Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about PM: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
Knowledge base pages for this entity
| Target | Relation | Type | Str |
|---|---|---|---|
| Cardiovascular Disease | risk_factor_for | disease | 0.95 |
| Myocardial Ischemia-Reperfusion Injury | associated_with | disease | 0.85 |
| CVD | associated_with | disease | 0.72 |
| MIR_INJURY | activates | phenotype | 0.64 |
| Source | Relation | Type | Str |
|---|---|---|---|
| No incoming edges | |||
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| Interneuron SYNGAP1 Deficiency Disrupts Cortical Circuit Ass | 0.576 | neurodevelopment | How does SYNGAP1, a 'synaptic' protein, |
| PIKFYVE Inhibition Activates Aggregate Exocytosis via PI(3,5 | 0.559 | neurodegeneration | How does PIKFYVE inhibition activate unc |
| MFSD2A-Targeted Lysophosphatidylcholine-SPM Conjugates as CN | 0.552 | neuropharmacology | What determines blood-brain barrier pene |
| Blood-Brain Barrier SPM Shuttle System | 0.550 | neurodegeneration | Neuroinflammation resolution mechanisms |
| SIRT1-Mediated Epigenetic Restoration of MFSD2A Expression R | 0.498 | neuropharmacology | What determines blood-brain barrier pene |
| Acid-Degradable LNP-Mediated Prenatal CRISPR Intervention fo | 0.465 | neurodegeneration | CRISPR-based therapeutic approaches for |
| Mitochondrial SPM Synthesis Platform Engineering | 0.383 | neurodegeneration | Neuroinflammation resolution mechanisms |
Scientific analyses that reference this entity
neuroinflammation | 2026-04-15 | 1 hypotheses Top: 0.650
neurodegeneration | 2026-04-15 | 2 hypotheses Top: 0.609
neurodegeneration | 2026-04-15 | 2 hypotheses Top: 0.675
neurodegeneration | 2026-04-15 | 1 hypotheses Top: 0.527
neurodegeneration | 2026-04-15 | 2 hypotheses Top: 0.586
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| Allosteric properties of mammalian ALOX15 orthologs. [PMID:41654134] | Yang J, Borchert A, Kuhn H | J Biol Chem | 2026 | 1 |
| Genome-Scale Meta-analysis of Host Responses to Staphylococcus aureus Identifies [PMID:40447280] | Russell CD, Goeldner-Thompson S, Smith E | J Infect Dis | 2025 | 1 |
| SBFI26 induces triple-negative breast cancer cells ferroptosis via lipid peroxid [PMID:38516826] | He G, Zhang Y, Feng Y, Chen T, Liu M, Ze | J Cell Mol Med | 2024 | 1 |
| An AAV capsid reprogrammed to bind human transferrin receptor mediates brain-wid [PMID:38753766] | Huang Q, Chan KY, Wu J, Botticello-Romer | Science | 2024 | 1 |
| Targeting the transferrin receptor to transport antisense oligonucleotides acros [PMID:39141703] | Barker SJ, Thayer MB, Kim C, Tatarakis D | Sci Transl Med | 2024 | 1 |
| Mitochondrial DNA stress triggers autophagy-dependent ferroptotic death. [PMID:32186434] | Li C, Zhang Y, Liu J, Kang R, Klionsky D | Autophagy | 2021 | 1 |
| Blood-brain barrier transport using a high affinity, brain-selective VNAR antibo [PMID:33241587] | Stocki P, Szary J, Rasmussen CLM, Demydc | FASEB J | 2021 | 1 |
| 5-lipoxygenase pathway and its downstream cysteinyl leukotrienes as potential th [PMID:32222525] | Chen F, Ghosh A, Lin J, Zhang C, Pan Y, | Brain Behav Immun | 2020 | 1 |
| Transferrin receptor 1 in cancer: a new sight for cancer therapy. [PMID:30034931] | Shen Y, Li X, Dong D, Zhang B, Xue Y, Sh | American journal of cancer res | 2018 | 1 |
| Decoding cell death signals in liver inflammation. [PMID:23567086] | Brenner C, Galluzzi L, Kepp O, Kroemer G | J Hepatol | 2013 | 1 |
| Arachidonate lipoxygenase 5 metabolism axis promoting ferroptosis: a potential d [PMID:41942611] | Chen L, Sun X, Zhang H, Zhang X, Muhetar | Br J Cancer | 2026 | 0 |
| Cadmium exposure is associated with impaired ovarian function: Potential role of [PMID:41548307] | ["Li J", "Wang Y", "Huang Y", "Li N", "Z | Journal of hazardous materials | 2026 | 0 |
| A humanized transferrin receptor 1-transferrin model supports functional iron ho [PMID:41338456] | Yesiltepe M, Metkar S, Yin T, Chakrabort | The Journal of biological chem | 2026 | 0 |
| Early hypoxia-induced secretome remodeling reveals adaptive mechanisms and bioma [PMID:41699623] | Wu Q, Jiang Y, Peng L, Dang Y, You C, Li | Molecular brain | 2026 | 0 |
| MITF programs macrophage iron homeostasis to drive gut-liver inflammatory axis i [PMID:41832955] | Han D, Han L, Kang L, Liu J, Zhang N, Tu | Cell reports | 2026 | 0 |
| Intestinal mast cell-derived leukotrienes mediate the anaphylactic response to i [PMID:40773543] | Bachtel ND, Cullen JL, Liu M, Erickson S | Science (New York, N.Y.) | 2025 | 0 |
| Ferrostatin-1 alleviates experimental cerebral malaria by regulating immune cell [PMID:41422632] | Yao S, Zhou X, Liao T, Yao C, Sun M, Gou | International journal for para | 2025 | 0 |
| Dietary Iron Deficiency in Adult Mice Increases Brain Uptake of High-Affinity, A [PMID:41299828] | Kostrikov S, Johnsen KB, Burkhart A, Hel | Journal of neurochemistry | 2025 | 0 |
| A covalent peptide-based lysosome-targeting protein degradation platform for can [PMID:39910101] | Xiao Y, He Z, Li W, Chen D, Niu X, Yang | Nature communications | 2025 | 0 |
| Dapagliflozin attenuates LPS-induced myocardial injury by reducing ferroptosis. [PMID:38743190] | ["Hu K", "Jiang P", "Hu J", "Song B", "H | Journal of bioenergetics and b | 2024 | 0 |