HSP27

Understanding Entity Pages

This page aggregates everything SciDEX knows about HSP27: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

Summary

HSP27 is a protein involved in neurodegeneration research. Key relationships include: regulates, treats, therapeutic target. Associated with Als, Amyotrophic Lateral Sclerosis, Cancer. Connected to 83 entities in the SciDEX knowledge graph.

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graph TD
    HSP27["<b>HSP27</b>"]
    Neurodegeneration{"Neurodegeneration"}
    HSP27 -->|"regulates"| Neurodegeneration
    Als{"Als"}
    HSP27 -->|"regulates"| Als
    Amyotrophic_Lateral_Sclerosis{"Amyotrophic Lateral Sclerosis"}
    HSP27 -->|"regulates"| Amyotrophic_Lateral_Sclerosis
    Ms{"Ms"}
    HSP27 -->|"regulates"| Ms
    HSP27 -->|"activates"| Als
    HSP27 -->|"activates"| Ms
    HSP27 -->|"activates"| Amyotrophic_Lateral_Sclerosis
    Cancer{"Cancer"}
    HSP27 -->|"interacts with"| Cancer
    Tumor{"Tumor"}
    HSP27 -->|"regulates"| Tumor
    Parkinson{"Parkinson"}
    HSP27 -->|"therapeutic target"| Parkinson
    Fibrosis{"Fibrosis"}
    HSP27 -->|"regulates"| Fibrosis
    Autophagy(["Autophagy"])
    HSP27 -->|"regulates"| Autophagy
    P62["P62"]
    P62 -->|"regulates"| HSP27
    SQSTM1["SQSTM1"]
    SQSTM1 -->|"regulates"| HSP27
    CTSH["CTSH"]
    CTSH -->|"interacts with"| HSP27
    COMPLEMENT["COMPLEMENT"]
    COMPLEMENT -->|"interacts with"| HSP27
    C1QB["C1QB"]
    C1QB -->|"interacts with"| HSP27
    ASTROCYTES["ASTROCYTES"]
    ASTROCYTES -->|"activates"| HSP27
    SOD1["SOD1"]
    SOD1 -->|"activates"| HSP27
    IRS1["IRS1"]
    IRS1 -->|"interacts with"| HSP27
    CANCER["CANCER"]
    CANCER -->|"interacts with"| HSP27
    PARKINSON_S_DISEASE["PARKINSON'S DISEASE"]
    PARKINSON_S_DISEASE -->|"therapeutic target"| HSP27
    MITOPHAGY["MITOPHAGY"]
    MITOPHAGY -->|"therapeutic target"| HSP27
    HSP70["HSP70"]
    HSP70 -->|"therapeutic target"| HSP27
    style HSP27 fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0