Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about PAI1: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
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| Name | PAI1 |
| Key Genes/Proteins | BMAL1, PLASMIN, TNF, STAT1, NRAS, ASTROCYTES |
| Related Diseases | Ms, Als |
| Related Pathways | Synaptic Plasticity, Complement, Immune Response |
Knowledge base pages for this entity
graph TD
PAI1["PAI1"]
PAI1 -->|"activates"| Ms["Ms"]
PAI1 -->|"inhibits"| Als["Als"]
PAI1 -->|"inhibits"| PLASMIN["PLASMIN"]
PAI1 -->|"activates"| TNF["TNF"]
PAI1 -->|"activates"| STAT1["STAT1"]
PAI1 -->|"activates"| NRAS["NRAS"]
PAI1 -->|"activates"| Synaptic_Plasticity["Synaptic Plasticity"]
PAI1 -->|"activates"| Complement["Complement"]
BMAL1["BMAL1"] -->|"activates"| PAI1
C1Q["C1Q"] -->|"activates"| PAI1
TNF -->|"activates"| PAI1
NRAS -->|"activates"| PAI1
GENES["GENES"] -->|"activates"| PAI1
STAT1 -->|"activates"| PAI1
COMPLEMENT["COMPLEMENT"] -->|"activates"| PAI1| Target | Relation | Type | Str |
|---|---|---|---|
| Ms | activates | disease | 0.65 |
| Als | inhibits | disease | 0.65 |
| PLASMIN | inhibits | protein | 0.64 |
| TNF | activates | gene | 0.60 |
| STAT1 | activates | gene | 0.60 |
| NRAS | activates | gene | 0.60 |
| Synaptic Plasticity | activates | pathway | 0.60 |
| Complement | activates | pathway | 0.60 |
| Immune Response | activates | pathway | 0.60 |
| ASTROCYTES | activates | gene | 0.60 |
| C1Q | activates | gene | 0.60 |
| NEURODEGENERATIVE DISORDERS | activates | gene | 0.60 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| No targeting hypotheses | |||
Scientific analyses that reference this entity
No analyses mention this entity
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||