    Diabetes{"Diabetes"}
    RORA -->|"associated with"| Diabetes
    Stroke{"Stroke"}
    RORA -->|"associated with"| Stroke
    Multiple_Sclerosis{"Multiple Sclerosis"}
    RORA -->|"associated with"| Multiple_Sclerosis
    RORA -->|"associated with"| Als
    Cancer{"Cancer"}
    RORA -->|"associated with"| Cancer
    Carcinoma{"Carcinoma"}
    RORA -->|"associated with"| Carcinoma
    Fibrosis{"Fibrosis"}
    RORA -->|"associated with"| Fibrosis
    BECN1["BECN1"]
    BECN1 -->|"activates"| RORA
    style RORA fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0