gene

STAT1

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about STAT1: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

882Connections

1Hypotheses

0Analyses

50Outgoing

50Incoming

Summary

Page for STAT1 Gene - Signal Transducer and Activator of Transcription 1

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🧬 Gene Info

Gene Symbol	STAT1
Full Name	Signal Transducer and Activator of Transcription 1
Aliases	Page for STAT1 Gene
Chromosome	2q32.2
Protein Type	Transcription Factor
Function	is an important component in the neurobiology of neurodegenerative diseases.
Molecular Weight	84 kDa
Pathways	cascade: ### Activation Mechanism, JAK-STAT signaling, JAK-STAT pathway
UniProt ID	P42224
NCBI Gene ID	6772
Ensembl ID	ENSG00000115415
GeneCards	STAT1
Human Protein Atlas	STAT1
Associated Diseases	ALS, Autoimmune, Depression, Infection, Inflammation
Known Drugs/Compounds	berberine, valproic acid, Curcumin, metformin
Interactions	STAT3, TLR4, EGFR, JAK1, NRAS, ISG15
KG Connections	882 knowledge graph edges
Databases	GeneCards HPA STRING

🔮 Predicted Structure: STAT1 — AlphaFold P42224 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (21)

Knowledge base pages for this entity

Canonical Page

Pathway Diagram

graph TD
    STAT1["STAT1"] -->|"Mediates"| INTERFERON_RESPONSE["INTERFERON_RESPONSE"]
    STAT1["STAT1"] -->|"Promotes"| ferroptosis["ferroptosis"]
    STAT1["STAT1"] -->|"Activates"| Cardiovascular["Cardiovascular"]
    STAT1["STAT1"] -->|"Activates"| Als["Als"]
    STAT1["STAT1"] -->|"Activates"| Hypertension["Hypertension"]
    STAT1["STAT1"] -->|"Activates"| Obesity["Obesity"]
    STAT1["STAT1"] -->|"Activates"| Ms["Ms"]
    STAT1["STAT1"] -->|"Activates"| Diabetes["Diabetes"]
    JAK2["JAK2"] -->|"Activates"| STAT1["STAT1"]
    JAK1["JAK1"] -->|"Activates"| STAT1["STAT1"]
    CSF2["CSF2"] -->|"Regulates"| STAT1["STAT1"]
    NAMPT["NAMPT"] -->|"Regulates"| STAT1["STAT1"]
    FGF2["FGF2"] -->|"Regulates"| STAT1["STAT1"]
    style STAT1 fill:#8d4900,color:#e0e0e0
    style INTERFERON_RESPONSE fill:#9C27B0,color:#e0e0e0
    style ferroptosis fill:#1b5e20,color:#e0e0e0
    style Cardiovascular fill:#b71c1c,color:#e0e0e0
    style Als fill:#b71c1c,color:#e0e0e0
    style Hypertension fill:#b71c1c,color:#e0e0e0
    style Obesity fill:#b71c1c,color:#e0e0e0
    style Ms fill:#b71c1c,color:#e0e0e0
    style Diabetes fill:#b71c1c,color:#e0e0e0
    style JAK2 fill:#0d47a1,color:#e0e0e0
    style JAK1 fill:#0d47a1,color:#e0e0e0
    style CSF2 fill:#8d4900,color:#e0e0e0
    style NAMPT fill:#8d4900,color:#e0e0e0
    style FGF2 fill:#8d4900,color:#e0e0e0

Outgoing (523)

Target	Relation	Type	Str
Inflammation	activates	disease	0.95
Interferon-Stimulated Gene Response	involved_in	process	0.90
Interferon Response	involved_in	process	0.90
ULK1	associated_with	gene	0.90
SARS-CoV-2 Infection	involved_in	disease	0.90
Interferon Response	component_of	pathway	0.90
Type I Interferon-Like Gene Signature	mediates	phenotype	0.90
ULK1	downregulates	protein	0.85
Microglial Autophagy	regulates	process	0.85
Interferon-Stimulated Genes	component_of	pathway	0.85
Cancer	activates	disease	0.85
Als	inhibits	disease	0.85
Sepsis	activates	disease	0.85
Parkinson's disease	risk_factor_for	disease	0.85
Lysine Acetylation	involved_in	mechanism	0.82
neural stem cells	activates	cell_type	0.80
neural stem cells	inhibits	cell_type	0.80
JAK1	activates	gene	0.80
Nf-Κb	activates	pathway	0.80
INFLAMMATION	activates	gene	0.80
CANCER	activates	gene	0.80
Als	activates	disease	0.75
Als	regulates	disease	0.75
Inflammation	inhibits	disease	0.75
Tumor	activates	disease	0.75
Carcinoma	activates	disease	0.75
Als	therapeutic_target	disease	0.75
Cancer	therapeutic_target	disease	0.75
Tumor	therapeutic_target	disease	0.75
Fibrosis	inhibits	disease	0.75
Inflammation	therapeutic_target	disease	0.75
Cancer	inhibits	disease	0.75
INTERFERON_RESPONSE	regulates	pathway	0.72
AKT	regulates	gene	0.70
MTOR	activates	gene	0.70
ferroptosis	activates	process	0.70
CXCL10	activates	gene	0.70
STING	activates	gene	0.70
DNA	activates	gene	0.70
Mtor	activates	pathway	0.70
Jak-Stat	inhibits	pathway	0.70
TNF-Α	activates	gene	0.70
Tgf-Β	activates	pathway	0.70
PROINFLAMMATORY CYTOKINES	activates	gene	0.70
IFN	activates	gene	0.70
INFLAMMATION	inhibits	gene	0.70
Apoptosis	inhibits	pathway	0.70
Nf-Κb	inhibits	pathway	0.70
GENES	inhibits	gene	0.70
JAK	inhibits	gene	0.70

Incoming (359)

Source	Relation	Type	Str
Berberine	upregulates	compound	0.90
Curcumin	inhibits	drug	0.90
alpha-synuclein	activates	protein	0.90
TNF	activates	gene	0.90
SNCA	interacts_with	protein	0.85
JAK1	phosphorylates	protein	0.85
BAX	regulates	gene	0.80
NF-ΚB	activates	gene	0.80
CYTOKINES	activates	gene	0.80
BAX	activates	gene	0.70
STAT3	activates	gene	0.70
JAK2	activates	protein	0.70
IL6	activates	gene	0.70
AKT	therapeutic_target	gene	0.70
STAT3	inhibits	gene	0.70
ERK	regulates	gene	0.70
CYTOKINES	inhibits	gene	0.70
APOPTOSIS	inhibits	gene	0.70
NF-ΚB	inhibits	gene	0.70
CANCER	destabilizes	disease	0.70
METFORMIN	destabilizes	drug	0.70
TUMOR MICROENVIRONMENT	regulates	phenotype	0.65
JAK1	activates	protein	0.64
CSF2	regulates	gene	0.60
NAMPT	regulates	gene	0.60
FGF2	regulates	gene	0.60
CXCL10	activates	gene	0.60
HSPA1A	regulates	gene	0.60
FGF8	regulates	gene	0.60
TLR4	regulates	gene	0.60
ISG15	activates	gene	0.60
HIF1A	activates	gene	0.60
IL6	inhibits	gene	0.60
C1Q	activates	gene	0.60
SGK1	associated_with	gene	0.60
FKBP5	associated_with	gene	0.60
A2M	associated_with	gene	0.60
AQP4	associated_with	gene	0.60
TNF	associated_with	gene	0.60
P2RX7	associated_with	gene	0.60
ISG15	associated_with	gene	0.60
P38	regulates	gene	0.60
PI3K	regulates	gene	0.60
SQSTM1	activates	gene	0.60
ULK1	inhibits	gene	0.60
ATG3	regulates	gene	0.60
IRF1	activates	gene	0.60
JAK3	expressed_in	gene	0.60
GAIN	expressed_in	gene	0.60
CD8	associated_with	gene	0.60

Targeting Hypotheses (1)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
TYRO3-STAT1 Axis to Preserve Parvalbumin Interneuron Functio	0.499	neuroinflammation	Why do TAM receptors protect against neu

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

STAT1

Understanding Entity Pages

Summary

Wiki Pages (21)

STAT1 Gene - Signal Transducer and Activator of Transcription 1

Microglia CD8+ T Cell Recruitment -- Supplementary WW Content

nlrc5-protein

CNTF Signaling Pathway in Neurodegeneration

JAK-STAT Signaling Pathway in Neurodegeneration

IL28B (Interleukin 28B)

Neuroinflammation Microglia

PKR Pathway in Neurodegeneration

Microglia Activation Mechanism

CD200R1 Gene

Neuroinflammation in Alzheimer and Parkinson Disease

Interferon Signaling in Neurodegeneration

TAM Receptor Signaling

Caspase-3 Protein

IL27 — Interleukin 27

MAP3K6 Gene

cd36

JAK-STAT and Cytokine Signaling in 4R-Tauopathies

herc5