concept

PAI1

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about PAI1: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

19Connections
0Hypotheses
0Analyses
12Outgoing
7Incoming

No summary available yet. View on Wiki →

💡 Concept Info
NamePAI1
Key Genes/ProteinsBMAL1, PLASMIN, TNF, STAT1, NRAS, ASTROCYTES
Related DiseasesMs, Als
Related PathwaysSynaptic Plasticity, Complement, Immune Response

Wiki Pages (1)

Knowledge base pages for this entity

BMAL1 (ARNTL) Gene

gene · 641 words

Pathway Diagram

graph TD
    PAI1["PAI1"]
    PAI1 -->|"activates"| Ms["Ms"]
    PAI1 -->|"inhibits"| Als["Als"]
    PAI1 -->|"inhibits"| PLASMIN["PLASMIN"]
    PAI1 -->|"activates"| TNF["TNF"]
    PAI1 -->|"activates"| STAT1["STAT1"]
    PAI1 -->|"activates"| NRAS["NRAS"]
    PAI1 -->|"activates"| Synaptic_Plasticity["Synaptic Plasticity"]
    PAI1 -->|"activates"| Complement["Complement"]
    BMAL1["BMAL1"] -->|"activates"| PAI1
    C1Q["C1Q"] -->|"activates"| PAI1
    TNF -->|"activates"| PAI1
    NRAS -->|"activates"| PAI1
    GENES["GENES"] -->|"activates"| PAI1
    STAT1 -->|"activates"| PAI1
    COMPLEMENT["COMPLEMENT"] -->|"activates"| PAI1

Outgoing (12)

TargetRelationTypeStr
Msactivatesdisease0.65
Alsinhibitsdisease0.65
PLASMINinhibitsprotein0.64
TNFactivatesgene0.60
STAT1activatesgene0.60

Incoming (7)

SourceRelationTypeStr
BMAL1activatesgene0.72
C1Qactivatesgene0.60
TNFactivatesgene0.60
NRASactivatesgene0.60
GENESactivatesgene0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

HypothesisScoreDiseaseAnalysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMIDAuthorsJournalYearCitations
No papers found