gene

STAT1

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about STAT1: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

859Connections

1Hypotheses

2Analyses

50Outgoing

50Incoming

0Experiments

2Debates

Summary

Page for STAT1 Gene - Signal Transducer and Activator of Transcription 1

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🧬 Gene Info

Gene Symbol	STAT1
Full Name	Signal Transducer and Activator of Transcription 1
Aliases	Page for STAT1 Gene
Chromosome	2q32.2
Protein Type	Transcription Factor
Function	is an important component in the neurobiology of neurodegenerative diseases.
Molecular Weight	84 kDa
Pathways	cascade: ### Activation Mechanism, JAK-STAT signaling, JAK-STAT pathway
UniProt ID	P42224
NCBI Gene ID	6772
Ensembl ID	ENSG00000115415
GeneCards	STAT1
Human Protein Atlas	STAT1
Associated Diseases	Als, Autoimmune, Depression, Infection, Inflammation
Known Drugs/Compounds	berberine, Curcumin, metformin, valproic acid
Interactions	ACE, AGING, AKT1, alpha-synuclein, ALZHEIMER, ALZHEIMER'S DISEASE
KG Connections	858 knowledge graph edges
Databases	GeneCards HPA STRING

🔮 Predicted Structure: STAT1 — AlphaFold P42224 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (2)

Knowledge base pages for this entity

Canonical Page

STAT1 Gene - Signal Transducer and Activator of Transcription 1

gene · 1002 words

→

STAT1 Protein

protein · 965 words

→

Pathway Diagram

graph TD
    STAT1["STAT1"] -->|"Mediates"| INTERFERON_RESPONSE["INTERFERON_RESPONSE"]
    STAT1["STAT1"] -->|"Promotes"| ferroptosis["ferroptosis"]
    STAT1["STAT1"] -->|"Activates"| Cardiovascular["Cardiovascular"]
    STAT1["STAT1"] -->|"Activates"| Als["Als"]
    STAT1["STAT1"] -->|"Activates"| Hypertension["Hypertension"]
    STAT1["STAT1"] -->|"Activates"| Obesity["Obesity"]
    STAT1["STAT1"] -->|"Activates"| Ms["Ms"]
    STAT1["STAT1"] -->|"Activates"| Diabetes["Diabetes"]
    JAK2["JAK2"] -->|"Activates"| STAT1["STAT1"]
    JAK1["JAK1"] -->|"Activates"| STAT1["STAT1"]
    CSF2["CSF2"] -->|"Regulates"| STAT1["STAT1"]
    NAMPT["NAMPT"] -->|"Regulates"| STAT1["STAT1"]
    FGF2["FGF2"] -->|"Regulates"| STAT1["STAT1"]
    style STAT1 fill:#8d4900,color:#e0e0e0
    style INTERFERON_RESPONSE fill:#9C27B0,color:#e0e0e0
    style ferroptosis fill:#1b5e20,color:#e0e0e0
    style Cardiovascular fill:#b71c1c,color:#e0e0e0
    style Als fill:#b71c1c,color:#e0e0e0
    style Hypertension fill:#b71c1c,color:#e0e0e0
    style Obesity fill:#b71c1c,color:#e0e0e0
    style Ms fill:#b71c1c,color:#e0e0e0
    style Diabetes fill:#b71c1c,color:#e0e0e0
    style JAK2 fill:#0d47a1,color:#e0e0e0
    style JAK1 fill:#0d47a1,color:#e0e0e0
    style CSF2 fill:#8d4900,color:#e0e0e0
    style NAMPT fill:#8d4900,color:#e0e0e0
    style FGF2 fill:#8d4900,color:#e0e0e0

Outgoing (515)

Target	Relation	Type	Str
STAT1	encodes	protein	0.00
Inflammation	activates	disease	0.95
Interferon Response	involved_in	process	0.90
ULK1	associated_with	gene	0.90
Type I Interferon-Like Gene Signature	mediates	phenotype	0.90
Interferon-Stimulated Gene Response	involved_in	process	0.90
SARS-CoV-2 Infection	involved_in	disease	0.90
Interferon Response	component_of	pathway	0.90
Interferon-Stimulated Genes	component_of	pathway	0.85
Sepsis	activates	disease	0.85
Parkinson's disease	risk_factor_for	disease	0.85
ULK1	downregulates	protein	0.85
Microglial Autophagy	regulates	process	0.85
Als	inhibits	disease	0.85
Cancer	activates	disease	0.85
Lysine Acetylation	involved_in	mechanism	0.82
neural stem cells	inhibits	cell_type	0.80
neural stem cells	activates	cell_type	0.80
Nf-Κb	activates	pathway	0.80
CANCER	activates	gene	0.80
JAK1	activates	gene	0.80
INFLAMMATION	activates	gene	0.80
Inflammation	inhibits	disease	0.75
Als	therapeutic_target	disease	0.75
Als	regulates	disease	0.75
Als	activates	disease	0.75
Cancer	inhibits	disease	0.75
Carcinoma	activates	disease	0.75
Tumor	therapeutic_target	disease	0.75
Inflammation	therapeutic_target	disease	0.75
Cancer	therapeutic_target	disease	0.75
Fibrosis	inhibits	disease	0.75
Tumor	activates	disease	0.75
INTERFERON_RESPONSE	regulates	pathway	0.72
ubiquitin-proteasome	participates_in	pathway	0.70
INFLAMMATION	inhibits	gene	0.70
CXCL10	activates	gene	0.70
IFN	activates	gene	0.70
JAK-STAT signaling	participates_in	pathway	0.70
Tgf-Β	activates	pathway	0.70
MAPK signaling	participates_in	pathway	0.70
Mtor	activates	pathway	0.70
apoptosis pathway	participates_in	pathway	0.70
NF-kB signaling	participates_in	pathway	0.70
AKT	regulates	gene	0.70
Jak-Stat	inhibits	pathway	0.70
Metastasis	activates	pathway	0.70
TNF-Α	activates	gene	0.70
CANCER	inhibits	gene	0.70
PROINFLAMMATORY CYTOKINES	activates	gene	0.70

Incoming (344)

Source	Relation	Type	Str
STAT1	encodes	gene	0.00
Curcumin	inhibits	drug	0.90
Berberine	upregulates	compound	0.90
alpha-synuclein	activates	protein	0.90
TNF	activates	gene	0.90
JAK1	phosphorylates	protein	0.85
SNCA	interacts_with	protein	0.85
BAX	regulates	gene	0.80
NF-ΚB	activates	gene	0.80
CYTOKINES	activates	gene	0.80
CYTOKINES	inhibits	gene	0.70
AKT	therapeutic_target	gene	0.70
ERK	regulates	gene	0.70
APOPTOSIS	inhibits	gene	0.70
STAT3	inhibits	gene	0.70
METFORMIN	associated_with	drug	0.70
STAT3	activates	gene	0.70
NF-ΚB	inhibits	gene	0.70
CANCER	associated_with	disease	0.70
BAX	activates	gene	0.70
JAK2	activates	protein	0.70
IL6	activates	gene	0.70
TUMOR MICROENVIRONMENT	regulates	phenotype	0.65
JAK1	activates	protein	0.64
FGF8	regulates	gene	0.60
IRF1	activates	gene	0.60
HSPA1A	regulates	gene	0.60
P62	activates	gene	0.60
DDX58	activates	gene	0.60
CASP8	regulates	gene	0.60
NAMPT	regulates	gene	0.60
ATG3	regulates	gene	0.60
JAK1	inhibits	gene	0.60
HIF1A	activates	gene	0.60
CXCL10	activates	gene	0.60
S100A8	regulates	gene	0.60
CSF2RA	regulates	gene	0.60
CD4	therapeutic_target	gene	0.60
JAK2	therapeutic_target	gene	0.60
PTGS2	therapeutic_target	gene	0.60
TNF	therapeutic_target	gene	0.60
MDM2	therapeutic_target	gene	0.60
CD44	inhibits	gene	0.60
TLR4	inhibits	gene	0.60
NRAS	activates	gene	0.60
MTOR	activates	gene	0.60
ISG15	activates	gene	0.60
RELA	regulates	gene	0.60
BCL2L1	regulates	gene	0.60
JUN	regulates	gene	0.60

Targeting Hypotheses (1)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
TYRO3-STAT1 Axis to Preserve Parvalbumin Interneuron Functio	0.506	neuroinflammation	Why do TAM receptors protect against neu

Mentioning Analyses (2)

Scientific analyses that reference this entity

Why do TAM receptors protect against neuroinvasive viruses despite their known i

neuroinflammation | 2026-04-14 | 2 hypotheses Top: 0.513

What determines the specificity of TDP-43-induced mitochondrial DNA release for

neurodegeneration | 2026-04-07 | 7 hypotheses Top: 0.720

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (2)

Multi-agent debates referencing this entity

While the study establishes TDP-43 triggers mtDNA release via mPTP to activate c

closed · Rounds: 4 · Score: 0.73 · 2026-04-21

The finding that Mertk/Axl deficiency increases viral susceptibility contradicts

closed · Rounds: 4 · Score: 0.75 · 2026-04-15

Related Research

Hypotheses and analyses mentioning STAT1 in their description or question text

No additional research found