gene 513 words KG: PDK3 2026-03-21
kind:genesection:genesstate:published
Contents

PDK3 - 3-Phosphoinositide-Dependent Protein Kinase-3

🧬 Gene Info
Gene SymbolPDK3
Full Name3-Phosphoinositide-Dependent Protein Kinase 3
AliasesPage for PDK3
ChromosomeXp22.11
Protein TypeKinase
Functionencodes a member of the phosphoinositide-dependent protein kinase (PDK) family.
Primary Expressionvarious tissues, with high expression in brain, and is implicated in neurodegenerative diseases and cancer
Molecular Weight~39 kDa
Amino Acids350 aa
PathwaysPI3K, mTOR Pathway, AMPK Pathway, MAPK Pathway
UniProt IDO95819
NCBI Gene ID5165
Ensembl IDENSG00000168268
OMIM300341
GeneCardsPDK3
Human Protein AtlasPDK3
Associated Diseasesneurodegeneration
InteractionsHK2, PDK1, MYC, CANCER, GENES, E2F1
KG Connections24 knowledge graph edges
DatabasesGeneCardsHPASTRING

Knowledge Graph

Related Hypotheses (9)

APOE-Dependent Autophagy Restoration
Score: 0.61
AMPK hypersensitivity in astrocytes creates enhanced mitocho
Score: 0.57
Near-infrared light therapy stimulates COX4-dependent mitoch
Score: 0.51
Heat Shock Protein 70 Disaggregase Amplification
Score: 0.51
Metabolic Switch Targeting for A1→A2 Repolarization
Score: 0.48

Related Analyses (9)

TDP-43 phase separation therapeutics for ALS-FTD
neurodegeneration · archived
Astrocyte reactivity subtypes in neurodegeneration
neurodegeneration · archived
Synaptic pruning by microglia in early AD
neurodegeneration · archived
Mitochondrial transfer between astrocytes and neurons
neurodegeneration · archived
Tau propagation mechanisms and therapeutic interception poin
neurodegeneration · archived

Related Experiments (12)

Animal Model Comparison for Neurodegenerative Disease Therap
clinical · proposed · Score: 0.40
Endocannabinoid System Dysfunction Validation in Parkinson's
clinical · proposed · Score: 0.40
Glymphatic-Circadian Axis Enhancement Therapy for Parkinson'
clinical · proposed · Score: 0.40
Gut Microbiome-Derived Metabolites in Alpha-Synuclein Propag
clinical · proposed · Score: 0.40
Neural Oscillation Dysfunction Validation in Parkinson's Dis
clinical · proposed · Score: 0.40

See Also (11)

Glycolysis Metabolism in Neurodegeneration
mechanism · KG edge: activates
Packard Center for ALS Research
institution · KG edge: activates
RB1 — Retinoblastoma 1
gene · KG edge: associated_with
Transdiagnostic Proteomic Changes in Neurodegeneration
gene · KG edge: activates
NBEA — Neurobeachin
gene · KG edge: associated_with

Knowledge Graph (12 edges)

PDK3 activates HK2
PDK3 activates PDK1
PDK3 activates MYC
PDK3 activates Mitosis
PDK3 activates CANCER
PDK3 activates GENES
PDK3 activates Colorectal Cancer
PDK3 activates Cancer
PDK3 activates Tumor
PDK3 activates Als