E2F1

Understanding Entity Pages

This page aggregates everything SciDEX knows about E2F1: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

Summary

E2F1 is a gene implicated in neurodegeneration research. Key relationships include: activates, regulates, therapeutic target. Associated with ALS, Als, Cancer. Connected to 75 entities in the SciDEX knowledge graph.

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graph TD
    E2F1["<b>E2F1</b>"]
    RAB37["RAB37"]
    E2F1 -->|"activates"| RAB37
    Ms{"Ms"}
    E2F1 -->|"activates"| Ms
    Als{"Als"}
    E2F1 -->|"regulates"| Als
    E2F1 -->|"activates"| Als
    E2F1 -->|"expressed in"| Als
    Tumor{"Tumor"}
    E2F1 -->|"expressed in"| Tumor
    Cancer{"Cancer"}
    E2F1 -->|"activates"| Cancer
    E2F1 -->|"activates"| Tumor
    E2F1 -->|"therapeutic target"| Cancer
    E2F1 -->|"therapeutic target"| Tumor
    E2F1 -->|"interacts with"| Tumor
    E2F1 -->|"regulates"| Ms
    E2F7["E2F7"]
    E2F7 -->|"activates"| E2F1
    E2F8["E2F8"]
    E2F8 -->|"activates"| E2F1
    NEURODEGENERATION["NEURODEGENERATION"]
    NEURODEGENERATION -->|"regulates"| E2F1
    ATM["ATM"]
    ATM -->|"activates"| E2F1
    APOPTOSIS["APOPTOSIS"]
    APOPTOSIS -->|"activates"| E2F1
    style E2F1 fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0