gene 1,091 words KG: DPM2 2026-03-31
kind:genesection:genesstate:published
Contents

DPM2 Gene (Dolichol-Phosphate Mannosyltransferase Subunit 2)

🧬 Gene Info
Gene SymbolDPM2
AliasesDolichol-Phosphate Mannosyltransferase Subunit 2
Chromosome9q34.11
Protein TypeSynthase
FunctionThe DPM2 gene encodes a regulatory subunit of the dolichol-phosphate mannose (DPM) synthase complex[@schenk2001].
Primary ExpressionPurkinje cells of cerebellum
Subcellular LocalizationDPM2 helps localize the complex to the endoplasmic reticulum membrane
Molecular Weight40 kDa
UniProt IDO95477
NCBI Gene ID8769
Ensembl IDENSG00000110693
GeneCardsDPM2
Human Protein AtlasDPM2
MutationEffect
c.62G>Ap.Trp21
Associated DiseasesAls, Ms
InteractionsDPM1
KG Connections14 knowledge graph edges
DatabasesGeneCardsHPASTRING

Knowledge Graph

Related Hypotheses (2)

CYP46A1 Overexpression Gene Therapy
Score: 0.63
Astrocytic Lipoxin A4 Pathway Restoration via ALOX15 Gene Th
Score: 0.45

Related Analyses (3)

Neuroinflammation resolution mechanisms and pro-resolving me
neurodegeneration · archived
Lipid raft composition changes in synaptic neurodegeneration
neurodegeneration · completed
Circuit-level neural dynamics in neurodegeneration
neuroscience · archived

Related Experiments (2)

ER-Golgi Secretory Pathway Dysfunction in PD - Experiment De
clinical · proposed · Score: 0.40
Macroautophagy Dysfunction in PD - Experiment Design
clinical · proposed · Score: 0.40

See Also (12)

Packard Center for ALS Research
institution · KG edge: associated_with
TBK1-Mediated Neuroinflammation Hypothesis — Autophagy
hypothesis · KG edge: associated_with
OPTN — Optineurin
gene · KG edge: associated_with
FERMT2 Gene
gene · KG edge: associated_with
DPM3 Gene (Dolichol-Phosphate Mannosyltransferase Subun
gene · KG edge: stabilizes

Knowledge Graph (12 edges)

DPM2 associated_with TBK1
DPM2 stabilizes DPM3
DPM2 associated_with Als
DPM2 associated_with Ms
ATXN2 associated_with DPM2
CACNA1A associated_with DPM2
CHAT associated_with DPM2
FERMT2 associated_with DPM2
OPTN associated_with DPM2
ABCA1 associated_with DPM2