gene

CKAP4

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about CKAP4: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

49Connections

0Hypotheses

0Analyses

37Outgoing

12Incoming

Summary

Gene page for CKAP4 encoding a microtubule-binding protein implicated in ALS and ER function

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🧬 Gene Info

Gene Symbol	CKAP4
Full Name	Cytoskeleton-Associated Protein 4
Chromosome	12p13.1
Function	is a type II transmembrane protein localized to the endoplasmic reticulum (ER), ER-Golgi intermediate compartment (ERGIC), and nuclear envelope.
Primary Expression	the brain, particularly in motor neurons of the spinal cord and motor cortex
Subcellular Localization	the endoplasmic reticulum (ER), ER-Golgi intermediate compartment (ERGIC), and nuclear envelope. The protein plays criti
Molecular Weight	63 kDa
Amino Acids	400 aa
Pathways	Wnt signaling
UniProt ID	Q07011
NCBI Gene ID	10527
Ensembl ID	ENSG00000129195
OMIM	616404
GeneCards	CKAP4
Human Protein Atlas	CKAP4
Associated Diseases	Alzheimer's Disease, Cancer
Interactions	RANBP2, NBR1, AKT, Rb, ADAM15, MMP9
KG Connections	49 knowledge graph edges
Databases	GeneCards HPA STRING

🔮 Predicted Structure: CKAP4 — AlphaFold Q07011 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (4)

Knowledge base pages for this entity

Canonical Page

Pathway Diagram

graph TD
    CKAP4["<b>CKAP4</b>"]
    Carcinoma{"Carcinoma"}
    CKAP4 -->|"activates"| Carcinoma
    Cancer{"Cancer"}
    CKAP4 -->|"activates"| Cancer
    Tumor{"Tumor"}
    CKAP4 -->|"activates"| Tumor
    Ms{"Ms"}
    CKAP4 -->|"activates"| Ms
    CKAP4 -->|"regulates"| Cancer
    CKAP4 -->|"regulates"| Carcinoma
    RANBP2["RANBP2"]
    CKAP4 -->|"activates"| RANBP2
    AUTOPHAGY["AUTOPHAGY"]
    CKAP4 -->|"activates"| AUTOPHAGY
    NBR1["NBR1"]
    CKAP4 -->|"activates"| NBR1
    Autophagy(["Autophagy"])
    CKAP4 -->|"activates"| Autophagy
    Glycolysis(["Glycolysis"])
    CKAP4 -->|"activates"| Glycolysis
    CANCER["CANCER"]
    CKAP4 -->|"regulates"| CANCER
    style CKAP4 fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0

Outgoing (37)

Target	Relation	Type	Str
Carcinoma	activates	disease	0.65
Cancer	activates	disease	0.65
Tumor	activates	disease	0.65
Ms	activates	disease	0.65
Cancer	regulates	disease	0.65
Carcinoma	regulates	disease	0.65
Hepatocellular Carcinoma	regulates	disease	0.65
Infection	activates	disease	0.65
Als	expressed_in	disease	0.65
RANBP2	activates	gene	0.60
NBR1	activates	gene	0.60
AKT	activates	gene	0.60
FAM134B	regulates	gene	0.60
Rb	activates	protein	0.60
ADAM15	activates	gene	0.60
MMP9	activates	gene	0.60
PI3K	inhibits	gene	0.60
GAIN	expressed_in	gene	0.60
LAMP3	expressed_in	gene	0.60
ABCG1	expressed_in	gene	0.60
RORA	associated_with	gene	0.60
TGM2	expressed_in	gene	0.60
PIK3R1	associated_with	gene	0.60
AUTOPHAGY	activates	gene	0.60
Autophagy	activates	pathway	0.60
Glycolysis	activates	pathway	0.60
CANCER	regulates	gene	0.60
Er Stress	activates	pathway	0.60
Akt	activates	pathway	0.60
TRIM21	regulates	gene	0.60
RETREG1	regulates	gene	0.60
Ubiquitin	activates	protein	0.60
RNA	activates	gene	0.60
Nf-Κb	inhibits	pathway	0.60
Pi3K/Akt	inhibits	pathway	0.60
Akt	inhibits	protein	0.60
WTAP	expressed_in	gene	0.60

Incoming (12)

Source	Relation	Type	Str
RANBP2	activates	gene	0.60
NBR1	activates	gene	0.60
FAM134B	regulates	gene	0.60
AKT	activates	gene	0.60
NR1D2	associated_with	gene	0.60
HIF-1Α	activates	gene	0.60
AND	interacts_with	gene	0.60
HIF	activates	gene	0.60
AND	regulates	gene	0.60
TRIM21	regulates	gene	0.60
RETREG1	regulates	gene	0.60
CANCER	regulates	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found