Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about NUP98: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
| Gene Symbol | NUP98 |
| Full Name | Nucleoporin 98 |
| Chromosome | 11p15.4 |
| Function | peripheral localization: NUP98 contributes to both the central channel barrier and cytoplasmic filament-associated gating |
| Primary Expression | neurons throughout the central nervous system, with enrichment in the hippocampus, [prefrontal cort |
| Molecular Weight | 40 kDa |
| Amino Acids | 1817 aa |
| Pathways | ubiquitin-proteasome |
| UniProt ID | P52948 |
| NCBI Gene ID | 4928 |
| Ensembl ID | ENSG00000110713 |
| OMIM | 601021 |
| GeneCards | NUP98 |
| Human Protein Atlas | NUP98 |
| Associated Diseases | Alzheimer's Disease, Huntington's Disease |
| Known Drugs/Compounds | (S)-ACE-OH |
| Interactions | UBIQUITIN, ACE, NEURODEGENERATION, AND, TRIM21, Proteins |
| KG Connections | 27 knowledge graph edges |
| Databases | GeneCardsHPASTRING |
Knowledge base pages for this entity
flowchart TD
N0["NUP98"]
N1["TRIM21"]
N1 -->|"interacts with"| N0
N2["Cancer"]
N0 -->|"activates"| N2
N3["Neurodegeneration"]
N0 -->|"activates"| N3
N0 -->|"degrades"| N3
N0 -->|"degrades"| N2
N4["UBIQUITIN"]
N0 -->|"activates"| N4
N5["NEURODEGENERATION"]
N0 -->|"activates"| N5
N6["AND"]
N0 -->|"activates"| N6
N0 -->|"activates"| N1
N7["ACE"]
N0 -->|"activates"| N7
N8["CANCER"]
N0 -->|"degrades"| N8
N0 -->|"degrades"| N5
N9["Raf"]
N0 -->|"activates"| N9
N10["Ras"]
N0 -->|"degrades"| N10
classDef gene fill:#1a3a2a,stroke:#4caf50,color:#e0e0e0
classDef protein fill:#1a2a3a,stroke:#4fc3f7,color:#e0e0e0
classDef disease fill:#3a1a1a,stroke:#ef5350,color:#e0e0e0
classDef pathway fill:#2a1a3a,stroke:#ce93d8,color:#e0e0e0
classDef mechanism fill:#2a2a1a,stroke:#ffd54f,color:#e0e0e0
class N2 disease
class N3 disease
class N4 gene
class N5 gene
class N6 gene
class N7 gene
class N8 gene
class N9 protein
class N10 protein| Target | Relation | Type | Str |
|---|---|---|---|
| Cancer | activates | disease | 0.65 |
| Neurodegeneration | activates | disease | 0.65 |
| Neurodegeneration | degrades | disease | 0.65 |
| Cancer | degrades | disease | 0.65 |
| UBIQUITIN | activates | gene | 0.60 |
| ACE | activates | gene | 0.60 |
| PICALM | regulates | gene | 0.60 |
| NEURODEGENERATION | activates | gene | 0.60 |
| AND | activates | gene | 0.60 |
| TRIM21 | activates | gene | 0.60 |
| CANCER | degrades | gene | 0.60 |
| NEURODEGENERATION | degrades | gene | 0.60 |
| Raf | activates | protein | 0.60 |
| Ras | degrades | protein | 0.60 |
| App | degrades | protein | 0.60 |
| ubiquitin-proteasome | participates_in | pathway | 0.60 |
| epigenetic regulation | participates_in | pathway | 0.60 |
| Proteins | activates | protein | 0.50 |
| Source | Relation | Type | Str |
|---|---|---|---|
| (S)-ACE-OH | interacts_with | compound | 0.90 |
| TRIM21 | degrades | protein | 0.90 |
| ACE | activates | gene | 0.60 |
| KMT2A | regulates | gene | 0.60 |
| CANCER | activates | gene | 0.60 |
| NEURODEGENERATION | degrades | gene | 0.60 |
| TRIM21 | activates | gene | 0.60 |
| FLT3 | activates | gene | 0.60 |
| DNA | regulates | gene | 0.60 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| No targeting hypotheses | |||
Scientific analyses that reference this entity
No analyses mention this entity
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||