gene

PDK3

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about PDK3: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

24Connections

0Hypotheses

0Analyses

11Outgoing

13Incoming

Summary

Page for PDK3 - 3-Phosphoinositide-Dependent Protein Kinase-3

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🧬 Gene Info

Gene Symbol	PDK3
Full Name	3-Phosphoinositide-Dependent Protein Kinase 3
Aliases	Page for PDK3
Chromosome	Xp22.11
Protein Type	Kinase
Function	encodes a member of the phosphoinositide-dependent protein kinase (PDK) family.
Primary Expression	various tissues, with high expression in brain, and is implicated in neurodegenerative diseases and cancer
Molecular Weight	~39 kDa
Amino Acids	350 aa
Pathways	PI3K, mTOR Pathway, AMPK Pathway, MAPK Pathway
UniProt ID	O95819
NCBI Gene ID	5165
Ensembl ID	ENSG00000168268
OMIM	300341
GeneCards	PDK3
Human Protein Atlas	PDK3
Associated Diseases	neurodegeneration
Interactions	HK2, PDK1, MYC, CANCER, GENES, E2F1
KG Connections	24 knowledge graph edges
Databases	GeneCards HPA STRING

🔮 Predicted Structure: PDK3 — AlphaFold O95819 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (3)

Knowledge base pages for this entity

Canonical Page

Pathway Diagram

graph TD
    PDK3["PDK3 (Pyruvate Dehydrogenase Kinase 3)"]
    
    %% Upstream regulators
    MYC["MYC"]
    C_MYC["C-MYC"]
    E2F1["E2F1"]
    GLUT1["GLUT1"]
    ENO1["ENO1"]
    LDHA["LDHA"]
    
    %% Downstream targets
    HK2["HK2 (Hexokinase 2)"]
    PDK1["PDK1"]
    Glycolysis["Glycolysis Pathway"]
    Mitosis["Cell Division"]
    
    %% Disease outcomes
    ALS["ALS"]
    Cancer["Cancer"]
    Neurodegeneration["Neurodegeneration"]
    
    %% Regulatory connections
    RB1["RB1 Tumor Suppressor"]
    
    %% Pathway connections
    MYC -->|"transcriptionally activates"| PDK3
    C_MYC -->|"transcriptionally activates"| PDK3
    E2F1 -->|"transcriptionally activates"| PDK3
    GLUT1 -->|"metabolically regulates"| PDK3
    ENO1 -->|"glycolytic feedback"| PDK3
    LDHA -->|"lactate signaling"| PDK3
    
    PDK3 -->|"phosphorylates and inhibits"| HK2
    PDK3 -->|"coordinates with"| PDK1
    PDK3 -->|"enhances"| Glycolysis
    PDK3 -->|"promotes"| Mitosis
    
    PDK3 -->|"contributes to"| ALS
    PDK3 -->|"promotes"| Cancer
    PDK3 -->|"involved in"| Neurodegeneration
    
    RB1 -->|"tumor suppressor pathway"| PDK3
    
    %% Styling
    style PDK3 fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0
    style Glycolysis fill:#1b5e20,stroke:#4caf50,stroke-width:2px
    style MYC fill:#4a1a6b,stroke:#9c27b0,stroke-width:2px
    style C_MYC fill:#4a1a6b,stroke:#9c27b0,stroke-width:2px
    style E2F1 fill:#4a1a6b,stroke:#9c27b0,stroke-width:2px
    style RB1 fill:#4a1a6b,stroke:#9c27b0,stroke-width:2px
    style ALS fill:#7d4200,stroke:#ff9800,stroke-width:2px
    style Cancer fill:#ef5350,stroke:#f44336,stroke-width:2px
    style Neurodegeneration fill:#7d4200,stroke:#ff9800,stroke-width:2px

Outgoing (11)

Target	Relation	Type	Str
Colorectal Cancer	activates	disease	0.65
Cancer	activates	disease	0.65
Tumor	activates	disease	0.65
Als	activates	disease	0.65
HK2	activates	gene	0.60
PDK1	activates	gene	0.60
MYC	activates	gene	0.60
Mitosis	activates	pathway	0.60
CANCER	activates	gene	0.60
GENES	activates	gene	0.60
Glycolysis	activates	pathway	0.60

Incoming (13)

Source	Relation	Type	Str
E2F1	activates	gene	0.60
ENO1	activates	gene	0.60
MYC	activates	gene	0.60
RB1	associated_with	gene	0.60
NBEA	associated_with	gene	0.60
LDHA	activates	gene	0.60
AND	activates	gene	0.60
C-MYC	activates	gene	0.60
GLUT1	activates	gene	0.60
GENES	activates	gene	0.60
CANCER	activates	gene	0.60
AND	associated_with	gene	0.60
GENES	associated_with	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found