Microglial SPM Receptor Priming Therapy
🧪 Overview
Chronic pre-treatment with low-dose SPM receptor agonists could prime microglial resolution machinery before neurodegeneration onset, creating a neuroprotective state. This would involve upregulating ALX/FPR2, GPR32, and other SPM receptors.
Debate provenance: derived from debate `sess_sda-2026-04-01-gap-014` on question: SPMs (resolvins, protectins, maresins) from omega-3s may promote inflammation resolution. Are resolution failures druggable?. Consensus signal: domain_expert, skeptic, synthesizer, theorist discussed the mechanism terms ALX/FPR2, FPR2, GPR18, GPR32, Microglial, Priming, Receptor, SPM. Novelty signal: skeptic-discussed-with-qualified-concession.
🧬 Mechanism
Auto-built from this analysis's top knowledge-graph edges.
graph TD
TFRC["TFRC"] -->|encodes| transferrin_receptor["transferrin_receptor"]
transferrin_receptor_1["transferrin_receptor"] -->|mediates| blood_brain_barrier_trans["blood_brain_barrier_transport"]
CMKLR1["CMKLR1"] -->|encodes| GPR32["GPR32"]
GPR32_2["GPR32"] -->|regulates| microglial_efferocytosis["microglial_efferocytosis"]
microglial_efferocytosis_3["microglial_efferocytosis"] -->|resolves| neuroinflammation["neuroinflammation"]
BCL2L1["BCL2L1"] -->|encodes| BCL_xL["BCL-xL"]
BCL_xL_4["BCL-xL"] -->|promotes| senescent_cell_survival["senescent_cell_survival"]
ALOX12["ALOX12"] -->|encodes| n12_lipoxygenase["12-lipoxygenase"]
n12_lipoxygenase_5["12-lipoxygenase"] -->|catalyzes| maresin_biosynthesis["maresin_biosynthesis"]
ALOX15["ALOX15"] -->|encodes| n15_lipoxygenase["15-lipoxygenase"]
n15_lipoxygenase_6["15-lipoxygenase"] -->|catalyzes| lipoxin_A4_synthesis["lipoxin_A4_synthesis"]
lipoxin_A4_synthesis_7["lipoxin_A4_synthesis"] -->|regulates| astrocyte_polarization["astrocyte_polarization"]
style TFRC fill:#ce93d8,stroke:#333,color:#000
style transferrin_receptor fill:#4fc3f7,stroke:#333,color:#000
style transferrin_receptor_1 fill:#4fc3f7,stroke:#333,color:#000
style blood_brain_barrier_trans fill:#81c784,stroke:#333,color:#000
style CMKLR1 fill:#ce93d8,stroke:#333,color:#000
style GPR32 fill:#4fc3f7,stroke:#333,color:#000
style GPR32_2 fill:#4fc3f7,stroke:#333,color:#000
style microglial_efferocytosis fill:#81c784,stroke:#333,color:#000
style microglial_efferocytosis_3 fill:#81c784,stroke:#333,color:#000
style neuroinflammation fill:#ef5350,stroke:#333,color:#000
style BCL2L1 fill:#ce93d8,stroke:#333,color:#000
style BCL_xL fill:#4fc3f7,stroke:#333,color:#000
style BCL_xL_4 fill:#4fc3f7,stroke:#333,color:#000
style senescent_cell_survival fill:#81c784,stroke:#333,color:#000
style ALOX12 fill:#ce93d8,stroke:#333,color:#000
style n12_lipoxygenase fill:#4fc3f7,stroke:#333,color:#000
style n12_lipoxygenase_5 fill:#4fc3f7,stroke:#333,color:#000
style maresin_biosynthesis fill:#81c784,stroke:#333,color:#000
style ALOX15 fill:#ce93d8,stroke:#333,color:#000
style n15_lipoxygenase fill:#4fc3f7,stroke:#333,color:#000
style n15_lipoxygenase_6 fill:#4fc3f7,stroke:#333,color:#000
style lipoxin_A4_synthesis fill:#81c784,stroke:#333,color:#000
style lipoxin_A4_synthesis_7 fill:#81c784,stroke:#333,color:#000
style astrocyte_polarization fill:#81c784,stroke:#333,color:#000⚖️ Evidence
No linked papers recorded for this hypothesis yet.
🏥 Translation
🧬 3D Protein Structure — FPR2
No curated PDB or AlphaFold mapping for FPR2 yet. Search RCSB →
💉 Clinical Trials
No clinical trials data linked to this hypothesis yet.
No curated ClinVar variants loaded for this hypothesis.
Run scripts/backfill_clinvar_variants.py to fetch P/LP/VUS variants.
No DepMap CRISPR Chronos data found for FPR2, GPR32, GPR18.
Run python3 scripts/backfill_hypothesis_depmap.py to populate.
🏆 Tournament
🏆 Arenas / Elo
📊 Market Indicators
💾 Resource Usage
▸Metadatasource: v1_phase_c_backfill · origin_type: debate_round_mining
| source | v1_phase_c_backfill |
| origin_type | debate_round_mining |
| _schema_version | 1 |