gene

NUP98

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about NUP98: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

27Connections
0Hypotheses
0Analyses
18Outgoing
9Incoming

Summary

Page for NUP98 — Nucleoporin 98

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🧬 Gene Info
Gene SymbolNUP98
Full NameNucleoporin 98
Chromosome11p15.4
Functionperipheral localization: NUP98 contributes to both the central channel barrier and cytoplasmic filament-associated gating
Primary Expressionneurons throughout the central nervous system, with enrichment in the hippocampus, [prefrontal cort
Molecular Weight40 kDa
Amino Acids1817 aa
Pathwaysubiquitin-proteasome
UniProt IDP52948
NCBI Gene ID4928
Ensembl IDENSG00000110713
OMIM601021
GeneCardsNUP98
Human Protein AtlasNUP98
Associated DiseasesAlzheimer's Disease, Huntington's Disease
Known Drugs/Compounds(S)-ACE-OH
InteractionsUBIQUITIN, ACE, NEURODEGENERATION, AND, TRIM21, Proteins
KG Connections27 knowledge graph edges
DatabasesGeneCardsHPASTRING
🔮 Predicted Structure: NUP98 — AlphaFold P52948 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (20)

Knowledge base pages for this entity

Canonical Page

NUP98 — Nucleoporin 98

gene · 1381 words

Nucleocytoplasmic Transport in Neurodegeneration

mechanism · 3182 words

C9orf72→RNA/Dipeptide Repeat Pathology→ALS/FTD — Causal Chain

mechanism · 3056 words

Nucleocytoplasmic Transport Defects in Neurodegenerative Diseases

mechanism · 2930 words

nucleocytoplasmic-transport-4r-tauopathies

mechanism · 2372 words

C9orf72 Hexanucleotide Repeat Expansion Pathway in ALS and FTD

mechanism · 2088 words

Pathway Diagram

flowchart TD
    N0["NUP98"]
    N1["TRIM21"]
    N1 -->|"interacts with"| N0
    N2["Cancer"]
    N0 -->|"activates"| N2
    N3["Neurodegeneration"]
    N0 -->|"activates"| N3
    N0 -->|"degrades"| N3
    N0 -->|"degrades"| N2
    N4["UBIQUITIN"]
    N0 -->|"activates"| N4
    N5["NEURODEGENERATION"]
    N0 -->|"activates"| N5
    N6["AND"]
    N0 -->|"activates"| N6
    N0 -->|"activates"| N1
    N7["ACE"]
    N0 -->|"activates"| N7
    N8["CANCER"]
    N0 -->|"degrades"| N8
    N0 -->|"degrades"| N5
    N9["Raf"]
    N0 -->|"activates"| N9
    N10["Ras"]
    N0 -->|"degrades"| N10

    classDef gene fill:#1a3a2a,stroke:#4caf50,color:#e0e0e0
    classDef protein fill:#1a2a3a,stroke:#4fc3f7,color:#e0e0e0
    classDef disease fill:#3a1a1a,stroke:#ef5350,color:#e0e0e0
    classDef pathway fill:#2a1a3a,stroke:#ce93d8,color:#e0e0e0
    classDef mechanism fill:#2a2a1a,stroke:#ffd54f,color:#e0e0e0
    class N2 disease
    class N3 disease
    class N4 gene
    class N5 gene
    class N6 gene
    class N7 gene
    class N8 gene
    class N9 protein
    class N10 protein

Outgoing (18)

TargetRelationTypeStr
Canceractivatesdisease0.65
Neurodegenerationactivatesdisease0.65
Neurodegenerationdegradesdisease0.65
Cancerdegradesdisease0.65
UBIQUITINactivatesgene0.60

Incoming (9)

SourceRelationTypeStr
(S)-ACE-OHinteracts_withcompound0.90
TRIM21degradesprotein0.90
ACEactivatesgene0.60
KMT2Aregulatesgene0.60
CANCERactivatesgene0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

HypothesisScoreDiseaseAnalysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMIDAuthorsJournalYearCitations
No papers found