gene 1,701 words KG: TPM1 2026-03-28
kind:genesection:genesstate:published
Contents

TPM1 — Tropomyosin 1

🧬 Gene Info
Gene SymbolTPM1
Full NameTropomyosin 1
Chromosome15q22.1
FunctionTropomyosins are key regulators of actin filament dynamics and function through several mechanisms
Primary Expressionneurons and has been implicated in neurodegenerative diseases, particularly [Amyotrophic Lateral Sclerosis (ALS](/diseases/amyotr
PathwaysAutophagy, Histone Modification
UniProt IDP09493
NCBI Gene ID7168
Ensembl IDENSG00000140416
OMIM191010
GeneCardsTPM1
Human Protein AtlasTPM1
Associated Diseasesneurodegeneration
InteractionsIDH3A, BNIP3, APOPTOSIS, BCL-2, MITOPHAGY, AND
KG Connections29 knowledge graph edges
DatabasesGeneCardsHPASTRING

Knowledge Graph

Related Hypotheses (1)

Reelin-Mediated Cytoskeletal Stabilization Protocol
Score: 0.45

Related Analyses (1)

Circuit-level neural dynamics in neurodegeneration
neuroscience · archived

Related Experiments (5)

Basic Mechanism: Membrane-Driven Alpha-Synuclein Nucleation
validation · proposed · Score: 0.40
Multiscale Computational Modeling of Protein Aggregation Kin
validation · proposed · Score: 0.40
Non-Motor Symptom Progression in Parkinson's Disease — Mecha
clinical · proposed · Score: 0.40
Mechanism: Progranulin Loss and TDP-43 Pathology in FTD
validation · proposed · Score: 0.40
TDP-43 PET Ligand Development for FTD and ALS
clinical · proposed · Score: 0.40

See Also (15)

Mitophagy Receptor Pathway in Neurodegeneration
mechanism · KG edge: inhibits
Apoptosis Pathway in Neurodegeneration
mechanism · KG edge: inhibits
Packard Center for ALS Research
institution · KG edge: inhibits
PLN Gene
gene · KG edge: therapeutic_target
LMNA Gene
gene · KG edge: therapeutic_target

Knowledge Graph (12 edges)

TPM1 inhibits IDH3A
TPM1 therapeutic_target LMNA
TPM1 therapeutic_target ATF4
TPM1 inhibits BNIP3
TPM1 inhibits APOPTOSIS
TPM1 regulates AUTOPHAGY
TPM1 inhibits BCL-2
TPM1 inhibits Fibrosis
TPM1 inhibits Als
TPM1 regulates Cardiac