Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about Phosphorylation: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
Knowledge base pages for this entity
| Target | Relation | Type | Str |
|---|---|---|---|
| G3BP1 | modulates | protein | 0.85 |
| Liquid-Liquid Phase Separation | regulates | process | 0.85 |
| Phase Separation | associated_with | process | 0.85 |
| SNCA | modulates | protein | 0.85 |
| Source | Relation | Type | Str |
|---|---|---|---|
| TAU | involved_in | protein | 0.98 |
| Tau | involved_in | protein | 0.90 |
| HSP27 | associated_with | protein | 0.85 |
| PGC1A | involved_in | gene | 0.85 |
| Α-SYNUCLEIN | involved_in | protein | 0.85 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| p38α Inhibitor and PRMT1 Activator Combination to Restore Ph | 0.615 | neurodegeneration | What is the therapeutic window between i |
| HSPB1 Phosphorylation Mimetics to Promote Protective TDP-43 | 0.598 | neurodegeneration | What is the therapeutic window between i |
| Astroglial Gap Junction Coordination via Connexin-43 Phospho | 0.497 | neurodegeneration | Perivascular spaces and glymphatic clear |
| Selective OGA Inhibition as 'Tau Stabilization' Strategy Wit | 0.433 | neurodegeneration | Which tau PTMs are both disease-specific |
Scientific analyses that reference this entity
neurodegeneration | 2026-04-04 | 0 hypotheses
neurodegeneration | 2026-04-04 | 0 hypotheses
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| PIEZO channels link mechanical forces to uterine contractions in parturition. [PMID:41231991] | Zhang Y, Kini SA, Mishkanian SA, Yarishk | Science | 2025 | 1 |
| GJA1-20k and Mitochondrial Dynamics. [PMID:35399255] | Shimura D, Shaw RM | Front Physiol | 2022 | 1 |
| Inhibition of connexin43 improves functional recovery after ischemic brain injur [PMID:25988944] | Li X, Zhao H, Tan X, Kostrzewa RM, Du G, | Glia | 2015 | 1 |
| Connexin43 Deficiency Leads to Ventricular Arrhythmias by Reprogramming Proline [PMID:41618855] | ["Ying H", "Fan H", "Wang Y", "Jiang R", | Advanced science (Weinheim, Ba | 2026 | 0 |
| Prenatal lipopolysaccharide exposure programs cardiac fibrosis via dysregulating [PMID:41789580] | Wen Y, Yuan Y, Zhang H, Liu Y | Molecular medicine reports | 2026 | 0 |
| Bladder under stress: Pathological and adaptive shifts in channel expression. [PMID:41945411] | Swärd K, Andersson KE, Uvelius B | Channels (Austin) | 2026 | 0 |
| The relationship between Connexin 43 (Cx43) and partner protein, human discs lar [PMID:41703342] | ["Scott H", "Dong L", "Stevenson A", "Ma | Cell and tissue research | 2026 | 0 |
| Thermal Adaptation Inhibits the Wnt Signaling Pathway Regulating Autophagy and I [PMID:41889212] | ["Song R", "Zhang Z", "Zhu S", "Fu K", " | Molecular reproduction and dev | 2026 | 0 |
| Identification and validation of ferroptosis-related genes for diabetic nephropa [PMID:41825713] | Duan H, Wang Y, Wang Q, Yan J, Fan X, Wu | European journal of pharmacolo | 2026 | 0 |
| Danggui Sini decoction attenuates intervertebral disc degeneration by regulating [PMID:41812505] | Chen S, Zhou X, Wang W, Zheng Y, Kang R, | International immunopharmacolo | 2026 | 0 |
| Reproductive tissue-derived stromal cells rescue fertility by coupling follicula [PMID:41888633] | ["Borutinskait\u0117 V", "Krastinait\u01 | Stem cells translational medic | 2026 | 0 |
| A Single-Cell Transcriptomic Atlas Elucidates a Microglial Gene Signature Linkin [PMID:41884157] | ["Zhong R", "Yang H", "Li X", "Wang F", | Journal of inflammation resear | 2026 | 0 |
| Essential Role of CD63 in Maintaining Corneal Epithelial Identity in the Human L [PMID:41817143] | ["Sasamoto Y", "Suzuki K", "Sato S", "Le | Investigative ophthalmology & | 2026 | 0 |
| Hypoxia Increases Connexin46 and Connexin43 Levels in KNS-42 Glioblastoma Cells. [PMID:41898710] | Minogue PJ, Beyer EC, Berthoud VM | International journal of molec | 2026 | 0 |
| Cx43 modulates malignant phenotypes in bladder cancer cells via the c-Src/PTEN/F [PMID:41910821] | ["Chi Q", "Xu H", "Li H", "Ma G", "Li X" | Journal of molecular histology | 2026 | 0 |
| SnRNA-seq reveals the ameliorative effects of optimized Xueyu Jingshen formula o [PMID:41720010] | Bai J, Xie N, Hou Y, Yan J, Chen M, Yu S | Phytomedicine : international | 2026 | 0 |
| Transcriptome and alternative splicing analyses uncover immune-centric pathogene [PMID:41911957] | ["Yan W", "Na L", "Tao G", "Jing L", "Yi | Gene | 2026 | 0 |
| Opposing roles of p38α-mediated phosphorylation and PRMT1-mediated arginine meth [PMID:39817908] | Aikio M, Odeh HM, Wobst HJ, Lee BL, Chan | Cell Rep | 2025 | 0 |
| Heat-shock chaperone HSPB1 mitigates poly-glycine-induced neurodegeneration via [PMID:39936620] | Ding N, Song Y, Zhang Y, Yu W, Li X et a | Autophagy | 2025 | 0 |
| Reactive astrocytes secrete the chaperone HSPB1 to mediate neuroprotection. [PMID:38507480] | Yang F, Beltran-Lobo P, Sung K, Goldrick | Sci Adv | 2024 | 0 |