gene

NRAS

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about NRAS: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

172Connections
0Hypotheses
0Analyses
50Outgoing
50Incoming

Summary

NRAS is a gene implicated in neurodegeneration research. Key relationships include: activates, therapeutic target, associated with. Associated with Als, Cancer, Leukemia. Connected to 48 entities in the SciDEX knowledge graph.

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🧬 Gene Info
Gene SymbolNRAS
Full NameNRAS Proto-Oncogene, GTPase
Chromosome1p13.2
FunctionNRAS is a member of the Ras family of small GTPases that cycles between active GTP-bound and inactive GDP-bound states.
Primary Expressionthe brain with high expression in the hippocampus, cortex, and cerebellum
Molecular Weight21.2 kDa
Amino Acids189 aa
PathwaysMAPK, PI3K, MAPK signaling
UniProt IDP01111
Ensembl IDENSG00000213281
GeneCardsNRAS
Human Protein AtlasNRAS
BrainNeurons, astrocytes, and microglia
SkinMelanocytes and keratinocytes
Immune SystemT cells, B cells, and myeloid cells
Associated DiseasesALS, Cancer, Epilepsy, Ms, Tumor
InteractionsSTAT1, POT1, HRAS, RHEB, BRAF, FGFR2
KG Connections172 knowledge graph edges
DatabasesGeneCardsNCBI GeneHPASTRING
🔮 Predicted Structure: NRAS — AlphaFold P01111 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (17)

Knowledge base pages for this entity

Canonical Page

NRAS Gene

gene · 519 words

HRAS (Harvey Rat Sarcoma Viral Oncogene Homolog)

gene · 3426 words

RRAS2 — Related RAS Virus (R-Ras) Family Member 2

gene · 2759 words

RASA3 — Ras GTPase-Activating Protein 3

gene · 1805 words

RASA1 — RAS p120 GTPase Activating Protein

gene · 1487 words

RAF1 — RAF1 Proto-Oncogene, Serine/Threonine Kinase (c-Raf)

gene · 1374 words

Pathway Diagram

graph TD
    NRAS["<b>NRAS</b>"]
    Ms{"Ms"}
    NRAS -->|"activates"| Ms
    Als{"Als"}
    NRAS -->|"activates"| Als
    Cancer{"Cancer"}
    NRAS -->|"therapeutic target"| Cancer
    Leukemia{"Leukemia"}
    NRAS -->|"therapeutic target"| Leukemia
    Synaptic_Plasticity(["Synaptic Plasticity"])
    NRAS -->|"activates"| Synaptic_Plasticity
    Complement(["Complement"])
    NRAS -->|"activates"| Complement
    Immune_Response(["Immune Response"])
    NRAS -->|"activates"| Immune_Response
    GENES["GENES"]
    NRAS -->|"activates"| GENES
    STAT1["STAT1"]
    NRAS -->|"activates"| STAT1
    PAI1["PAI1"]
    NRAS -->|"activates"| PAI1
    NEURODEGENERATIVE_DISORDERS["NEURODEGENERATIVE DISORDERS"]
    NRAS -->|"activates"| NEURODEGENERATIVE_DISORDERS
    CANCER["CANCER"]
    NRAS -->|"therapeutic target"| CANCER
    C1Q["C1Q"]
    C1Q -->|"activates"| NRAS
    PAI1 -->|"activates"| NRAS
    TNF["TNF"]
    TNF -->|"activates"| NRAS
    STAT1 -->|"activates"| NRAS
    COMPLEMENT["COMPLEMENT"]
    COMPLEMENT -->|"activates"| NRAS
    ASTROCYTES["ASTROCYTES"]
    ASTROCYTES -->|"associated with"| NRAS
    NPM1["NPM1"]
    NPM1 -->|"associated with"| NRAS
    PER["PER"]
    PER -->|"therapeutic target"| NRAS
    TP53["TP53"]
    TP53 -->|"associated with"| NRAS
    TET2["TET2"]
    TET2 -->|"associated with"| NRAS
    DNMT3A["DNMT3A"]
    DNMT3A -->|"associated with"| NRAS
    style NRAS fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0

Outgoing (99)

TargetRelationTypeStr
cancerrisk_factor_fordisease0.95
SHOC2bindsprotein0.90
Cancerassociated_withdisease0.90
Tumorbiomarker_fordisease0.85
Alsactivatesdisease0.75

Incoming (73)

SourceRelationTypeStr
RASassociated_withprotein0.70
C1Qactivatesgene0.60
TNFactivatesgene0.60
STAT1activatesgene0.60
NPM1associated_withgene0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

HypothesisScoreDiseaseAnalysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMIDAuthorsJournalYearCitations
No papers found