gene

ENO1

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about ENO1: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

156Connections
0Hypotheses
0Analyses
50Outgoing
47Incoming

Summary

ENO1 is a gene implicated in neurodegeneration research. Key relationships include: regulates, associated with, activates. Associated with Aging, Als, Breast Cancer. Connected to 102 entities in the SciDEX knowledge graph.

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🧬 Gene Info
Gene SymbolENO1
Full NameEnolase 1 (Alpha-enolase)
Chromosome1p36.23
Functionencodes a 433-amino acid protein (approximately 47 kDa).
Subcellular Localizationthe cell surface
Molecular Weight47 kDa
Amino Acids433 aa
PathwaysApoptosis, Autophagy, Glycolysis, Immune Response, Inflammasome
UniProt IDP06733
NCBI Gene ID2023
Ensembl IDENSG00000169064
OMIM172430
GeneCardsENO1
Human Protein AtlasENO1
Associated DiseasesAging, Cancer, Carcinoma, Ms, Parkinson, Tumor
InteractionsHSPA1A, FLT1, HSPA8, GAPDH, PDK3, HK2
KG Connections156 knowledge graph edges
DatabasesGeneCardsHPASTRING
🔮 Predicted Structure: ENO1 — AlphaFold P06733 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (9)

Knowledge base pages for this entity

Canonical Page

ENO1 Gene

gene · 1055 words

AIFM1 Gene

gene · 3251 words

ENO2 Gene

gene · 2001 words

PSMB9

gene · 1108 words

FBP1 Gene

gene · 968 words

ENO1 Protein

protein · 777 words

Pathway Diagram

graph TD
    ENO1["<b>ENO1</b>"]
    glycolysis(["glycolysis"])
    ENO1 -->|"participates in"| glycolysis
    Aging{"Aging"}
    ENO1 -->|"associated with"| Aging
    Ms{"Ms"}
    ENO1 -->|"associated with"| Ms
    ENO1 -->|"biomarker for"| Ms
    Als{"Als"}
    ENO1 -->|"biomarker for"| Als
    Parkinson{"Parkinson"}
    ENO1 -->|"associated with"| Parkinson
    Cancer{"Cancer"}
    ENO1 -->|"associated with"| Cancer
    Tumor{"Tumor"}
    ENO1 -->|"associated with"| Tumor
    Carcinoma{"Carcinoma"}
    ENO1 -->|"associated with"| Carcinoma
    ENO1 -->|"regulates"| Ms
    DDX5["DDX5"]
    ENO1 -->|"associated with"| DDX5
    CD8["CD8"]
    ENO1 -->|"associated with"| CD8
    AGING["AGING"]
    AGING -->|"associated with"| ENO1
    PSMB9["PSMB9"]
    PSMB9 -->|"associated with"| ENO1
    style ENO1 fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0

Outgoing (109)

TargetRelationTypeStr
glycolysisparticipates_inpathway0.90
Glycolysisregulatespathway0.70
Agingassociated_withdisease0.65
Msassociated_withdisease0.65
Msbiomarker_fordisease0.65

Incoming (47)

SourceRelationTypeStr
PSMB9associated_withgene0.60
UBIQUITINtherapeutic_targetgene0.60
PGK1regulatesgene0.60
GAPDHregulatesgene0.60
TKTregulatesgene0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

HypothesisScoreDiseaseAnalysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMIDAuthorsJournalYearCitations
No papers found