PLEKHG5

Understanding Entity Pages

This page aggregates everything SciDEX knows about PLEKHG5: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

Summary

PLEKHG5 is a gene implicated in neurodegeneration research. Key relationships include: regulates, activates, associated with. Associated with Als, Ms, motoneuron_disease. Connected to 19 entities in the SciDEX knowledge graph.

View on Wiki →

graph TD
    PLEKHG5["<b>PLEKHG5</b>"]
    autophagy["autophagy"]
    PLEKHG5 -->|"regulates"| autophagy
    Rab26["Rab26"]
    PLEKHG5 -->|"activates"| Rab26
    NF_kB(["NF-kB"])
    PLEKHG5 -->|"activates"| NF_kB
    motoneuron_disease{"motoneuron_disease"}
    PLEKHG5 -->|"implicated in"| motoneuron_disease
    Rac1["Rac1"]
    PLEKHG5 -->|"activates"| Rac1
    AKT["AKT"]
    PLEKHG5 -->|"activates"| AKT
    HDAC2["HDAC2"]
    PLEKHG5 -->|"interacts with"| HDAC2
    cell_polarity["cell_polarity"]
    PLEKHG5 -->|"regulates"| cell_polarity
    cell_adhesion["cell_adhesion"]
    PLEKHG5 -->|"regulates"| cell_adhesion
    cell_migration["cell_migration"]
    PLEKHG5 -->|"regulates"| cell_migration
    podosome_organization["podosome_organization"]
    PLEKHG5 -->|"regulates"| podosome_organization
    Als{"Als"}
    PLEKHG5 -->|"associated with"| Als
    SOD1["SOD1"]
    SOD1 -->|"activates"| PLEKHG5
    ALS["ALS"]
    ALS -->|"associated with"| PLEKHG5
    AUTOPHAGY["AUTOPHAGY"]
    AUTOPHAGY -->|"regulates"| PLEKHG5
    style PLEKHG5 fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0